Objective
To find a more convenient, safe and effective extraction method, via comparing the extraction operation effect of the embedded supernumerary teeth in maxilla by using piezosurgery osteotomy or contra-angle high speed turbines.
Methods
One hundred and fifty patients (with a total of one hundred and ninety supernumerary teeth) who had accepted the extraction operation of the embedded supernumerary teeth in maxilla at Zhongshan City People′s Hospital from 2013 to 2017 were included. They were divided into two groups randomly. All of the patients had accepted the cone beam computed tomography (CBCT) examination to locate the embedded supernumerary teeth. The experimental group underwent the teeth extraction with piezosurgery osteotomy; while the control group with contra-angle high speed turbines. The postoperative pain (quantitatively analyzed by VAS) , operation time were compared between the two groups. The data were processed and analyzed by SPSS 20.0, and the mean and standard deviation of two groups were analyzed by independent sample t test.
Results
The average VAS value in the experimental group is 4.2 ± 1.5, while the average VAS value in the control group is 5.2 ± 1.6. The postoperative pain in the experimental group is less than the control group significantly (t=-4.072, P<0.001) . In the groups of patients over 12 years old, the average VAS value in the experimental group is 4.2±1.5, while the average VAS value in the control group is 5.1±1.6. The postoperative pain in the experimental group is less than the control group significantly (t=-2.866, P= 0.005) . The average operation time of the experimental group is (48±6) min while the average operation time of the control group is (51±8) min. The operation time of the experimental group is less than the control group significantly (t=-3.014, P= 0.003) . While in the groups of patients over 12 years old, the average operation time of the experimental group is (46 ± 6) min while the average operation time of the control group is (49 ± 7) min. The difference of operation time between the two groups is not significant (t=-0.901, P= 0.060) .
Conclusions
Using the CBCT guided piezosurgery osteotomy to remove the impacted supernumerary tooth in the anterior maxilla, can lessen postoperative pain, shorten operation time, and provide more comfortable experience.
Key words:
Tooth, impacted; Tooth, supernumerary; Tooth extraction, minimally invasive; Cone beam computed tomography; Piezosurgery; Micro Power Systems
Introduction: High sodium intake is an important risk factor for hypertension and CVD. However, the basic underlying mechanisms are not well understood. Animal studies demonstrate that miRNAs play a role in high sodium intake-induced myocardial fibrosis and salt-sensitive hypertension. Hypothesis: We aim to test the hypothesis that high sodium intake induced changes in circulating miRNA expression in hypertensives. Methods: A whole genome miRNA next generation sequencing was performed in paired serum samples (pre and post slow release sodium tablets) selected from 10 black male untreated hypertensive subjects (aged 43 to 68 years) in a randomized double-blind crossover trial (slow release sodium vs placebo while on low-sodium diet). Samples were sequenced on the Illumina NextSeq 500 system. The differential expression analysis was done using the EdgeR statistical software package. Benjamini-Hochberg FDR was used to adjust for multiple comparisons. mirTarBase (version 6.0) was used to identify miRNA target genes. Results: On average 10.2 million reads were obtained per sample. miR-425-3p (1.55 folds), miR-4433-3p (1.80 folds) and miR-4433-5p (1.54 folds) were significantly upregulated with an increase in sodium intake (raw ps 0.80). miR-143-3p (0.71 folds), miR-223-5p (0.76 fold) and miR-148a-3p (0.82 folds) were significantly downregulated (raw ps 0.80). miR-425-3p was involved in cell death. miR-143-3p was previously associated with apoptosis, and pulmonary arterial hypertension. miR-223-5p has been involved in obesity, sepsis-induced inflammation (IL6 and TNFα), myocardial dysfunction and mortality in the literature. miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling and inflammation. In our study, 118 genes were associated with the 3 upregulated miRNAs and 601 genes were associated with the 3 downregulated miRNAs. GO enrichment analysis showed that upregulated miRNA associated genes were enriched in regulation of transcription and cell cycle. Downregulated miRNA associated genes were enriched in regulation of cell proliferation. Conclusions: A change in sodium intake affects miRNA expression, which could be one of the underlying mechanisms that high sodium intake promotes hypertension and CVD.
Introduction: Sodium reduction has been shown to reduce blood pressure (BP) and the incidence of cardiovascular disease (CVD), while the underlying molecular mechanisms are still not clear. Emerging evidence suggest that miRNAs play an important role in CVD. Hypothesis: We aim to test the hypothesis that a reduction in sodium intake could induce changes in miRNA expression in hypertensives and those miRNA changes would be associated with improved BP, inflammation and kidney function. Methods: A whole genome miRNA next generation sequencing was carried out in paired serum samples selected from 10 black male untreated hypertensive subjects in a randomized double-blind crossover trial (slow sodium vs placebo while on low-sodium diet). Mixed-effects linear regression model was used to assess the differential expression between sodium and placebo tablets. Differentially expressed miRNAs were analyzed for enrichment by DIANA-miRPath v3.0. Mixed-effect model was used to examine the associations between changes i...
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