Djalma Menezes de Oliveira

Southwest Bahia State University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Rosane Moura Aguiar

Universidade do Estado da Bahia

Lucienir Pains Duarte

Universidade Federal de Minas Gerais

Tânia Maria de Almeida Alves

Fundação Oswaldo Cruz

Betânia Barros Cota

Fundação Oswaldo Cruz

Carlos Leomar Zani

Fundação Oswaldo Cruz

Sidney Augusto Vieira Filho

Universidade Federal de Ouro Preto

Valfredo Azevedo Lemos

Southwest Bahia State University

Marcos Almeida Bezerra

Southwest Bahia State University

Vilisaimon da Silva de Jesus

Universidade do Estado da Bahia

Susana Johann

Universidade Federal de Minas Gerais

Cooperative Institutions

Universidade Federal de Minas Gerais

Southwest Bahia State University

Fundação Oswaldo Cruz

Universidade Federal da Bahia

Universidade do Estado da Bahia

Universidade Federal de Ouro Preto

Universidade Estadual de Santa Cruz

Centro Universitário de Belo Horizonte

Universidade Estadual de Feira de Santana

Federal University of São João del-Rei

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

CCDC 936625: Experimental Crystal Structure Determination

The Cambridge Structural Database (2015)

Rodrigo S. Corrêa Lucienir Pains Duarte Grácia D. F. Silva Djalma Menezes de Oliveira Javier Ellena

10.5517/cc10fmqs

Cite

Citations (0)

Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp.

Zeitschrift für Naturforschung C (2018)

Djalma Menezes de Oliveira Cristiane B. Pereira Graziele Mendes J. Junker Markus Kolloff

The endophytic fungus Mycosphaerella sp. (UFMGCB2032) was isolated from the healthy leaves of Eugenia bimarginata, a plant from the Brazilian savanna. Two novel usnic acid derivatives, mycousfuranine (1) and mycousnicdiol (2), were isolated from the ethyl acetate extract, and their structure was elucidated by NMR and MS analyses. Compounds 1 and 2 exhibited moderate antifungal activities against Cryptococcus neoformans and Cryptococcus gattii, each with minimum inhibitory concentration values of 50.0 μg/mL and 250.0 μg/mL, respectively.

Mycosphaerella

Usnic acid

Endophyte

10.1515/znc-2017-0162

Cite

Citations (11)

CCDC 936437: Experimental Crystal Structure Determination

The Cambridge Structural Database (2015)

Rodrigo S. Corrêa Lucienir Pains Duarte Grácia D. F. Silva Djalma Menezes de Oliveira Javier Ellena

10.5517/cc10ffnj

Cite

Citations (0)

Combined experimental powder X-ray diffraction and DFT data to obtain the lowest energy molecular conformation of friedelin

Química Nova (2012)

Djalma Menezes de Oliveira Wagner da Nova Mussel Lucienir Pains Duarte Grácia Divina de Fátima Silva Hélio A. Duarte

Friedelin molecular conformers were obtained by Density Functional Theory (DFT) and by ab initio structure determination from powder X-ray diffraction. Their conformers with the five rings in chair-chair-chair-boat-boat, and with all rings in chair, are energy degenerated in gas-phase according to DFT results. The powder diffraction data reveals that rings A, B and C of friedelin are in chair, and rings D and E in boat-boat, conformation. The high correlation values among powder diffraction data, DFT and reported single-crystal data indicate that the use of conventional X-ray diffractometer can be applied in routine laboratory analysis in the absence of a single-crystal diffractometer.

Friedelin

Diffractometer

Conformational isomerism

Powder Diffraction

Cyclohexane conformation

10.1590/s0100-40422012001000005

Cite

Citations (19)

Chemical Composition and Larvicidal Activity of Essential Oil Extracted from Anemia tomentosa (SAV.) Sw: Study Conducted in vitro and in silico

Journal of the Brazilian Chemical Society (2024)

Vilisaimon de Jesus Juliana Lago Leite Jailan S. Sousa Fabrício Santos Barbosa Djalma Menezes de Oliveira

The essential oil extracted from Anemia tomentosa (EOAT) has shown larvicidal potential against Aedes aegypti, based on methods in vitro and in silico. Chromatographic and spectrometric techniques (gas chromatography-mass spectrometry (CG-MS), gas chromatography-flame ionization detector (GC-FID)), as well as mono and bidimensional nuclear magnetic resonance spectroscopy (NMR) were used to assess 10 essential oil components. Chemical composition of essential oil comprised 87.51% sesquiterpenes, with emphasis on presilphiperfolan-1-ol (42.13%) and silphiperfol-5-ene (19.47%). Larvicidal assay conducted in vitro with EOAT has evidenced potential cytotoxic activity up to 48 h exposure to it; mortality rate observed for A. aegypti larvae exposed to essential oil reached 100%. Study conducted in silico with chemical compounds deriving from the herein investigated plant species has evidenced its potential to inhibit acetylcholinesterase in A. aegypti. Activity of triquinane sesquiterpenes ranging from -6.8 to -8.2 kcal mol-1 stood out in comparison to that of temephos (-7.5 kcal mol-1). Chemical compounds identified in the investigated essential oil presented low human and environmental toxicity, as observed in absorption, distribution, metabolism and excretion, and toxicity (ADMETox) predictions.

10.21577/0103-5053.20240127

Cite

Citations (0)

Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis

Revista Brasileira de Farmacognosia (2012)

Betânia Barros Cota Ezequias Pessoa de Siqueira Djalma Menezes de Oliveira Tânia Maria de Almeida Alves Marcos Sobral

Many phenolic compounds such as xanthones, quinones and coumarins have been isolated from Kielmeyera species; however the presence of flavonoids have been showed in other genera in the Calophylleae tribe as Caraipa, Mesua and Calophyllum. Six known glycosidic flavonoids: quercetin 3-β-O-galactopyranoside (1), quercetin 3-β-O-glucopyranoside (2), quercetin 3-O-α-rhamnoside (3), luteolin 6-C-β-glucopyranoside (4), isovitexin (5), kaempferol 3-O-α-rhamnoside (6) and one triterpene, lupenone (7) were isolated, for the first time, from organic crude extract of Kielmeyera variabilis Mart. & Zucc., Calophyllaceae, leaves. The crude organic extract from K. variabilis leaves exhibited 95% of leishmanidal activity at 20 µg/mL on amastigote-like form of Leishmania (Leishmania) amazonensis in vitro model and only compound 3 showed 40-45% of growth inhibition at concentration ranging from 0.78 to 20 µg/mL. In addition, quercetin 3-O-α-rhamnoside (quercitrin) was found to be the major metabolite. Our results and previous reports suggest that synergistic effects of flavonoid glycosides are the cause of significant leishmanidal activity of the crude organic extract from K. variabilis leaves.

Quercus variabilis

10.1590/s0102-695x2012005000095

Cite

Citations (11)

New cassane diterpenes from Caesalpinia echinata

Fitoterapia (2011)

Betânia Barros Cota Djalma Menezes de Oliveira Ezequias Pessoa de Siqueira Elaine M. Souza–Fagundes Adriano M.C. Pimenta

An investigation of the ethanolic extract from stems of Caesalpinia echinata Lam (Leguminosae-Caesalpinioideae) led to the isolation of five new cassane diterpenes along with known lambertianic acid. Their structures were determined based on spectroscopic methods. A preliminary study on leishmanicidal activity demonstrated that compounds 1, 2 and 6 were found to inhibit the growth of amastigote-like forms of Leishmania amazonensis without affecting mononuclear cells obtained from human peripheral blood.

Caesalpinia

Amastigote

Caesalpinioideae

10.1016/j.fitote.2011.05.014

Cite

Citations (29)

ChemInform Abstract: Platypodiol a Novel Clerodane Diterpene from Baccharis platypoda.

ChemInform (2015)

Carolina Paula de Souza Moreira Djalma Menezes de Oliveira Cláudia N. Santos Carlos Leomar Zani Tânia Maria de Almeida Alves

10.1002/chin.201506232

Cite

Citations (0)

Endophytic fungal compounds active against Cryptococcus neoformans and C. gattii

The Journal of Antibiotics (2015)

Cristiane B. Pereira Djalma Menezes de Oliveira Alice F. S. Hughes Markus Kohlhoff Mariana L.A. Vieira

Cryptococcus gattii

Broth microdilution

10.1038/ja.2015.11

Cite

Citations (29)

Anti-Allergic Potential of Herbs and Herbal Natural Products - Activities and Patents

Recent Patents on Endocrine Metabolic & Immune Drug Discovery (2012)

Betânia Barros Cota Caryne Margotto Bertollo Djalma Menezes de Oliveira

The increase of allergic diseases has accompanied the global population growth and the major challenge is to reduce morbidity. The currently available treatments present limitations regarding efficacy and safety. Hence, patients with chronic allergic conditions seek alternatives to achieve better control of symptoms. Many natural products have been identified as potential anti-allergic agents. In addition, plant formulations have demonstrated, in general, to be safe in clinical trials and demonstrate additional effects along with Western medicines such as synergism and modulation of the immune system. It is known that plants represent a source of new therapeutic agents and some of them have shown mechanisms of action similar to synthetic agents. However, in general, herbs and their combination are patented mainly by Asian countries to be used in food and drinks or cosmetics and dietary supplements and the anti-allergic mechanisms of action are not yet fully elucidated. In this review, we highlight relevant patent and studies with cultivated plants, plant formulations, and secondary metabolites that have been evaluated with respect to its anti-allergic potential. Keywords: Anti-allergic, complementary alternative medicine, natural product, patent, plant, herbal products, ALLERGIC CONDITIONS, prostaglandin D2 synthase, phenolics, antiallergic effects, food allergy, Secondary Metabolites

10.2174/18722148130103

Cite

Citations (1)