A 3-year-old German Short-haired Pointer was examined because of extreme agitation, hyperactivity, and vomiting that began within 24 hours after ingestion of approximately 750 mg of pemoline, a CNS stimulant. On physical examination, the dog was agitated, tachycardic, hyper-responsive, pyrectic, disoriented, and had mydriasis. These signs were consistent with excessive stimulation of the CNS and sympathomimetic effects resulting from pemoline toxicosis. Serial blood and urine samples were obtained, and toxicologic analyses were performed. Extrapolation of the plasma pemoline concentration 32 hours after ingestion provided an estimated peak plasma concentration of 368 micrograms/ml, dramatically higher than a therapeutic concentration of 1.7 to 7.0 micrograms/ml reported for children. Several sedatives were administered intravenously to alleviate clinical signs and to allow administration of activated charcoal (PO) and fluids (IV). Clinical signs resolved approximately 72 hours after ingestion of pemoline.
Abstract Strukturen und Bindungen der Komplexe (I) und (II) sowie der aus Cu‐dihalogeniden und Theophyllin in siedendem Methanol synthetisierten Komplexe (III) werden anhand von IR‐spektroskopischen Vergleichen und magnetischen Eigenschaften diskutiert.
Abstract Cu(II) halide and primary amine complexes of kinetin (Kin) and 6-benzylaminopurine (6-BAP) of the type Cu(Kin)Cl2, Cu(Kin)Br2, Cu(6-BAP)Cl2, and Cu(Kin)2(CH3NH2)3 were synthesized. Low frequency IR absorptions of the halide adducts can be assigned to Cu-X stretches and are suggestive of a trans square-planar arrangement about the metal centre. The amine complex exhibits the loss of an aromatic IR N-H stretch, consistent with deprotonation of the purine ring and the formation of a metal complex. Room temperature magnetic susceptibilities are subnormal for mononuclear Cu(II) compounds. N(3)-N(9) bridging between copper centres is postulated by comparison with known metal ion structures of purines; the possibility of N(7)-N(9) bridging cannot however be disregarded.
Abstract Durch elektrolytische Reduktion der Phosphazene in Dimethylformamid‐, tert.‐Butylammoniumhalogenid‐ oder Perchloratlösung als Elektrolyten gelingt die Darstellung der Radikalanionen (I).
Abstract Theophyllin bildet bei der 2:1‐molaren Umsetzung mit hydratisierten Cu(II)‐, Zn(II)‐ und Cd(II)‐Salzen in 7.5 M Ammoniak oder wäßrigem Methylamin die meist als Hydrate isolierten, kristallinen Bis‐[theophyllinato]‐diammin‐Komplexe (I) in hohen Ausbb.
A 5-month-old 22-kg (48.4-lb) sexually intact male Collie was examined after ingesting a moxidectin-containing deworming medication. The dog was comatose and had respiratory arrest after progressively worsening lethargy, ataxia, and seizures. Exposure was confirmed by isolation of moxidectin from a biopsy specimen of adipose tissue, using liquid chromatography-mass spectroscopy methods. Treatment included use of intermittent positive-pressure ventilation, activated charcoal and cathartic administered enterally, nutrients administered via nasogastric tube, and intensive supportive care. The dog was weaned from a ventilator on day 6 after ingestion and was discharged on day 10. The dog was considered clinically normal during examination 24 days after ingestion. On the basis of the dog reported here and toxicologic data provided by the manufacturer of the deworming product, some Collies may have increased susceptibility to products containing high doses of moxidectin.
[Cu(C 8 H 11 N 2 )(C 6 H 6 NO)] cristallise dans Pbca avec affinement jusqu'a 0,032. L'atome Cu est coordine a deux ligands bidentes differents et a une geometrie plan carree
