Yinting Yu

Nanjing University of Chinese Medicine

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Huanjin Liu

Nanjing University of Chinese Medicine

Chenxu Wei

Nanjing University of Chinese Medicine

Mengyu Guo

National Center for Nanoscience and Technology

Chunmei Mei

Nanjing University of Chinese Medicine

Wenxin Wang

University College Dublin

Huixian Chen

Guangxi Subtropical Crops Research Institute

Xunhong Liu

Nanjing University of Chinese Medicine

Tulin Lu

Nanjing University of Chinese Medicine

Weidong Li

State Administration of Traditional Chinese Medicine of the People's Republic of China

Changcan Shi

University of Chinese Academy of Sciences

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Nanjing University of Chinese Medicine

University of Chinese Academy of Sciences

Chinese Academy of Sciences

State Administration of Traditional Chinese Medicine of the People's Republic of China

Beijing University of Chinese Medicine

Nanjing University

China Pharmaceutical University

Guangdong Pharmaceutical University

Beijing University of Chemical Technology

Xinxiang Medical University

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Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17/Treg balance and gut microbiota structure

Gut Microbes (2023)

Mengyu Guo Huanjin Liu Yinting Yu Xingyu Zhu Hui Xie

Background With increasing knowledge about the gut – bone axis, more studies for treatments based on the regulation of postmenopausal osteoporosis by gut microbes are being conducted. Based on our previous work, this study was conducted to further investigate the therapeutic effects of Lactobacillus rhamnosus GG (LGG) on ovariectomized (OVX) model rats and the immunological and microecological mechanisms involved.Results We found a protective effect of LGG treatment in OVX rats through changes in bone microarchitecture, bone biomechanics, and CTX-I, PINP, Ca, and RANKL expression levels. LGG was more advantageous in promoting osteogenesis, which may be responsible for the alleviation of osteoporosis. Th17 cells were imbalanced with Treg cells in mediastinal lymph nodes and bone marrow, with RORγt and FOXP3 expression following a similar trend. TNF-α and IL-17 expression in colon and bone marrow increased, while TGF-β and IL-10 expression decreased; however, LGG treatment modulated these changes and improved the Th17/Treg balance significantly. Regarding the intestinal barrier, we found that LGG treatment ameliorated estrogen deficiency-induced inflammation and mucosal damage and increased the expression of GLP-2 R and tight junction proteins. Importantly, 16S rRNA sequencing showed a significant increase in the Firmicutes/Bacteroidetes ratio during estrogen deficiency. Dominant intestinal flora showed significant differences in composition; LGG treatment regulated the various genera that were imbalanced in OVX, along with modifying those that did not change significantly in other groups with respect to the intestinal barrier, inflammation development, and bile acid metabolism.Conclusions Overall, LGG ameliorated estrogen deficiency-induced osteoporosis by regulating the gut microbiome and intestinal barrier and stimulating Th17/Treg balance in gut and bone.

Lactobacillus rhamnosus

Osteopenia

Dysbiosis

10.1080/19490976.2023.2190304

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Citations (80)

Anti-arrhythmia potential of honey-processed licorice in zebrafish model: Antioxidant, histopathological and tissue distribution

Journal of Ethnopharmacology (2023)

Wenxin Wang Yinting Yu Huixian Chen Peijun Sun Lujie Lu

Cardiotoxicity

Isoliquiritigenin

10.1016/j.jep.2023.116724

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A graphene oxide-loaded processed pyritum composite hydrogel for accelerated bone regeneration via mediation of M2 macrophage polarization

Materials Today Bio (2023)

Changcan Shi Yinting Yu Hongjuan Wu Huanjin Liu Mengyu Guo

A coordinated interaction between osteogenesis and the osteoimmune microenvironment plays a vital role in regulating bone healing. However, disturbances in the pro- and anti-inflammatory balance hinder the therapeutic advantages of biomaterials. In this study, a novel composite hydrogel was successfully fabricated using graphene oxide (GO)-loaded processed pyritum (PP) in combination with poly(ethylene glycol) diacrylate (PEGDA) and carboxymethyl chitosan (CMC). Subsequently, the immunomodulatory effects and bone regenerative potential of PP/GO@PEGDA/CMC were investigated. The results demonstrated that the PP/GO@PEGDA/CMC hydrogel possessed excellent mechanical properties, swelling capacity, and stability. Moreover, PP/GO@PEGDA/CMC prominently promoted M2 polarization and increased the levels of anti-inflammatory factors (interleukin (IL)-4, IL-10, and transforming growth factor-β). These beneficial effects facilitated the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells in vitro. Additionally, the in vivo results further verified that the implantation of PP/GO@PEGDA/CMC markedly reduced local inflammation while enhancing bone regeneration at 8 weeks post-implantation. Therefore, the results of this study provide potential therapeutic strategies for bone tissue repair and regeneration by modulating the immune microenvironment.

Macrophage polarization

10.1016/j.mtbio.2023.100753

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Study on the removal effect and mechanism of calcined pyrite powder on Cr(VI)

International Journal of Phytoremediation (2023)

Xingyu Zhu Shuli Chen Huanjin Liu Xiaofang Hu Chenxu Wei

AbstractPyrite exhibits considerable potential as an adsorbent in wastewater treatment. However, few pyrite adsorbents are directly obtained from natural pyrite, as most are composite materials that require a complex preparation process. To develop a pyrite-based adsorbent with a simple preparation process, pyrite was processed by calcination at 400, 600, and 800 °C for 4 h and ball-milled into a fine powder. The adsorption properties of the pyrite powder were systematically explored. The calcined pyrite powder was characterized by SEM-EDS and XRD. The results revealed that the pyrite calcined at 600 °C exhibited excellent adsorption properties and was primarily composed of Fe7S8. The optimum conditions for Cr(VI) removal were a temperature of 45 °C, an adsorbent dosage of 1 g, an equilibration time of 60 min, and an initial pH of 3. Moreover, the calcined pyrite powder exhibited excellent reusability, and the Cr(VI) removal rate exceeded 65% after three cycles. The Cr(VI) adsorption on pyrite can be well described by the Freundlich model and pseudo-second-order kinetic equation. The calcination temperature is the main factor affecting the adsorption performance of pyrite. Therefore, the calcined pyrite powder is expected to be an excellent adsorbent for Cr(VI) in the wastewater treatment industry.NOVELTY STATEMENTPyrite has shown promising development prospects in the field of wastewater purification. However, the preparation of most pyrite-based adsorbents is complicated. Upon high-temperature calcination, pyrite is used in traditional Chinese medicine clinics to promote the healing of fractures. The efficiency and underlying mechanism of Cr(VI) adsorption from water using calcined pyrite was investigated. The adsorbent was prepared using a simple method and exhibited excellent adsorption performance, thus allowing its application in preparing ore-based adsorbents for water pollution treatment.Keywords: Mineral adsorbentphysical adsorptionredox effects AcknowledgmentsThe authors thank the Department of Jiangsu Key Laboratory of Chinese Medicine Processing for providing the research facility.Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis work was supported by the National Natural Science Foundation of China under Grand [No. 81373970] and 2023 Jiangsu Province Graduate Student Research and Practice Innovation Program Project [No. KYCX23_2052].

10.1080/15226514.2023.2246591

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Citations (3)