M. Soledade C.S. Santos

University of Lisbon

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

João Carlos R. Reis

University of Lisbon

Ester F. G. Barbosa

University of Lisbon

Rodrigo F.M. de Almeida

University of Lisbon

Ana Paula Paiva

University of Lisbon

F. J. V. Santos

University of Lisbon

Manuel E. Minas da Piedade

University of Lisbon

Miguel Machuqueiro

University of Lisbon

Joaquim T. Marquês

University of Lisbon

Filomena Martins

University of Lisbon

Ana S. Viana

University of Lisbon

Cooperative Institutions

University of Lisbon

107

Rede de Química e Tecnologia

Instituto Politécnico de Lisboa

Faculdade de Tecnologia e Ciências

Universidade Nova de Lisboa

Instituto Superior Técnico

Universidade de São Paulo

Universidade do Porto

Cornell University

Lusíada University of Lisbon

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Interactions of selected flavonoids with NaDS micelles

Springer eBooks (2004)

M. Soledade C.S. Santos Sara Lacerda Ester F. G. Barbosa

Dissociation constant

Aggregation number

10.1007/978-3-540-36462-7_18

Cite

Citations (2)

In vitro Evaluation of Isoniazid Derivatives as Potential Agents Against Drug-Resistant Tuberculosis

Frontiers in Pharmacology (2022)

Joaquim T. Marquês Catarina Frazão de Faria Marina Reis Diana Machado Susana Santos

The upsurge of multidrug-resistant tuberculosis has toughened the challenge to put an end to this epidemic by 2030. In 2020 the number of deaths attributed to tuberculosis increased as compared to 2019 and newly identified multidrug-resistant tuberculosis cases have been stably close to 3%. Such a context stimulated the search for new and more efficient antitubercular compounds, which culminated in the QSAR-oriented design and synthesis of a series of isoniazid derivatives active against Mycobacterium tuberculosis . From these, some prospective isonicotinoyl hydrazones and isonicotinoyl hydrazides are studied in this work. To evaluate if the chemical derivatizations are generating compounds with a good performance concerning several in vitro assays, their cytotoxicity against human liver HepG2 cells was determined and their ability to bind human serum albumin was thoroughly investigated. For the two new derivatives presented in this study, we also determined their lipophilicity and activity against both the wild type and an isoniazid-resistant strain of Mycobacterium tuberculosis carrying the most prevalent mutation on the katG gene, S315T. All compounds were less cytotoxic than many drugs in clinical use with IC 50 values after a 72 h challenge always higher than 25 µM. Additionally, all isoniazid derivatives studied exhibited stronger binding to human serum albumin than isoniazid itself, with dissociation constants in the order of 10 −4 –10 −5 M as opposed to 10 −3 M, respectively. This suggests that their transport and half-life in the blood stream are likely improved when compared to the parent compound. Furthermore, our results are a strong indication that the N′ = C bond of the hydrazone derivatives of INH tested is essential for their enhanced activity against the mutant strain of M. tuberculosis in comparison to both their reduced counterparts and INH.

10.3389/fphar.2022.868545

Cite

Citations (4)

Stability and safety of quercetin-loaded cationic nanoemulsion: In vitro and in vivo assessments

Colloids and Surfaces A Physicochemical and Engineering Aspects (2016)

Michelli Ferrera Dario Camila Areias de Oliveira Lorena Rigo Gaspar Catarina Rosado Inês F. A. Mariz

Biocompatibility

Cationic polymerization

Thermal Stability

Zeta potential

10.1016/j.colsurfa.2016.07.010

Cite

Citations (40)

Short communication: Anesthetic residues in milk after topical application during treatment of hoof lesions in dairy cows

Journal of Dairy Science (2019)

George Stilwell A.M. Ferrador M. Soledade C.S. Santos J.M. Domingues

Hoof

Milking

10.3168/jds.2019-17160

Cite

Citations (1)

Differential targeting of membrane lipid domains by caffeic acid and its ester derivatives

Free Radical Biology and Medicine (2017)

Hugo A. L. Filipe Carla Sousa Joaquim T. Marquês Diogo Vila‐Viçosa António de Granada-Flor

POPC

Lipid microdomain

Sphingolipid

10.1016/j.freeradbiomed.2017.12.002

Cite

Citations (49)

Thermodynamic evaluation of molar surface area and thickness of water + ethanol mixtures

Journal of Molecular Liquids (2018)

M. Soledade C.S. Santos João Carlos R. Reis

Mole fraction

10.1016/j.molliq.2018.01.136

Cite

Citations (13)

Lipophilicity assessment of some isoniazid derivatives active against Mycobacterium tuberculosis

Colloids and Surfaces A Physicochemical and Engineering Aspects (2020)

M. Soledade C.S. Santos Ana M. Matos Marina Reis Filomena Martins

Lipophilicity

Octanol

Micellar solutions

Aqueous two-phase system

10.1016/j.colsurfa.2020.124820

Cite

Citations (6)

What happens when the surface and bulk phases of liquid metal alloys attain the same density at equilibrium?

Materials Today Communications (2020)

M. Soledade C.S. Santos João Carlos R. Reis

Liquid metal

Component (thermodynamics)

10.1016/j.mtcomm.2020.100932

Cite

Citations (4)

Studies on the density, heat capacity, surface tension and infinite dilution diffusion with the ionic liquids [C4mim][NTf2], [C4mim][dca], [C2mim][EtOSO3] and [Aliquat][dca]

Fluid Phase Equilibria (2010)

C. A. Nieto de Castro Elisa Langa Ana Lucia Ferreira de Morais Manuel Matos Lopes Maria José Lourenço

C4mim

Dicyanamide

Dilution

10.1016/j.fluid.2010.03.010

Cite

Citations (186)

Apparent Molar Volumes ofN,N– Disubstituted Monoamides: A Convenient Tool to Interpret Iron(Iii) Extraction Profiles from Hydrochloric Acid Solutions

Solvent Extraction and Ion Exchange (2013)

Lília C. Ribeiro M. Soledade C.S. Santos Ana Paula Paiva

Abstract New iron(III) extraction data involving two N,N-disubstituted monoamides, N-ethyl-N-phenyloctanamide (EPHOA) and N-ethyl-N-cyclohexyloctanamide (ECHOA), from hydrochloric acid media, are presented and discussed. These, and earlier results obtained with other similar N,N-disubstituted monoamides, are interpreted in this work through their apparent molar volumes in 1,2-dichloroethane, and all the information is being used to screen for solute-solute and solute-diluent interactions. The results collected help to understand why N-cyclohexyl monoamides are generally more efficient than their N-phenyl analogues as liquid-liquid extractants for iron(III) from 3 to 5 M hydrochloric acid solutions, and clearly denote that N-phenyl monoamides are essentially monomeric whereas N-cyclohexyl monoamide derivatives have a tendency to aggregate in the organic solution. Keywords: Apparent molar volumes N,N-disubstituted monoamidesiron(III)chloride media ACKNOWLEDGMENTS Thanks are due to J. M. Nogueira and collaborators (CQB, DQB-FCUL) for the use of GC-MS facilities, and to FCT (PEst-OE/QUI/UI0612/2011) for financial support.

Hydrochloric acid

Diluent

1,2-Dichloroethane

Molar ratio

10.1080/07366299.2013.764784

Cite

Citations (7)