Mojgan Gharipour

Isfahan University of Medical Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Nizal Sarrafzadegan

Isfahan University of Medical Sciences

Masoumeh Sadeghi

Isfahan University of Medical Sciences

Alireza Khosravi

Isfahan University of Medical Sciences

Minoo Dianatkhah

Isfahan University of Medical Sciences

Elham Khosravi

Isfahan University of Medical Sciences

Pouya Nezafati

Townsville Hospital

Roya Kelishadi

Isfahan University of Medical Sciences

Aliakbar Tavassoli

Isfahan University of Medical Sciences

Ladan Sadeghian

Isfahan University of Medical Sciences

Mahnaz Jozan

Isfahan University of Medical Sciences

Cooperative Institutions

Isfahan University of Medical Sciences

251

University of Isfahan

Cardiovascular Research Center

Tehran University of Medical Sciences

Cardiovascular Institute Hospital

Isfahan Fertility and Infertility Center

Shahrekord University of Medical Sciences

Shiraz University of Medical Sciences

Iran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Which technique is suitable for management of acute myocardial infarction following coronary artery bypass surgery, rescue percutaneous coronary intervention or open heart surgery? A case-series studies.

PubMed (2014)

Mohsen Mirmohammadsadeghi Mohammad Hashemi Majid Rabbani Mojgan Gharipour Peyman Nilfroush

One of the serious complications followingcoronary artery bypass surgery is postoperative acute myocardial infarction commonly due to graft thrombosis, kinking, or spasm. Two recommended approaches for management of this event includeRescue percutaneous coronary intervention (PCI) and urgent open heart surgery. In the present case series, we described and compared early and long-term results of rescue PCI and reoperation in patients with three-vessel coronary artery disease undergoing CABG postoperatively and suffered acute myocardial infarction.

Bypass surgery

Source

Cite

Citations (0)

The Association between Serum Lactate Level and Post CABG Complications in Cardiac Patients

DOAJ (DOAJ: Directory of Open Access Journals) (2011)

Mohsen Mirmohammadsadeghi Ali Etesampour Mojgan Gharipour Mohammad Saeidi Pouya Mirmohammadsadeghi

Association (psychology)

Source

Cite

Citations (0)

Decision support in prediction of metabolic syndrome with data mining methods

DOAJ (DOAJ: Directory of Open Access Journals) (2011)

Mahdi Edrisi Mojgan Gharipour Azadeh Faroughi Fatemeh Javeri Behrouz Shahgholi

Source

Cite

Citations (1)

Epigenetic programming of obesity in early life through modulation of the kynurenine pathway

International Journal of Obesity (2024)

Mojgan Gharipour Jeffrey M. Craig Garth Stephenson

Abstract Childhood obesity is a global health concern that has its origins before birth. Although genetics plays a crucial role, increasing evidence suggests that epigenetic modifications during fetal life could also influence its incidence. In this model, during the fetal period, interactions between genetic makeup, intrauterine factors, and environmental conditions, increase the risk of childhood obesity. This is in accordance with the Developmental Origins of Health and Disease (DOHaD) hypothesis, in which specific intrauterine environments can have long-lasting effects on the immune system’s essential functions during crucial stages of fetal growth, resulting in permanent changes to the immune function of the offspring. Consequently, dysfunction can consequently make the offspring more prone to inflammatory and immune-related disorders later in life. In this review, we examine how maternal inflammation could influence the risk of childhood obesity. We propose that during pregnancy, modification of the expression of critical genes in metabolic and signaling pathways, such as the kynurenine (Kyn) pathway, occurs due to increased levels of maternal inflammation. We also propose that such expression differences are mediated by epigenetic changes. Furthermore, we also hypothesize that the Kyn pathway produces metabolites that have immunoregulatory effects and may play a crucial role in regulating inflammation during pregnancy. As a result, interventions aimed at improving maternal inflammation may be able to help alleviate the risk of childhood obesity.

Kynurenine pathway

10.1038/s41366-024-01647-8

Cite

Citations (0)

Polymorphisms of LPA gene, rs1801693 and rs7765781, are not associated with premature myocardial infarction in the Iranian population.

PubMed (2021)

Mahsa Rahimi Hossein Khanahmad Mojgan Gharipour Hamidreza Roohafza Minoo Dianatkhah

Myocardial infarction (MI) is one of the leading causes of mortality globally. Although it is most prevalent in the elderly, it may occur in young adults (men ≤ 55 years or women ≤ 65 years) as premature MI (PMI). As awareness of genetic risks may lead to effective prevention of PMI, we aim to investigate the association of two susceptible single nucleotide polymorphisms (SNPs) in the LPA gene with PMI in the Iranian population, rs1801693 and rs7765781, identified in previous genome-wide association studies (GWAS).A total number of 85 patients with PMI and 85 healthy controls were recruited from December 2015 to March 2016 from Isfahan, Iran. Peripheral blood samples were collected from all individuals. Deoxyribonucleic acid (DNA) was extracted and genotyped at rs1181693 and rs7765781 polymorphisms, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results were statistically analyzed to find any possible association of the two polymorphisms with PMI by SPSS software and P-values less than 0.05 were considered to be statistically significant.Statistical analysis displayed no significant difference between rs1801693 (P = 0.815)/rs7765781 (P = 0.746) alleles in patients with PMI and healthy control subjects.There is no meaningful association between rs1801693/rs7765781 and PMI incidence in the Iranian population.

Genome-wide Association Study

Genetic Association

10.22122/arya.v17i0.2369

Cite

Citations (4)

Use of lipid-lowering medicinal herbs during pregnancy: A systematic review on safety and dosage.

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Hojjat Rouhi-Boroujeni Esfandiar Heidarian Hamid Rouhi-Boroujeni Minasadat Khoddami Mojgan Gharipour

Hyperlipidemia is one of the important diseases in pregnancy that causes fetal abnormalities during pregnancy and after the birth. Unfortunately, the usual anti-fat drugs are associated with high morbidity in fetus and due to people's inclination towards taking herbs, it is required to identify side effects of medicinal herbs in pregnancy. The aim of this study was to present hypolipidemic herbs that would not any complications for mother and fetus.In this review article, the major electronic databases such as EBSCO, Central Register of Controlled Trials (CENTRAL), China Network Knowledge Infrastructure (CNKI), Cochrane, Google scholar, MEDLINE, SciVerse, Scopus, and Web of Science were searched using the key words "herbal" and "hyperlipidemia", "herbal" and "pregnancy" matched by MeSH from their respective inceptions till September, 2016. Total of 1723 publications (145 review articles, 855 original research articles, and 723 abstracts) about the effect of herbals on hyperlipidemia and 682 publications (200 abstracts, 423 original research articles, and 59 review articles) about the effect of herbals in pregnancy were retrieved. At the end, a list of medicinal plants effective on hyperlipidemia alongside their effects on pregnancy was developed. Finally, the plants effective on hyperlipidemia and safe during pregnancy were determined and their dosage, complications, mechanism of action, and side effects were reported.A total of 110 effective herbs on hyperlipidemia were identified and complications of 95 plants in pregnancy were studied. At last, among the 55 selected plants effective on hyperlipidemia and examined for pregnancy, we reported 12 herbs with their dosage and special considerations that can be used to treat hyperlipidemia during pregnancy.Some medicinal plants can be used to treat hyperlipidemia during pregnancy without any significant side effects both on mother or fetus.

Hyperlipidemia

Source

Cite

Citations (9)

Is Selenium Supplementation Knockdown the Expression of SEPS1 in Patients with Metabolic Syndrome and History of Cardiovascular Disease?

Atherosclerosis Supplements (2018)

Mojgan Gharipour Mansour Salehi Masoumeh Sadeghi Mehrdad Behmanesh Rokhsareh Iranipour

Menarche

Menstruation

Medical record

10.1016/j.atherosclerosissup.2018.04.480

Cite

Citations (0)

PP.29.15

Journal of Hypertension (2015)

Mojgan Gharipour Masoumeh Sadeghi Mohammad Talaie Nizal Sarrafzadegan

Objective: This study designed to compare different obesity indicators as well as determine the best cut of point of obesity indices to incidence of HTN among Iranian population. Design and method: Isfahan Cohort Study was a longitudinal population-based study that was conducted on adults aged 35 years or older, living in urban and rural areas of three districts in central Iran. After 7 years of follow-up, 3283 participants were re-evaluated using a standard protocol similar to the baseline. At both measurements, participants underwent medical interview, physical examination, and fasting blood measurements. Participants (n = 4833) with prevalent hypertension were excluded from the analysis, resulting in a sample size of 2450. Results: The average age of subjects was increased from 47.3 ± 9.4 years in 2001 to 55.4 ± 10.3 years in 2007. After 7 years of follow-up, 542 (22.1%) new cases of HTN were found indicating cumulative incidence (95% CI) of 22.6% (20.3–24.9) in men and 21.6% (19.3–23.9) in women. Of all the anthropometric indices, WHtR was the strongest predictor of HTN in men with almost 1.6 times increase in HTN risk for each SD increase (Table 2). n women, the model that included WHtR better fitted. In the adjusted models, WHpR did not reach significant level in women. IIn men, although all central adiposity indices were independently associated with HTN except for HC, BMI lost its statistically significant association when WC or WHtR were introduced to the models. Conversely in women, WHpRand WHtRshowed a relationship independent to BMI. Height in men significantly decreased hypertension risk in crude models, but not in adjusted models and in women. ROC curve analysis showed the highest discrimination power (AUC) in WHtR for men and women (Table 5). For each anthropometric index the optimal cutoff point is presented maximizing Youden's index for incident HTN and its corresponding sensitivity and specificity in men and women. The highest positive likelihood ratio was observed in the indices with highest AUC. Conclusions: The result of this study revealed that WHtR is the preferred obesity indicator to predict hypertension among Iranian population.

Cumulative incidence

10.1097/01.hjh.0000468607.43788.df

Cite

Citations (1)

Initial clinical outcomes of intracoronary infusion of autologous progenitor cells in patients with acute myocardial infarction.

PubMed (2012)

Seyed Mohammad Hashemi Jazi Mohammad Hossein Nasr‐Esfahani Mehrafarin Fesharaki Fariba Moulavi Mojgan Gharipour

Myocardial infarction (MI) is an irreversible cardiomyocytes injury which begins after 15-20 minutes of coronary artery occlusion. The extent of infarction is modulated by a number of factors including collateral blood supplies, medications, and ischemic preconditioning. Although angioplasty and thrombolytic agents can relieve the cause of the infarction, the time from the occlusion onset to reperfusion determines the degree of irreversible myocardial injury. Experimental studies suggested that stem cells and progenitor cells derived from bone marrow can be used in the repair of cardiac tissue after acute MI. This study was designed to investigate the feasibility, safety and initial clinical outcome of intracoronary infusion of autologous progenitor cells in patients with acute MI.Patients with a history of anterior MI and a left ventricular ejection fraction (LVEF) less than 35 % who were candidates for coronary angioplasty were randomly allocated in a 1:1 ratio to either control or bone marrow cell groups (each including 16 patients). Thallium scan and 17-segment echocardiography analysis for regional wall motion abnormality were performed before and 1 and 6 months after intracoronary infusion of bone marrow cells. The same tests were also conducted for the control group at identical time intervals. Quantitative variables were compared by independent t-test and paired t-test. Statistical significance was assumed at a value of P < 0.05.LVEF in the case and control groups increased to 39.37 ± 2.47% and 31.00 ± 1.87%, respectively (P = 0.069 and 0.1, respectively). Wall motion abnormality index (WMAI) decreased insignificantly in both groups. Perfusion defect scores (PDSs) decreased significantly in the case group.In this study, autologous mesenchymal stem cell transplantation by intracoronary catheter during angioplasty in patients with a history of severe LV dysfunction caused mild increases in LVEF.

Source

Cite

Citations (9)

How Are Epigenetic Modifications Related to Cardiovascular Disease in Older Adults?

International Journal of Molecular Sciences (2021)

Mojgan Gharipour Arya Mani Mona Amini Baghbahadorani Camila Kellen de Souza Cardoso Shayesteh Jahanfar

The rate of aging has increased globally during recent decades and has led to a rising burden of age-related diseases such as cardiovascular disease (CVD). At the molecular level, epigenetic modifications have been shown recently to alter gene expression during the life course and impair cellular function. In this regard, several CVD risk factors, such as lifestyle and environmental factors, have emerged as key factors in epigenetic modifications within the cardiovascular system. In this study, we attempted to summarized recent evidence related to epigenetic modification, inflammation response, and CVD in older adults as well as the effect of lifestyle modification as a preventive strategy in this age group. Recent evidence showed that lifestyle and environmental factors may affect epigenetic mechanisms, such as DNA methylation, histone acetylation, and miRNA expression. Several substances or nutrients such as selenium, magnesium, curcumin, and caffeine (present in coffee and some teas) could regulate epigenetics. Similarly, physical inactivity, alcohol consumption, air pollutants, psychological stress, and shift working are well-known modifiers of epigenetic patterns. Understanding the exact ways that lifestyle and environmental factors could affect the expression of genes could help to influence the time of incidence and severity of aging-associated diseases. This review highlighted that a healthy lifestyle throughout the life course, such as a healthy diet rich in fibers, vitamins, and essential elements, and specific fatty acids, adequate physical activity and sleep, smoking cessation, and stress control, could be useful tools in preventing epigenetic changes that lead to impaired cardiovascular function.

10.3390/ijms22189949

Cite

Citations (21)