Sina Vakili

Shiraz University of Medical Sciences

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Amir Savardashtaki

Shiraz University of Medical Sciences

Reza Tabrizi

Shahid Beheshti University of Medical Sciences

Mohammad Samare‐Najaf

High Institute for Education and Research in Transfusion Medicine

Morteza Jafarinia

Shiraz University of Medical Sciences

Bahia Namavar Jahromi

Shiraz University of Medical Sciences

Fatemeh Zal

Shiraz University of Medical Sciences

Kamran Bagheri Lankarani

Shiraz University of Medical Sciences

Hamed Akbari

Kerman University of Medical Sciences

Gholamreza Asadikaram

Kerman University of Medical Sciences

Ahmad Movahedpour

Yasuj University of Medical Sciences

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Shiraz University of Medical Sciences

147

Shiraz University

Tehran University of Medical Sciences

Kerman University of Medical Sciences

Neurological Surgery

Iran University of Medical Sciences

Mashhad University of Medical Sciences

Fasa University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Isfahan University of Medical Sciences

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Journal of Stroke and Cerebrovascular Diseases (2020)

Jared Cooper Anubhav G. Amin Michael G. Kim Alan Stein José Manuel García‐Domínguez

Table (database)

10.1016/s1052-3057(20)30698-4

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Citations (0)

Clinical Guidelines on the Use of Assisted Reproductive Technology During Covid-19 Pandemic: A Minireview of the Current Literature

DOAJ (DOAJ: Directory of Open Access Journals) (2022)

Soudabeh Sabetian Bahia Namavar Jahromi Farnia Feiz Isabella Castiglioni Claudia Cava

Pandemic

2019-20 coronavirus outbreak

10.30476/jhsss.2021.92214.1322

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Citations (1)

Quercetin potentiates the anti-osteoporotic effects of alendronate through modulation of autophagy and apoptosis mechanisms in ovariectomy-induced bone loss rat model

Molecular Biology Reports (2023)

Sima Mousavi Sina Vakili Fatemeh Zal Amir Savardashtaki Morteza Jafarinia

Osteocyte

Bone remodeling

10.1007/s11033-023-08311-w

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Citations (10)

Correlation between HDL2, HDL3 and serum ferritin levels with fatty liver and NAFLD activity score (NAS) in liver histology of organ donors

BMC Gastroenterology (2021)

Saman Nikeghbalian Rasoul Rahimi Hamed Nikoupour Neda Soleimani Sina Vakili

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is one of the most important liver diseases. High-density lipoprotein (HDL) has anti-atherogenic properties and its reduction can be associated with fatty liver. Serum ferritin levels are usually elevated in patients with NAFLD. This study aimed to evaluate the correlation between HDL subtypes and serum ferritin levels with evidence of NAFLD in liver histology of organ donors. Methods One hundred organ donor patients who were eligible for the study were included in the study and ferritin; HDL2 and HDL3 were measured in blood samples. Donated liver tissue biopsy specimens were evaluated for fatty liver and NAFLD activity score (NAS). In addition, AST and ALT were measured in recipients 24 h after transplant. All data abstracted and analyzed statistically. Results Serum HDL2 levels and HDL2/HDL3 ratio in patients with NAS > 1 were significantly lower ( P < 0.05). Serum levels of HDL3 and ferritin were not significantly associated with NAS >1 ( P > 0.05). In addition, serum ferritin > 1000 ng/ml in organ donors associated with increased AST and ALT levels 24 h after transplantation in the liver organ recipient. Conclusions Lower HDL2 values and HDL2/HDL3 ratio were associated with increased NAFLD activity score, but HDL3 and ferritin did not show such a relationship. In addition, higher levels of ferritin in organ donors may be associated with increased AST and ALT 24 h after liver transplantation in the organ recipient.

10.1186/s12876-021-01958-4

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Citations (3)

Non-apoptotic cell death programs in cervical cancer with an emphasis on ferroptosis

Critical Reviews in Oncology/Hematology (2023)

Mohammad Samare‐Najaf Ali Samareh Amir Savardashtaki Nastaran Khajehyar Amir Tajbakhsh

Pyroptosis

10.1016/j.critrevonc.2023.104249

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Citations (10)

Harnessing the therapeutic potential of mesenchymal stem/stromal cell-derived extracellular vesicles as a novel cell-free therapy for animal models of multiple sclerosis

Experimental Neurology (2023)

Morteza Jafarinia Majid Reza Farrokhi Sina Vakili Maryam Hosseini Maryam Azimzadeh

Cell therapy

Stem Cell Therapy

Encephalomyelitis

10.1016/j.expneurol.2023.114674

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Comparison of Estrogen and/or Progesterone on the Oxidative Status in Different Female Cancer Cells

Journal of Infertility and Reproductive Biology (2024)

Neda Mohammadi Asma Neisy Alireza Karimian Sina Vakili Fatemeh Zal

Background: Oxidative stress has a key role in the development of most types of cancers. Among all the conditions which affect the antioxidant defenses, the effect of using oral contraception pills (OCP) or sex hormone therapy in women during menopause is still an unsolved issue. Objectives: In the present study, the effect of estrogen (EST) alone, progesterone (PRO) alone and EST+PRO together on oxidative status in HeLa, MCF-7 and OVCAR-3 cell lines was investigated. Methods: HeLa, MCF- 7 and OVCAR-3 cell lines were treated with 1μM of EST, PRO and EST+PRO confirmed by MTT and used for 24 hour treatment. Then, catalase (CAT), glutathione (GSH), glutathione peroxidase (GPX), glutathione reductase (GR) activities and Malondialdehyde (MDA) levels were assayed in the cell lysate. Results: The results of the present study indicated that EST, PRO, and their combination were strongly able to increase the antioxidant enzymes activity compared with controls and significantly decreased the MDA levels in all three cell lines. Conclusion: The data suggest that female sex hormones and OCPs might exert antioxidant effects in different cancerous organs.

10.18502/jirb.v12i4.17974

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Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population

BMC Cardiovascular Disorders (2018)

Hamed Akbari Gholamreza Asadikaram Hamid Aria Saba Fooladi Sina Vakili

Klotho, possibly an age-regulating protein, is considered an important factor contributing to the lifespan and pathophysiology of hypertension and coronary artery disease (CAD). The present study was carried out aiming to investigate the association of Klotho-rs564481 (C1818T) gene polymorphism with hypertension and CAD. A total of 286 CAD-suspicious subjects were entered into this case-control study. The polymorphism was investigated in hypertensive patients with no CAD (H-Tens, n = 60); hypertensive patients with CAD (CAD + H-Tens, n = 95); CAD patients with no hypertension (CAD, n = 61); and non-hypertensive non-CAD subjects, which were regarded as the control group (Ctrl, n = 70). Genotype and allele frequencies were assessed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. A significant difference was found in allele frequency of Klotho C1818T among the four research groups (P = 0.03). It was also found that wild-type homozygote subjects were negatively associated with hypertension as compared to heterozygote ones (OR = 0.07 [95% CI: 0.008–0.69] P = 0.02). Moreover, in the subgroups older than 57 years old, dominant genetic model demonstrated a negative association with CAD combined with hypertension (OR = 0.31 [95% CI: 0.10–0.95] P = 0.04). In conclusion, Klotho C1818T variant may be associated with a decreased risk of hypertension. Moreover, aging enhanced positive effects of the Klotho polymorphism on CAD combined with hypertension, indicating the possibility that the KLOTHO gene might play a part in the age-related occurrence of CAD combined with hypertension.

Klotho

Heterozygote advantage

10.1186/s12872-018-0971-5

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Citations (18)

A comparative study on the effect of blood collection tubes on stress oxidative markers

PLoS ONE (2022)

Alireza Bastin Saba Fooladi Amir Hossein Doustimotlagh Sina Vakili Amir Hashem Aminizadeh

Oxidative stress has a major role in disease pathogenesis. However, limited studies have investigated the effect of various sample collection tubes on oxidative biomarkers. The present study aimed to evaluate the effect of different collection tubes on the variation of malondialdehyde (MDA), nitric oxide (NO), total thiol (t-SH), and ferric reducing ability of plasma (FRAP) levels. A total of 35 individuals participated in this study and each collected sample was separated into three different tubes: glass tubes (GTs), plain plastic tubes (PTs), and gel separator tubes (GSTs). The results of PTs and GSTs were compared to those of GTs as the reference tube. The comparison between the means of biomarkers in various tubes indicated that there was no significant difference in MDA results between tubes. In contrast, t-SH and NO content were significantly decreased in GSTs and PTs compared to GTs. However, the Bland-Altman analysis showed an acceptable concordance for the mentioned analytes and the statistically significant differences were not clinically significant for NO, MDA, and t-SH antioxidant parameters. Moreover, the FRAP level was considerably lower in GSTs compared to GTs. Nevertheless, the Bland-Altman analysis showed a high bias percentage for the FRAP assay when using PTs and GSTs. According to the present results, it can be concluded that switching to plastic blood collection tubes or serum separation tubes could influence the FRAP results. However, there was no interference for the interpretation of other antioxidant assays in different types of collection tubes. Hence, it is suggested to use GTs for total antioxidant capacity evaluations, especially the FRAP assay.

Malondialdehyde

10.1371/journal.pone.0266567

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Citations (9)

Clarifying the role of noncoding RNAs in cardiac fibrosis

Fatemeh Yousefi Zahra Shabaninejad Sina Vakili Maryam Derakhshan Ahmad Movahedpour

Cardiac Fibrosis

10.21203/rs.3.rs-100960/v1

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