Vincent Béringue

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

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Laëtitia Herzog

Université Paris-Saclay

Fabienne Reine

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Hubert Laude

Virologie et Immunologie Moléculaires

Mohammed Moudjou

Université de Versailles Saint-Quentin-en-Yvelines

Jean-Luc Vilotte

Génétique Animale et Biologie Intégrative

Human Rézaei

Université de Versailles Saint-Quentin-en-Yvelines

Bruno Passet

Université Paris-Saclay

Annick Le Dur

Virologie et Immunologie Moléculaires

Human Rezaei

University Medical Center Hamburg-Eppendorf

Olivier Andréoletti

Interaction Hôtes Agents Pathogènes

Cooperative Institutions

Centre National de la Recherche Scientifique

172

Inserm

136

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

126

Université Paris-Saclay

118

Institut National de la Recherche Agronomique

104

Virologie et Immunologie Moléculaires

Université Paris Cité

Sorbonne Université

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Génétique Animale et Biologie Intégrative

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Optimization and evaluation of new decontamination procedures inactivating human prions

Journal of Hospital Infection (2025)

Laëtitia Herzog Fabienne Reine Johan Castille Bruno Passet Mohammed Moudjou

Prions are protein-only infectious agents for which no prophylactic or curative treatment exists. Infectivity bioassays based on hamster-263K prions allowed to identify processes capable of inactivating prions on medical devices. However, a 2016 publication study revealed that detergent formulations effective against hamster strain had poor efficacy against human strains. Shortly after, three probable cases of accidental Creutzfeldt-Jakob disease underscored the risk for scientists, health workers, and patients exposed to contaminated materials. The governmental guidelines were modified and emphasizing the need for formulations effective against human prions and robust in vitro and in vivo evaluation protocols. Here, we aimed to compare infectivity bioassays with those of their PMCA counterparts to propose a robust method for evaluating prionicide treatments against human prions. Stainless steel wires were contaminated with two humanized prion strains. The wires were then treated with different protocols based on a new formulation termed TFD Premium and WHO references. Residual prion seeding activity and infectivity on the wire and in wastewater were quantified using mb-PMCA and ad hoc bioassays. For vCJD, PMCA compared humanized prions and a human-derived prion isolate. TFD Premium proved more efficient at decontaminating humanized prions than 1 N NaOH for 1 hour at room temperature. Tg650-sCJD-VV2 were more resistant to inactivation than vCJD prions. For vCJD, strain from both sources shown similar resistant profile against TFD Premium. Finally, there was perfect alignment between the highly sensitive PMCA cell-free assay and the bioassays.

Human decontamination

10.1016/j.jhin.2024.12.013

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Marked influence of the route of infection on prion strain apparent phenotype in a scrapie transgenic mouse model

Neurobiology of Disease (2010)

Christelle Langevin Olivier Andréoletti Annick Le Dur Hubert Laude Vincent Béringue

Neuropathology

Strain (injury)

Pathogenesis

10.1016/j.nbd.2010.09.010

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Citations (54)

Dynamics of prion replication and structural diversification

Vincent Béringue Angélique Igel‐Egalon Florent Laferrière Mathieu Merzach Tina Knäpple

Replication

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Caractérisation de l’hétérogénéité structurale des prions

Agnès Le Saux Vincent Béringue Human Rezaei Jan Bohl Angélique Igel‐Egalon

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Prion Diseases in Animals and Zoonotic Potential

Food Safety (2016)

Juan María Torres Alba Marín‐Moreno Olivier Andréoletti Juan Carlos Espinosa Vincent Béringue

Dietary exposure to Bovine Spongiform Encephalopathy (BSE) contaminated bovine tissues is considered as the origin of variant Creutzfeldt-Jakob disease (vCJD) in humans. To date, BSE agent is the only recognized zoonotic prion. Despite the variety of transmissible spongiform encephalopathy (TSE) agents that have been circulating for centuries in farmed ruminants, there is no apparent epidemiological link between exposure to ruminant products and the occurrence of other form of TSE in human like sporadic Creutzfeldt-Jakob disease (sCJD). However, the zoonotic potential of the diversity of circulating TSE agents has never been systematically assessed. The major issue in experimental assessment of TSEs zoonotic potential lies in the modelling of the "species barrier," the biological phenomenon that limits TSE agents' propagation from one species to another. In the past decade, mice genetically engineered to express normal forms of the human prion protein have proven to be essential in studying human prions pathogenesis and modelling the capacity of TSEs to cross the human species barrier.

Bovine spongiform encephalopathy

Zoonosis

Transmissible spongiform encephalopathy

10.14252/foodsafetyfscj.2016021

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Evaluation of anti-prion drug potency in primary nerve cell cultures infected by prions from various species Prions 2006: Strategies, advances and trends towards protection of society

HAL (Le Centre pour la Communication Scientifique Directe) (2020)

Sabrina Cronier Vincent Béringue Anaïs Bellon M Fontes Jean-Luc Vilotte

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The dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics

iScience (2024)

Basile Fornara Angélique Igel Vincent Béringue Davy Martin Pierre Sibille

Prion diseases, or transmissible spongiform encephalopathies (TSEs), are neurodegenerative disorders caused by the accumulation of misfolded conformers (PrP

Replication

Dynamics

10.1016/j.isci.2024.111381

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Involvement of Macrophages in the Pathogenesis of Transmissible Spongiform Encephalopathies

Journal of Immunology Research (2002)

Vincent Béringue Patrick Couvreur Dominique Dormont

Although transmissible spongiform encephalopathies (TSE) or prion diseases are neurodegenerative disorders, the immune system is also involved, at least in the early stages of their pathogenesis. Extensive studies have focused on cells targeted by the TSE agent for its replication but few on the possible involvement of macrophages in its clearance, as in more conventional diseases. This review summarises some of the experiments aimed at demonstrating a role for macrophages in TSE and presents the application to TSE of the macrophage "suicide" technique, which has been used to clarify the implication of these cells in the early steps of TSE pathogenesis.

Pathogenesis

Transmissible spongiform encephalopathy

10.1080/10446670290030981

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Citations (14)

Assessment of prion infectivity distribution in primate blood among cell fractions

Christelle Jas-Duval Vincent Béringue Emmanuel Comoy Fabien Aubry Valérie Durand

Infectivity

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Obtention et utilisation d'un panel de souris transgéniques dédié à l'analyse des souches de prions.

HAL (Le Centre pour la Communication Scientifique Directe) (2008)

Jean-Luc Vilotte Nathalie Chênais Gaëlle G. Tilly Bruno Passet S. Soulier

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