Junn-Liang Chang

National Defense Medical Center

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Shih Sheng Jiang

National Health Research Institutes

Chao A. Hsiung

National Health Research Institutes

Kuang-Ting Liu

Taoyuan Armed Forces General Hospital

Shu‐Chen Liu

Beijing Radiation Center

Jyh‐Lyh Juang

National Health Research Institutes

Chih‐Hung Wang

National Changhua University of Education

Yueh-Ching Chang

Taoyuan Armed Forces General Hospital

Yee‐Min Jen

Tao Yuan General Hospital

An-Chun Lee

University of Kansas Medical Center

Shih-Hsin Hsiao

Taipei Medical University Hospital

Cooperative Institutions

National Defense Medical Center

National Yang Ming Chiao Tung University

Taoyuan Armed Forces General Hospital

Tri-Service General Hospital

National Health Research Institutes

Chang Gung Memorial Hospital

Chang Gung University

National Taiwan University

Taipei Medical University

China Medical University

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Unusually aggressive primary testicular diffuse large B-cell lymphoma initially presenting as systemic disseminating metastases in older adult men: a case report

Annals of Medicine and Surgery (2023)

Kuang-Ting Liu Yueh-Ching Chang Yu‐Chieh Lin Junn-Liang Chang

Primary testicular lymphoma (PTL) accounts for 1-2% of all nonHodgkin lymphomas (NHL), 4% of extranodal nonHodgkin lymphomas, and ~9% of testicular malignancies. A rare subtype of PTL is primary testicular diffuse large B-cell lymphoma (PT-DLBCL), which may initially present as disseminating metastasis in older adult males and has a poor prognosis.Herein, the authors describe the case of a 64-year-old man with the chief complaint of a painless unilateral scrotal mass. Computed tomography scans of the abdomen and a pelvic examination demonstrated a left testicular tumor with multiple lymphadenopathies partially aggregated in the para-aortic area and disseminated to multiple soft tissues and organs. Subsequently, the patient underwent a left radical orchiectomy. Pathological and immunohistochemical examinations confirmed the diagnosis of left PT-DLBCL with systemic disseminating metastases.PTL often aggressively spreads to other extranodal organs, such as the contralateral testis, central nervous system, lung, pleura, Waldeyer's ring, and soft tissues. In men over 60 years of age, PT-DLBCL is the most common testicular malignancy. However, extensive systemic metastasis as the initial presentation is extremely rare. PT-DLBCL has a dismal prognosis and requires radical orchiectomy followed by multimodal therapy and central nervous system prophylaxis or systemic intervention to improve survival.The diagnosis of PT-DLBCL through preoperative and imaging examinations is often challenging. Thus, histopathology and immunohistochemical markers play a crucial and valuable role in the definite diagnosis and differential diagnosis of PTLs.

Orchiectomy

Histopathology

10.1097/ms9.0000000000001018

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Mantle Cell Lymphoma Presenting as Acute Abdominal Syndrome: A Rare Case Report and Literature Review

Healthcare (2021)

Fu-Chou Lee Junn-Liang Chang Hung-Ming Chen Wan‐Chen Tsai Po-Jen Hsiao

Acute abdominal syndrome can be caused by several possible reasons. The most common causes are perforation of a gastroduodenal ulcer, peritonitis, intestinal obstructions, and perforation of an appendix or fallopian tube. Fever and pain can be caused by an appendicitis or sigmoiditis. Appendiceal lymphoma is a rare disease that is usually found incidentally during appendectomy. Most of the cases are non-Hodgkin's lymphomas. Mantle cell lymphoma is an aggressive B-cell non-Hodgkin's lymphoma with a poorer prognosis than other B-cell lymphomas; thus, a definitive diagnosis is essential.

10.3390/healthcare9081000

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The role of uric acid for predicting future metabolic syndrome and type 2 diabetes in older people

The journal of nutrition health & aging (2016)

Junn-Liang Chang Y.-L. Chen Yi-Jen Hung Chang‐Hsun Hsieh C. H. Lee

Although it is known that high uric acid (UA) level is associated with type 2 diabetes (T2DM) and metabolic syndrome (MetS), most of the previous studies were focused on adults. Since aging becomes a major problem for many societies, in this longitudinal study, we investigated the role of UA in future T2DM and MetS in a large cohort of people who were older than 65 years.

Longitudinal Study

10.1007/s12603-016-0749-3

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Perioperative outcomes after pancreatoduodenectomy for ampullary carcinoma: A 9-year experience from a tertiary referral centre in the UK

HPB (2019)

Junn-Liang Chang Vasileios Mavroeidis M. Soo A. Gibbs P. Osuri

Pancreatic fistula

10.1016/j.hpb.2019.10.835

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Supplementary Figure Legends for S1-S16 from Expression of Neuroendocrine Factor VGF in Lung Cancer Cells Confers Resistance to EGFR Kinase Inhibitors and Triggers Epithelial-to-Mesenchymal Transition

Wen Hwang Yu‐Fan Chiu Ming-Han Kuo Kuan-Lin Lee An-Chun Lee

<p>'Figure S1. Lack of T790M and amplification of MET in HCC827GR cells; Figure S2. VGF-expressing cells are resistant to rociletinib; Figure S3. VGF expression in neuroendocrine carcinoma and EGFR-TKI resistant cells; Figure S4. VGF is expressed in the independently selected EGFR-TKI resistant HCC827 pool; Figure S5. Correlation of VGF levels with EGFR-TKI resistance and EMT in EGFR-TKI selected single cell clones; Figure S6. Effect of VGF expression on cell survival; Figure S7. VGF is highly expressed in small cell lung cancer; Figure S8. VGF is highly expressed in large cell neuroendocrine carcinoma; Figure S9. Correlation of VGF, CEACAM6, SYP, and CHGB expression levels with IC50 values of gefitinib in EGFR-mutated lung cancer cell lines; Figure S10. EGFR-TKI resistance in H1975 cells expressing differential VGF levels; Figure S11. VGF-TWIST1 signaling encourages EGFR-TKI resistance; Figure S12. Effect of conditioned medium from VGF expressing cells on low serum-mediated growth; Figure S13. Effect of doxycycline alone on tumor cell growth in vitro and in vivo; Figure S14. Correlation of VGF with EMT markers in lung adenocarcinoma; Figure S15. Correlation of neuroendocrine markers or TWIST1 with survival in lung adenocarcinoma; Figure S16. Correlation of neuroendocrine markers or VGF-TWIST1 signature with survival in EGFR-mutated lung adenocarcinoma.'</p>

Neuroendocrine differentiation

10.1158/0008-5472.22413936.v1

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Associations Between Lifestyle Factors and Reduced Kidney Function in US Older Adults: NHANES 1999–2016

International Journal of Public Health (2021)

Horng‐Jinh Chang Kuan-Reng Lin Meng-Te Lin Junn-Liang Chang

Objective: This study aimed to evaluate the associations between lifestyle factors and the estimated glomerular filtration rate (eGFR) levels in older adults by analyzing the United States National Health and Nutrition Examination Survey data (1999–2016). Methods: A total of 10,052 eligible participants were divided into two groups: reduced eGFR group (eGFR < 60 ml/min/1.73 m 2 ) and normal group (eGFR ≥ 60 ml/min/1.73 m 2 ). The primary factors were physical activity, alcohol consumption, smoking, and comorbidities. Results: Multivariable analysis revealed that older age, proteinuria, cardiovascular disease, diabetes, hyperuricemia, and hypertension were significantly associated with higher odds of reduced kidney function. Sufficient physical activity, current alcohol consumption, and being a current smoker were significantly associated with lower odds of reduced kidney function. However, subgroup analysis by sex revealed that the effects of proteinuria, current alcohol consumption, and sufficient physical activity were sex-specific. Conclusion: Several risk and beneficial factors for reduced kidney function in adults aged 65 and above in the United States were identified, but some of them might be sex-specific. Further studies are warranted to confirm these findings in other populations and countries.

Odds

10.3389/ijph.2021.1603966

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Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression

BMC Genomic Data (2018)

I‐Hsuan Lin Junn-Liang Chang Kate Hua Wan‐Chen Huang Ming‐Ta Hsu

Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of muscle mass, quality and strength. Age-related muscle loss (sarcopenia) is an important health problem associated with the aged population. We investigated the alteration of genome-wide transcription in mouse skeletal muscle tissue (rectus femoris muscle) during aging using a high-throughput sequencing technique. Analysis revealed significant transcriptional changes between skeletal muscles of mice at 3 (young group) and 24 (old group) months of age. Specifically, genes associated with energy metabolism, cell proliferation, muscle myosin isoforms, as well as immune functions were found to be altered. We observed several interesting gene expression changes in the elderly, many of which have not been reported before. Those data expand our understanding of the various compensatory mechanisms that can occur with age, and further will assist in the development of methods to prevent and attenuate adverse outcomes of aging.

10.1186/s12863-018-0660-5

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Synchronous diffuse large B-cell lymphoma masquerading as jejunojejunal intussusception with unexplained pleural effusion in elderly male: A rare manifestation

Authorea (Authorea) (2021)

Junn-Liang Chang Kuang-Ting Liu Yueh-Ching Chang

The primary gastrointestinal lymphoma is uncommon. This is a confirmed case of synchronous primary diffuse large B-cell lymphoma manifested as jejunojejunal intussusception with lymph nodal and pleural metastasis. Its clinical manifestations, morphological characteristics, immunophenotypes, and molecular biological characteristics are very different, which is the biggest challenge before surgery.

10.22541/au.163255551.14051798/v1

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Topical photosan-mediated photodynamic therapy for DMBA-induced hamster buccal pouch early cancer lesions: an in vivo study

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2011)

Yih‐Chih Hsu Walter Hong‐Shong Chang Junn-Liang Chang Kuang-Ting Liu Chun‐Pin Chiang

Oral cancer has becomes the most prominent cancer disease in recent years in Taiwan. The reason is the betel nut chewing habit combing with smoking and alcohol-drinking lifestyle of people results in oral cancer becomes the fastest growth incident cancer amongst other major cancer diseases. In previous studies showed that photosan, haematoporphyrin derivative (HPD), has demonstrated effective PDT results on human head and neck disease studies. To avoid the systemic phototoxic effect of photosan, this study was designed to use a topical photosan-mediated PDT for treatment of DMBA-induced hamster buccal pouch cancerous lesions. DMBA was applied to one of the buccal pouches of hamsters thrice a week for 10 to 12 weeks. Cancerous lesions were induced and proven by histological examination. These DMBA-induced cancerous lesions were used for testing the efficacy of topical photosan-mediated PDT. Before PDT, fluorescence spectroscopy was used to determine when photosan reached its peak level in the lesional epithelial cells after topical application of photosan gel. We found that photosan reached its peak level in cancerous lesions about 13.5 min after topical application of photosan gel. The cancerous lesions in hamsters were then treated with topical photosan-mediated PDT (fluence rate: 600 mW/cm²; light exposure dose 200 J/cm²) using the portable Lumacare 635 nm fiber-guided light device. Visual examination demonstrated that topical photosan-mediated PDT was an applicable treatment modality for DMBA-induced hamster buccal pouch cancerous lesions.

Cheek pouch

10.1117/12.879555

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Data from Expression of Neuroendocrine Factor VGF in Lung Cancer Cells Confers Resistance to EGFR Kinase Inhibitors and Triggers Epithelial-to-Mesenchymal Transition

Wen Hwang Yu‐Fan Chiu Ming-Han Kuo Kuan-Lin Lee An-Chun Lee

<div>Abstract<p>Mutations in EGFR drive tumor growth but render tumor cells sensitive to treatment with EGFR tyrosine kinase inhibitors (TKI). Phenotypic alteration in epithelial-to-mesenchymal transition (EMT) has been linked to the TKI resistance in lung adenocarcinoma. However, the mechanism underlying this resistance remains unclear. Here we report that high expression of a neuroendocrine factor termed VGF induces the transcription factor TWIST1 to facilitate TKI resistance, EMT, and cancer dissemination in a subset of lung adenocarcinoma cells. VGF silencing resensitized EGFR-mutated lung adenocarcinoma cells to TKI. Conversely, overexpression of VGF in sensitive cells conferred resistance to TKIs and induced EMT, increasing migratory and invasive behaviors. Correlation analysis revealed a significant association of VGF expression with advanced tumor grade and poor survival in patients with lung adenocarcinoma. In a mouse xenograft model of lung adenocarcinoma, suppressing VGF expression was sufficient to attenuate tumor growth. Overall, our findings show how VGF can confer TKI resistance and trigger EMT, suggesting its potential utility as a biomarker and therapeutic target in lung adenocarcinoma. <i>Cancer Res; 77(11); 3013–26. ©2017 AACR</i>.</p></div>

10.1158/0008-5472.c.6508854

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