Md Sadaqul Islam Sikder

National Institute of Cardiovascular Diseases

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Md Mamunur Rashid

Universiti Brunei Darussalam

Iftekhar Alam

National Institute of Cardiovascular Diseases

Lipi Debnath

National Institute of Cardiovascular Diseases

Khandaker Shaheed Hossain

National Institute of Cardiovascular Diseases

Mir Jamal Uddin

National Institute of Cardiovascular Diseases

Md Monir Hossain Khan

National Institute of Cardiovascular Diseases

Bijan Kumar Nath

Newaz Ahmed

The University of Texas Southwestern Medical Center

Tanzia Tahfim

Shaheed Suhrawardy Medical College

Laila Sultana

Dhaka Medical College and Hospital

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National Institute of Cardiovascular Diseases

Dhaka Medical College and Hospital

Sir Salimullah Medical College

Universiti Brunei Darussalam

Bangladesh University of Textiles

Ibrahim Cardiac Hospital & Research Institute

Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders

Universitas Ibrahimy

The University of Texas Southwestern Medical Center

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Implantation of Permanent Pacemaker and COVID-19 coinfection: Strategy for Management at a Dedicated Cardiac Hospital in Bangladesh

Bangladesh Heart Journal (2022)

Iftekhar Alam Khandaker Shaheed Hossain Md Mamunur Rashid Newaz Ahmed Lipi Debnath

Background: The pandemic existence of corona virus disease 2019 (COVID -19) in the year 2020 has initially limited the number of intervention in cardiac diseases in our country. The need for placement of permanent pacemaker is a medical emergency but in patients with concomitant COVID -19, it’s a double edged sword. The treatment strategy and planning for this group of patients with high degree atrioventricular block (AVB) or sinus node disease (SND), needing permanent pacemaker is the fundamental concern along with the safety of the attending cardiologists and other staff members. In this study we sought to comprehend the treatment strategies in patients requiring pacemaker with simultaneous COVID-19 co-infection. Methods: This study was done at the National institute of cardiovascular diseases (NICVD), Shere Bangla Nagar, Dhaka from 10th March 2020 to 9th September 2020. During these six months all patients waiting for permanent pacemaker implantation were screened for COVID-19 by real time polymerase chain reaction (RT PCR). The positive cases were included in the study and managed according to the in hospital protocol. Results: A total of 98 patients had permanent pacemaker implanted during this period, among them12 patients (12.24%) were tested positive for COVID-19. Average age of the patients was 68±7.6 years and 66.7% was male and 33.3% was female. The mean duration of RT PCR positive status was 20.6±6.4 days (range 14 to 29 days) and the mean duration of indwelling TPM was 21.25±7.05 days (range 17 to 30 days). There was no TPM related complication following PPM implantation. Conclusions: Conservative approach of medical management with TPM for stabilization of the patients with corona virus disease is a safe option for delayed PPM implantation after improvement of the patients. In hospital treatment protocol with facilities for isolation and treatment of COVID is the mainstay of the treatment strategy. Bangladesh Heart Journal 2022; 37(1): 59-64

Concomitant

Permanent pacemaker

Atrioventricular block

10.3329/bhj.v37i1.60105

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Relationship between Serum Magnesium & Lipid Profile in Type 2 Diabetic Patients with and without Foot Ulcer

Scholars Journal of Applied Medical Sciences (2023)

Laila Sultana Md Sadaqul Islam Sikder Tanzia Tahfim

DBackground: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder associated with various complications, including foot ulcer. Dyslipidemia and hypomagnesemia are common in T2DM patients and may contribute to the development of complications. This study aimed to investigate the relationship between serum magnesium level and lipid profile in T2DM patients with and without foot ulcer. Methods: This cross-sectional study was conducted at the Department of Biochemistry and Molecular Biology, BIRDEM Academy, Dhaka, Bangladesh, involving 120 T2DM patients. Participants were divided into two groups: Group A (T2DM patients with foot ulcer, n=60) and Group B (T2DM patients without foot ulcer, n=60). Serum magnesium level and lipid profile were measured, and their correlations were analyzed. Result: Significant differences were observed between the two groups in terms of serum magnesium level and lipid profile. Group A had a higher prevalence of hypomagnesemia (69.6%) compared to Group B (30.4%). Elevated level of total cholesterol, triacylglycerol, and LDL cholesterol were also observed in Group A. A significant positive correlation was found between serum magnesium level and total cholesterol and LDL cholesterol in Group A, while no significant correlation was observed in Group B. Conclusion: The study revealed that T2DM patients with foot ulcers are more likely to have hypomagnesemia and dyslipidemia compared to those without foot ulcer. A significant correlation between serum magnesium level and lipid profile was observed in patients with foot ulcer. These findings may have important implications for the management and prevention of complications in T2DM patients and warrant further investigation through longitudinal studies.

Dyslipidemia

Lipid Profile

Diabetic foot ulcer

Metabolic disorder

10.36347/sjams.2023.v11i09.020

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Comparative Assessment of Serum Homocysteine and High Sensitivity C-reactive Protein in type 2 Diabetic and non Diabetic Patients with ACS

Bangladesh Heart Journal (2021)

Lipi Debnath Abdul Wadud Chowdhury Iftekhar Alam Md Mamunur Rashid Md Sadaqul Islam Sikder

Background: Increased level of serum homocysteine (Hcy) and high sensitivity C-reactive protein (hs-CRP) have a proven implication with epithelial injury leading to coronary artery disease ((CAD). These are strongly associated with different metabolic syndrome variables, although different studies have shown both positive and negative responses when correlated with type 2 diabetes malitus (T2DM). In this study we explored the role of these markers of CAD in type II diabetic and non diabetic patients with newly diagnosed acute coronary syndrome (ACS) at a tertiary care hospital among Bangladeshi population. Methods: We wanted to identify whether Hcy and hs- CRP link positively or negatively with type 2 diabetes in this cross sectional observentional study. A total of 260 patients with new onset ACS were included in the study, out of which 72 patients with T2DM and 188 patients without diabetes were considered as group I and group II respectively. Clinical and biochemical data were compared in between the groups. Results: The mean age of the study population was 50.33±15.50 years and 45.86±18.76 years in group I and II respectivly. Male female ratio was 4:1 among the whole study subjects. There was significantly higher level of serum homocysteine in group II than group I 18.41±15.49 μmol/L vs. 14.11±6.48 μmol/L respectively (p <0.05). Similarly hs-CRP in group I was 26.84±30.30 mg/L and in group II 37.48±37.99mg/L, higher in group II (p<0.05). Both Hcy and hs-CRP were higher in male and female patients in group II. Dyslipidaemia was significant risk factor in group I and smoking in group II (p<0.05). Conclusion: In patients with ACS serum Hcy and hs-CRP were significantly higher in non-daibetic patients then in patients with type 2 diabetes. This association may be population or ethenicity specific which provide further scope for future elaborate studies. Bangladesh Heart Journal 2020; 35(2) : 114-120

Population study

10.3329/bhj.v35i2.52897

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