Haibo Wu

First Affiliated Hospital Zhejiang University

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Nanping Wu

Zhuhai People's Hospital

Hang‐Ping Yao

First Affiliated Hospital Zhejiang University

Fumin Liu

First Affiliated Hospital Zhejiang University

Linfang Cheng

Zhejiang University

Fan Yang

First Affiliated Hospital Zhejiang University

Xiaorong Peng

AstraZeneca (Singapore)

Xiuming Peng

Zhejiang University

Xiangyun Lu

Zhejiang University

Lihua Xu

ZheJiang Academy of Agricultural Sciences

Rufeng Lu

Zhejiang Chinese Medical University

Cooperative Institutions

State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation

311

Modular Genetics (United States)

299

Zhejiang University

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

State Key Laboratory of Diagnosis and Treatment of Infectious Diseases

Shanghai Jiao Tong University

First Affiliated Hospital Zhejiang University

Sun Yat-sen University

Society of Thoracic Surgeons

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Optimal Conditions for Recovery of Antibody from Immune Precipitate of Type I Pneumococcus

Experimental Biology and Medicine (1939)

S.-c. Liu Haibo Wu

There is an optimal pH for the recovery of antibody from immune precipitate of Type I pneumococcus by treatment with dilute acid or alkali. In the presence of NaCl, the percentage of recovery is increased. The mechanism of the recovery is discussed. The present findings furnish the basis of a method for the isolation of antibody which is better than any of the existing methods.

10.3181/00379727-41-10598

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Citations (4)

Longevity of protective immune responses induced by a split influenza A (H7N9) vaccine mixed with MF59 adjuvant in BALB/c mice

Oncotarget (2017)

Huilin Ou Wei Yao Dong-Shan Yu Tian-Hao Weng Frederick X.C. Wang

The influenza virus is a serious threat to public health worldwide. A novel avian influenza A (H7N9) virus with a mortality rate of approximately 30% has been identified as an unusually dangerous virus for humans by the World Health Organization. Pathogenic H7N9 continue to represent a public health concern, and several candidate vaccines are currently in development. We generated candidate H7N9 vaccine strains using reverse genetics, consisting of hemagglutinin and neuraminidase genes derived from a human H7N9 virus and the remaining genes from the PR8 (A/PuertoRico/8/34 (H1N1)) virus. This H7N9 vaccine exhibited superior efficacy when combined with MF59 compared to other adjuvants. Immunized BALB/c mice were followed to determine the duration of the protective immune response. Antibody levels decreased to between one-half and one-eighth of the peak values four months after the final dose of the vaccine. Previously vaccinated mice received an A/Zhejiang/DTID-ZJU01/2013 H7N9 challenge six months post-vaccination, and all remained protected. We also verified that MF59 enhanced the HI, MN, and IgG antibody titers to influenza antigens. The humoral immune response and Th2 cytokine production following influenza challenge was potently induced in the animals that received the split vaccine. Therefore, the split H7N9 influenza vaccine with the MF59 adjuvant could effectively induce antibody production and protect mice from H7N9 virus challenge even after six months.

Antibody titer

Vaccine efficacy

10.18632/oncotarget.20064

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Citations (9)

Isolation and molecular characterization of reassortant H11N3 subtype avian influenza viruses isolated from domestic ducks in Zhejiang Province in China

Virus Genes (2016)

Haibo Wu Xiuming Peng Xiaorong Peng Nanping Wu

Reassortment

Medical microbiology

Lineage (genetic)

Isolation

10.1007/s11262-016-1348-4

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Citations (3)

Hydrophobic Affinity Chromatography of Human Thrombin

Archives of Biochemistry and Biophysics (1993)

Roger L. Lundblad Jeng‐Yu Tsai Haibo Wu Joyce W. Jenzano G C White

Agarose

Tosyl

10.1006/abbi.1993.1187

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Citations (5)

Typical Morphological Characteristics of the Immunohistochemistrical Subtypes of Pituitary Microadenomas: A dual center study

Endocrine Connections (2024)

Li Zhang Shuai Yan Shen-ke Xie Yi-tong Wei Hua-peng Liu

Purpose: This study aimed to investigate the relation of magnetic resonance image (MRI) features and immunohistochemistrical subtypes of pituitary microadenomas (PMAs) characterized by location and growth pattern. Materials and methods: A double-center, retrospective review of MRI characteristics was conducted in 57 PMA cases recorded from February 2014 to September 2023 and identified on the basis of 2017 WHO classification of pituitary gland tumors. The geometric center of the tumor was defined, and the possibility of PMA vertical or lateral growth pattern was evaluated according to ratio of maximum diameter between the X and Y axes. Results: Among the PMAs, somatotroph adenomas (STAs) significantly frequented the lateral–anteroinferior portion of pituitary gland (P=0.036). Lactotroph adenomas (LTAs) showed significant locational preference for the lateral–posteroinferior portion (P=0.037), and gonadotroph adenomas (GTAs) were predominately located in the central–anteroinferior portion (P=0.022). Furthermore, the PMAs in the suprasellar portion exhibited vertical extension with statistical significance (P=0.0). Conclusion: In our cohort, the micro-STAs were predominately located in the lateral–anteroinferior portion of pituitary gland, the micro-LTAs in the lateral–posteroinferior portion, and the micro-GTAs in the central–anteroinferior portion. The growth pattern of the PMAs was highly correlated with their vertical position instead of their immunohistochemistrical subtypes. Therefore, MRI shows potential in differentiating partial PMA subgroups, especially the cases in silent groups.

10.1530/ec-24-0378

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Amino acid substitutions involved in the adaptation of a novel highly pathogenic H5N2 avian influenza virus in mice

Virology Journal (2016)

Haibo Wu Xiuming Peng Xiaorong Peng Nanping Wu

H5N2 avian influenza viruses (AIVs) can infect individuals that are in frequent contact with infected birds. In 2013, we isolated a novel reassortant highly pathogenic H5N2 AIV strain [A/duck/Zhejiang/6DK19/2013(H5N2) (6DK19)] from a duck in Eastern China. This study was undertaken to understand the adaptive processes that led enhanced replication and increased virulence of 6DK19 in mammals. 6DK19 was adapted to mice using serial lung-to-lung passages (10 passages total). The virulence of the wild-type virus (WT-6DK19) and mouse-adapted virus (MA-6DK19) was determined in mice. The whole-genome sequences of MA-6DK19 and WT-6DK19 were compared to determine amino acid differences. Amino acid changes were identified in the MA-DK19 PB2 (E627K), PB1 (I181T), HA (A150S), NS1 (seven amino acid extension "WRNKVAD" at the C-terminal), and NS2 (E69G) proteins. Survival and histology analyses demonstrated that MA-6DK19 was more virulent in mice than WT-6DK19. Our results suggest that these substitutions are involved in the enhanced replication efficiency and virulence of H5N2 AIVs in mammals. Continuing surveillance for H5N2 viruses in poultry that are carrying these mutations is required.

Strain (injury)

Medical microbiology

H5N1 genetic structure

10.1186/s12985-016-0612-5

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Citations (10)

Magnetic second-order topological physics in two-dimensional NiZrI6

Results in Physics (2023)

Yang Li Lunsheng Wu Shikai Zhou Haibo Wu

Two-dimensional (2D) nonmagnetic second-order topological insulators (SOTIs) have been exhaustively studied, whereas 2D magnetic SOTIs have received little attention from researchers. In this work, we have demonstrated using first-principles calculations that the 2D NiZrI6 monolayer is a 2D magnetic SOTI with a ferromagnetic ground state. Two spin channels in the 2D NiZrI6 monolayer exhibit nontrivial gaps. According to the higher-order bulk-boundary correspondence, the 2D NiZrI6 monolayer shows topologically protected corner states with quantized fractional charge (e/3) that are spin-polarized and pinned at the sample's corners in real space. In addition, the zero-dimensional corner states of the 2D NiZrI6 monolayer are resistant to spin–orbit coupling (SOC) effects. It is anticipated that 2D NiZrI6 monolayer with magnetic higher-order topology will contribute to topo-spintronics advancement.

Topological insulator

Spin–orbit interaction

10.1016/j.rinp.2023.106849

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Hourglass nodal ring phonons in two-dimensional LiHS

Results in Physics (2023)

Yang Li Lunsheng Wu Shikai Zhou Haibo Wu

Exploration of topological phonons in two-dimensional (2D) has long been regarded as one of the central topics in topological physics. Due to their distinct band dispersion, hourglass nodal rings have garnered considerable attention, but their existence in 2D materials, particularly in spinless phonon systems, has received scant attention. Using the first-principle calculations, this study shows that P4/nmm type LiHS monolayer is an ideal candidate for hosting hourglass nodal ring phonons. Moreover, the phononic edge states induced by the nodal ring phonons in LiHS are also exhibited in this work. Our work provides the first 2D material candidate to study hourglass nodal ring phonons and the phononic edge states induced by the nodal ring phonons.

Hourglass

10.1016/j.rinp.2023.106826

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Citations (1)

ISOLATION OF IMMUNOLOGICALLY PURE ANTIBODY

Science (1936)

Bacon F. Chow Haibo Wu

Isolation

10.1126/science.84.2179.316

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Citations (9)

Characterization of Novel Reassortant Influenza A (H5N2) Viruses Isolated from Poultry in Eastern China, 2015

Frontiers in Microbiology (2017)

Haibo Wu Rufeng Lu Xiuming Peng Xiaorong Peng Linfang Cheng

Recently, novel variants of H5 highly pathogenic avian influenza viruses have been frequently isolated from poultry and wild birds in Asia, Europe and North America. Live poultry markets (LPMs) play an important role in the dissemination of influenza viruses. Four H5N2 avian influenza viruses (AIVs) were isolated from poultry during surveillance of AIVs in LPMs in Eastern China, in 2015. Whole-genome sequencing, combined with phylogenetic and antigenic analyses were performed to characterize these viruses. These H5N2 viruses had undergone extensive reassortment resulting in two genetic groups of viruses in poultry. These viruses exhibited slightly pathogenicity in mice, and replicated without prior adaptation. The continued circulation of these novel H5N2 viruses may represent a threat to human health.

Reassortment

H5N1 genetic structure

10.3389/fmicb.2017.00741

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Citations (15)