Zahra Shabaninejad

Tarbiat Modares University

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Ahmad Movahedpour

Yasuj University of Medical Sciences

Mortaza Taheri‐Anganeh

Urmia University

Hamed Mirzaei

Kashan University of Medical Sciences

Amir Savardashtaki

Shiraz University of Medical Sciences

Seyyed Hossein Khatami

Shahid Beheshti University of Medical Sciences

Amir Savardashtaki

Shiraz University of Medical Sciences

Younes Ghasemi

Shiraz University of Medical Sciences

Hassan Ghasemi

Shahed University

Pegah Mousavi

Hormozgan University of Medical Sciences

Fatemeh Yousefi

Tabriz University of Medical Sciences

Cooperative Institutions

Shiraz University of Medical Sciences

Tehran University of Medical Sciences

Tarbiat Modares University

Shahid Beheshti University of Medical Sciences

Kashan University of Medical Sciences

Mashhad University of Medical Sciences

Iran University of Medical Sciences

Shiraz University

University of Tehran

Ahvaz Jundishapur University of Medical Sciences

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Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy

Cell Biochemistry and Function (2022)

Ahmad Movahedpour Omid Vakili Masoomeh Khalifeh Pegah Mousavi Amir Mahmoodzadeh

Abstract Traumatic brain injury (TBI) is one of the most concerning health issues in which the normal brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of consciousness, amnesia, focal neurological defects, alteration in mental state, and destructive diseases of the nervous system such as cognitive impairment, Parkinson's, and Alzheimer's disease. Parkinson's disease is a chronic progressive neurodegenerative disorder, characterized by the early loss of striatal dopaminergic neurons. TBI is a major risk factor for Parkinson's disease. Existing therapeutic approaches have not been often effective, indicating the necessity of discovering more efficient therapeutic targets. The mammalian target of rapamycin (mTOR) signaling pathway responds to different environmental cues to modulate a large number of cellular processes such as cell proliferation, survival, protein synthesis, autophagy, and cell metabolism. Moreover, mTOR has been reported to affect the regeneration of the injured nerves throughout the central nervous system (CNS). In this context, recent evaluations have revealed that mTOR inhibitors could be potential targets to defeat a group of neurological disorders, and thus, a number of clinical trials are investigating their efficacy in treating dementia, autism, epilepsy, stroke, and brain injury, as irritating neurological defects. The current review describes the interplay between mTOR signaling and major CNS‐related disorders (esp. neurodegenerative diseases), as well as the mTOR signaling–TBI relationship. It also aims to discuss the promising therapeutic capacities of mTOR inhibitors during the TBI.

10.1002/cbf.3692

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microRNA in inflammatory bowel disease at a glance

European Journal of Gastroenterology & Hepatology (2020)

Vahab Alamdari-Palangi Farzaneh Vahedi Zahra Shabaninejad Sadat Dokeneheifard Ahmad Movehedpour

Inflammatory bowel disease (IBD) as a chronic inflammation in colon and small intestine has two subtypes: ulcerative colitis (UC) and Crohn’s disease (CD). Genome studies have shown that UC and CD are related to microRNAs (miRNAs) expression in addition to environmental factors. This article reviews important researches that have recently been done on miRNAs roles in CD and UC disease. First, miRNA is introduced and its biogenesis and function are discussed. Afterward, roles of miRNAs in inflammatory processes involved in IBD are showed. Finally, this review proposes some circulating and tissue-specific miRNAs, which are useful for CD and UC fast diagnosis and grade prediction. As a conclusion, miRNAs are efficient diagnostic molecules especially in IBD subtypes discrimination and can be used by microarray and real time PCR methods for disease detection and classification.

Inflammatory Bowel Diseases

10.1097/meg.0000000000001815

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Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Journal of Ovarian Research (2019)

Zahra Shabaninejad Asma Vafadar Ahmad Movahedpour Younes Ghasemi Afshin Namdar

Circular RNAs (circRNAs) are a class of long non-coding RNAs (lncRNAs) which have a circular and closed loop structure. They are ubiquitous, stable, conserved and diverse RNA molecules with a range of activities such as translation and splicing regulation, which are able to interacting with RNA-binding proteins and specially miRNA sponge. The expression patterns of the circRNAs exhibited tissue specificity and also, step and stage specificity. Accumulating evidences approved the critical role of circular RNAs in many cancers such as ovarian cancer. Given that these molecules exert their effects through multiple cellular and molecular mechanisms (i.e., angiogenesis, apoptosis, growth, and metastasis) which are involved in cancer pathogenesis, circular RNAs, in particular, act by controlling cell proliferation in ovarian cancer, so that, it has been shown that the deregulation of these molecules is associated with initiation and progression of ovarian cancer. Therefore, they are attractive molecules which have introduced them as cancer biomarkers. Moreover, they could be used as new therapeutic candidates for developing novel treatment strategies. Here, for first time, we have provided a comprehensive review on the recent knowledge of circular RNAs and their pathological roles in the ovarian cancer.

Circular RNA

10.1186/s13048-019-0558-5

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DNA Binding and Cytotoxic Effects of Two Double Rollover Cycloplatinated (II) Complexes on Cancer Cell Lines

SSRN Electronic Journal (2022)

Zahra Shabaninejad Maryam Nikkhah S. Masoud Nabavizadeh

In this study, The DNA binding capacity and cytotoxic effects of two double rollovers cycloplatinated complexes, [Pt2(μ-bpy2H)(CF3COO)2(PPh3)2] and [Pt2(μ-bpy-2H)(I)2(PPh3)2] denoted as C1 and C2, respectively, were evaluated. The intrinsic binding constant (Kb) of C1 and C2 to DNA, as determined by UV-Visible spectroscopy were 29 ×104 M-1, and 54 ×104 µM-1, respectively. The calculated Stern-Volmer quenching constants (Ksv) for C1 and C2 were 3.5 × 103 M-1and 12 × 103 M-1, respectively. The interaction of the complexes with DNA is suggested to be intercalative. The cytotoxic effects of complexes in compare to cisplatin were evaluated on different cancer cell lines by MTT assay. Interestingly, C2 showed the highest cytotoxicity on A2780R, a cisplatin resistant cell line. Induction of apoptosis by the complexes was proved by flowcytometry. In all the studied cell lines, the extent of apoptosis induced by C2 was comparable or higher than cisplatin. Cisplatin induced more necrosis in all the cancer cell lines in the tested concentration.

Rollover (web design)

10.2139/ssrn.4310880

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Exosomal noncoding RNAs in prostate cancer

Clinica Chimica Acta (2022)

Ahmad Movahedpour Seyyed Hossein Khatami Neda Karami Omid Vakili Parisa Naeli

Exosome

10.1016/j.cca.2022.10.018

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Clarifying the role of noncoding RNAs in cardiac fibrosis

Fatemeh Yousefi Zahra Shabaninejad Sina Vakili Maryam Derakhshan Ahmad Movahedpour

Cardiac Fibrosis

10.21203/rs.3.rs-100960/v1

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Review of electrochemical and optical biosensors for testosterone measurement

Biotechnology and Applied Biochemistry (2022)

Maryam Nikkhah Sajedeh Karami Seyyed Hossein Khatami Mortaza Taheri‐Anganeh Amir Savardashtaki

Abstract Testosterone is an anabolic steroid and a major sex hormone in males. It plays vital roles, including developing the testis, penis, and prostate, increasing muscle and bone, and sperm production. In both men and women, testosterone levels should be in normal ranges. Besides, testosterone and its analogs are major global contributors to doping in sport. Due to the importance of testosterone testing, novel, accurate biosensors have been developed. This review summarizes the various methods for testosterone measurement. Also, recent optical and electrochemical approaches for the detection of testosterone and its analogs have been discussed.

10.1002/bab.2354

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Biosensors for detection of Tau protein as an Alzheimer's disease marker

International Journal of Biological Macromolecules (2020)

Mehrdad Ameri Zahra Shabaninejad Ahmad Movahedpour Amirhossein Sahebkar Soheila Mohammadi

Tau protein

Clinical Diagnosis

10.1016/j.ijbiomac.2020.06.239

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Citations (68)

Designing a Secretory form of RTX-A as an Anticancer Toxin: An In Silico Approach

Recent Patents on Biotechnology (2024)

Mortaza Taheri‐Anganeh Navid Nezafat Saba Gharibi Seyyed Hossein Khatami Farzaneh Vahedi

Cancer is a leading cause of death and a significant public health issue worldwide. Standard treatment methods such as chemotherapy, radiotherapy, and surgery are only sometimes effective. Therefore, new therapeutic approaches are needed for cancer treatment. Sea anemone actinoporins are pore-forming toxins (PFTs) with membranolytic activities. RTX-A is a type of PFT that interacts with membrane phospholipids, resulting in pore formation. The synthesis of recombinant proteins in a secretory form has several advantages, including protein solubility and easy purification. In this study, we aimed to discover suitable signal peptides for producing RTX-A in Bacillus subtilis in a secretory form.

10.2174/0118722083267796231210060150

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In Silico, in Vitro, and in Vivo Investigations of Anticancer Properties of a Novel Platinum (Ii) Complex and its Plga Encapsulated Form

Zahra Shabaninejad Mahdiyar Dehshiri Sayed Mostafa Modarres Mousavi Maryam Nikkhah Sajad Moradi

PLGA

10.2139/ssrn.4937814

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