Khurshed Bozorov

Xinjiang Technical Institute of Physics & Chemistry

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Haji Akber Aisa

Xinjiang Technical Institute of Physics & Chemistry

Jiangyu Zhao

Xinjiang Technical Institute of Physics & Chemistry

Lifei Nie

Xinjiang Technical Institute of Physics & Chemistry

Burkhon Elmuradov

Yunusov Institute of the Chemistry of Plant Substances

Li Fei Nie

Xinjiang Technical Institute of Physics & Chemistry

Buer Song

Xinjiang Technical Institute of Physics & Chemistry

Guozheng Huang

Anhui University of Technology

Chao Niu

Xinjiang Technical Institute of Physics & Chemistry

Rustamkhon Kuryazov

Urgench State University

Zukela Ruzi

University of Chinese Academy of Sciences

Cooperative Institutions

Chinese Academy of Sciences

Xinjiang Technical Institute of Physics & Chemistry

University of Chinese Academy of Sciences

Yunusov Institute of the Chemistry of Plant Substances

Academy of Sciences Republic of Uzbekistan

National University of Uzbekistan

Samarkand State University named after Sharof Rashidov

Xinjiang Institute of Engineering

Tashkent Institute of Irrigation and Agricultural Mechanization Engineers

Urumqi Vocational University

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Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: Synthesis and in vitro biological evaluation. Part 1

European Journal of Medicinal Chemistry (2014)

Khurshed Bozorov Hairong Ma Jiangyu Zhao Haiqing Zhao Hua Chen

HeLa

IC50

10.1016/j.ejmech.2014.07.065

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Citations (36)

Thieno[2,3-d]pyrimidin-4-ones 1. Condensation of 2,3-dimethyl- and 2,3-tri-, 2,3-tetra-, and 2,3-pentamethylene-7,8-dihydro-pyrrolo[1,2-a]thieno[2,3-d]pyriminidin-4(6H)-ones with aromatic aldehydes and furfural

Chemistry of Heterocyclic Compounds (2011)

Burkhon Elmuradov Khurshed Bozorov Kh. М. Shakhidoyatov

Tetra

Benzaldehyde

10.1007/s10593-011-0677-4

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Citations (16)

ChemInform Abstract: Recent Developments Regarding the Use of Thieno[2,3‐d]pyrimidin‐4‐one Derivatives in Medicinal Chemistry, with a Focus on Their Synthesis and Anticancer Properties

ChemInform (2015)

Khurshed Bozorov Jiang‐Yu Zhao Burkhon Elmuradov Apar Pataer Haji Akber Aisa

Abstract Review: 91 refs.

10.1002/chin.201544263

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Design, combinatorial synthesis and cytotoxic activity of 2-substituted furo[2,3-d]pyrimidinone and pyrrolo[2,3-d]pyrimidinone library

Molecular Diversity (2022)

Buer Song Lifei Nie Khurshed Bozorov Rustamkhon Kuryazov Jiangyu Zhao

HeLa

Pyrimidinones

Cancer cell lines

10.1007/s11030-022-10529-y

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Citations (9)

CCDC 1528441: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Li Fei Nie Khurshed Bozorov Chao Niu Guozheng Huang Haji Akber Aisa

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1n9gkz

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Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties

European Journal of Medicinal Chemistry (2015)

Khurshed Bozorov Jiang-Yu Zhao Burkhon Elmuradov Apar Pataer Haji Akber Aisa

Quinazoline

Anticancer drug

10.1016/j.ejmech.2015.08.018

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Citations (78)

Synthesis of Diethyl 2,5-Diaminothiophene-3,4-dicarboxylate Derivatives and Antitumor Activity Study

Chinese Journal of Organic Chemistry (2023)

Weishu Zhang Lifei Nie Khurshed Bozorov Haji Akber Aisa Jiangyu Zhao

a,b ( a 中国科学院新疆理化技术研究所新疆特有药用资源利用重点实验室乌鲁木齐 830011) ( b 中国科学院大学北京 100049) ( c 撒马尔罕国立大学化学学院撒马尔罕乌兹别克斯坦 140104) 摘要以含硫杂环噻吩为母核, 设计并合成了 30 个 2,5-二氨基噻吩-3,4-二羧酸二乙酯衍生物, 经 1 H NMR、 13 C NMR 和 HRMS 进行了结构确证.用噻唑蓝(MTT)法测定该系列化合物对 HeLa(人宫颈癌)、HT-29(人结肠癌)、A549(人非小细胞肺癌)、HepG2(人肝癌)四种肿瘤细胞的体外抗增殖活性.结果表明, 部分化合物表现出良好的抗增殖活性, 其中 2-(4-(三氟甲氧基)苯甲酰胺基-5-(5-硝基噻吩-2-基)亚甲基氨基噻吩-3,4-二羧酸二乙酯(C25)对 HT-29、A549 两种肿瘤细胞均表现出明显的抗增殖活性, IC50 值分别为(0.35±0.07)和(0.66±0.09)μmol/L; 2-(3-(三氟甲基)苯甲酰胺基)-5-(5-硝基噻吩-2-基)亚甲基氨基噻吩-3,4-二羧酸二乙酯(C29)对 HT-29、HepG2 两种肿瘤细胞也表现出明显的抗增殖活性, IC50 值分别为(0.47±0.03)和(0.41±0.04)

10.6023/cjoc202210040

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Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines

Research on Chemical Intermediates (2019)

Azizbek Nasrullaev Khurshed Bozorov Khayrulla Bobakulov Jiangyu Zhao Li Fei Nie

Hydrazone

Tricyclic

Quinazoline

Hydrazine (antidepressant)

10.1007/s11164-018-03731-x

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Citations (12)

Synthesis and biological evaluation of novel sulfonamide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones on melanin synthesis in murine B16 cells

Research on Chemical Intermediates (2017)

Li Fei Nie Khurshed Bozorov Chao Niu Guozheng Huang Haji Akber Aisa

Moiety

Sulfonamide

Tricyclic

Vitiligo

10.1007/s11164-017-3023-3

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Citations (17)

Diversity-oriented synthesis of amide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and evaluation of their influence on melanin synthesis in murine B16 cells

Heterocyclic Communications (2018)

Li Fei Nie Guozheng Huang Khurshed Bozorov Jiangyu Zhao Chao Niu

Abstract A diversity-oriented synthesis of amide-containing thieno[2,3- d ]pyrimidin-4(3 H )-ones is reported. All compounds were tested for their influence on melanin synthesis in murine B16 cells. The azepine fragment in thieno[2,3- d ]pyrimidin-4(3 H )-one skeleton significantly increases the melanin content.

Tricyclic

Amide

Azepine

10.1515/hc-2017-0256

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Citations (21)