Elio Pietro Perrone

Sapienza University of Rome

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M. Forlino

Sapienza University of Rome

A. De Santis

German Cancer Research Center

P. Ferrari

Sapienza University of Rome

Daniela Urosa Maggi

University of Salento

M. Mazzotta

Sapienza University of Rome

Mara Riminucci

Sapienza University of Rome

Martina Carbone

University of Udine

Laura Cesini

St. Eugenio Hospital

Pierleone Lucatelli

Sapienza University of Rome

Alessandro Corsi

Sapienza University of Rome

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Sapienza University of Rome

Policlinico Umberto I

Istituti di Ricovero e Cura a Carattere Scientifico

Agostino Gemelli University Polyclinic

University of L'Aquila

National Institutes of Health

American College of Gastroenterology

St. Eugenio Hospital

University of Salento

Central University of Venezuela

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Acute hepatitis-like presentation with cholestasis of CBFB–MYH11-positive acute myeloid leukemia in an adult male: a case report

Journal of Medical Case Reports (2022)

Irene Spinelli A. De Santis Laura Cesini Mara Riminucci Alessandro Corsi

Abstract Background Liver involvement in adults with acute myeloid leukemia is uncommon. Most of the case reports describe acute liver failure or obstructive jaundice, while acute hepatitis is rarely mentioned. We report a patient with acute myeloid leukemia who presented with clinical, biochemical, and radiological signs of acute hepatitis that totally regressed after chemotherapy. Case presentation A 38-year-old Caucasian man presented with fever, cough, and mild fatigue. Laboratory workup showed anemia, thrombocytopenia, severe leukocytosis, transaminitis, and hyperbilirubinemia. Imaging of the abdomen (ultrasound and magnetic resonance) showed hepatomegaly, splenomegaly, upper limits portal veins diameters, increased thickness of the gallbladder wall, and significant abdominal lymph nodes. Peripheral blood smear and bone marrow evaluation were consistent with acute myeloid leukemia, and liver biopsy showed massive sinusoidal and portal infiltration by leukemic cells. After remission-inducing chemotherapy, there was complete normalization of liver function tests, and liver, spleen, and portal vein size. Conclusions This case highlights the importance of taking acute myeloid leukemia into account as a possible cause of liver damage to make a rapid diagnosis and start appropriate treatment that may lead to hematological remission and hepatic dysfunction resolution.

Leukocytosis

10.1186/s13256-022-03476-7

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Radiomic analysis of pretreatment imaging in hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE): treatment response and survival

Endoscopy (2023)

Elio Pietro Perrone Pierleone Lucatelli Bianca Rocco P. Ferrari I. Spinelli

Aims Radiomics uses radiological imaging to generate multi-dimensional data, defined as features. The novelty of radiomics is the possible correlation with clinical endpoints, mostly in oncological diseases. We present results of a retrospective study investigating correlations between pretreatment imaging radiomics and clinical outcomes in Patients (Pts.) with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE).

10.1055/s-0043-1765439

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Application of acoustic radiation force impulse elastography in non-invasive diagnosis of focal nodular hyperplasia

Journal of Hepatology (2020)

M. Forlino Irene Spinelli Elio Pietro Perrone Martina Carbone Daniela Urosa Maggi

Acoustic Radiation Force

10.1016/s0168-8278(20)31260-5

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