Bang‐Le Zhang

Air Force Medical University

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Siyuan Zhou

Air Force Medical University

Qibing Mei

Southwest Medical University

Miao Liu

Renmin Hospital of Wuhan University

Meng‐Lei Huan

Air Force Medical University

Daozhou Liu

Air Force Medical University

Han Cui

Shandong Agricultural University

Shengyong Zhang

Ministry of Education of the People's Republic of China

Qifeng Ji

Air Force Medical University

Ying Cheng

Air Force Medical University

Yiyang Jia

Jilin University

Cooperative Institutions

Air Force Medical University

143

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

University of Chinese Academy of Sciences

Xijing Hospital

State Administration of Traditional Chinese Medicine of the People's Republic of China

Zhejiang University

Sun Yat-sen University

Soochow University

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Simultaneous quantitative determination of 9 active components in traditional Chinese medicinal preparation ShuangDan oral liquid by RP-HPLC coupled with photodiode array detection

Journal of Pharmaceutical and Biomedical Analysis (2011)

Hua Li Siwang Wang Bang‐Le Zhang Yanhua Xie Qian Yang

Paeoniflorin

Paeonol

Protocatechuic acid

Rosmarinic acid

10.1016/j.jpba.2011.07.016

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Citations (26)

Efficient iridium and rhodium-catalyzed asymmetric transfer hydrogenation using 9-amino(9-deoxy)cinchona alkaloids as chiral ligands

Applied Organometallic Chemistry (2006)

Wei He Peng Liu Bang‐Le Zhang Xiao Sun Sheng Yong Zhang

9-Amino (9-deoxy) cinchona alkaloids, derived from natural cinchona alkaloids, were applied in asymmetric transfer hydrogenation in both iridium and rhodium catalytic systems using i-propanol as the hydrogen source. A series of aromatic ketones was examined, and good to excellent conversions and enantioselectivities were observed. The best results were achieved using 9-amino(9-deoxy) epicinchonine 2a as the ligand and [Ir(COD)Cl]2 as the metal precursor, and for the isobutylphenone, the conversion and enantioselectivity were obtained in 90 and 97% e.e. respectively. Copyright © 2006 John Wiley & Sons, Ltd.

Transfer hydrogenation

Cinchona Alkaloids

Cinchona

Asymmetric hydrogenation

10.1002/aoc.1055

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Citations (33)

Construction of GSH-responsive polyethyleneimine-based delivery vector for effective gene transfection

Nanotechnology (2024)

Fang Kou Wang We Xiaohong Zhu Tian‐Yan Han Yajun Shi

Abstract The rise of gene therapy has solved many diseases that cannot be effectively treated by conventional methods. Gene vectors is very important to protect and deliver the therapeutic genes to the target site. Polyethyleneimine (PEI) modified with mannitol could enhance the gene transfection efficiency reported by our group previously. In order to further control and improve the effective gene release to action site, disulfide bonds were introduced into mannitol-modified PEI to construct new non-viral gene vectors PeiSM. The degrees of mannitol linking with disulfide bonds were screened. Among them, moderate mannitol-modified polyethyleneimine with disulfide bonds (M-PeiSM) showed the best transfection efficiency, and significantly enhanced long-term systemic transgene expression for 72 hours in vivo even at a single dose administration, and could promote caveolae-mediated uptake through up-regulating the phosphorylation of caveolin-1 and increase the loaded gene release from the nanocomplexes in high GSH intracellular environment. This functionalized gene delivery system can be used as an potential and safe non-viral nanovector for further gene therapy.

10.1088/1361-6528/ad6326

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Citations (1)

Preparation, Physicochemical Properties, and Transfection Activities of Tartaric Acid-Based Cationic Lipids as Effective Nonviral Gene Delivery Vectors

Biological and Pharmaceutical Bulletin (2016)

Ning Wan Yiyang Jia Yilin Hou Xi-Xi Ma Yongsheng He

In this work two novel cationic lipids using natural tartaric acid as linking backbone were synthesized. These cationic lipids were simply constructed by tartaric acid backbone using head group 6-aminocaproic acid and saturated hydrocarbon chains dodecanol (T-C12-AH) or hexadecanol (T-C16-AH). The physicochemical properties, gel electrophoresis, transfection activities, and cytotoxicity of cationic liposomes were tested. The optimum formulation for T-C12-AH and T-C16-AH was at cationic lipid/dioleoylphosphatidylethanolamine (DOPE) molar ratio of 1 : 0.5 and 1 : 2, respectively, and N/P charge molar ratio of 1 : 1 and 1 : 1, respectively. Under optimized conditions, T-C12-AH and T-C16-AH showed effective gene transfection capabilities, superior or comparable to that of commercially available transfecting reagent 3β-[N-(N′,N′-dimethylaminoethyl)carbamoyl]cholesterol (DC-Chol) and N-[2,3-dioleoyloxypropyl]-N,N,N-trimethylammonium chloride (DOTAP). The results demonstrated that the two novel tartaric acid-based cationic lipids exhibited low toxicity and efficient transfection performance, offering an excellent prospect as nonviral vectors for gene delivery.

Cationic polymerization

Tartaric acid

Dodecanol

10.1248/bpb.b16-00007

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Citations (8)

LC Tissue Distribution Study of Paeonol in Rats after Oral Administration

Chromatographia (2011)

Hua Li Siwang Wang Qian Yang Yanhua Xie Wei Cao

Paeonol

Protein precipitation

Paeonia suffruticosa

Quantitative Analysis

10.1007/s10337-010-1908-z

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Citations (10)

Response to the Potential and Challenges of Autophagy in the Treatment of Liver Fibrosis

Liver International (2025)

Li‐Shuang Hou Bang‐Le Zhang

We thank Dr. Jia Chen and Qichang Xing for their interest in the article published in Liver International about the research on targeted delivery system HCQ@ROL-LNPs loaded with hydroxychloroquine (HCQ) for the treatment of liver fibrosis [1]. HCQ@ROL-LNPs can be uptaken specifically by activated hepatic stellate cells (aHSCs) and inhibit the autophagy of aHSCs to improve liver fibrosis. As mentioned by the authors [2], autophagy of different types of liver cells has different effects on liver fibrosis [3]. HCQ@ROL-LNPs can reduce the activation and extracellular matrix deposition by targeting aHSCs, and at the same time avoid the influence on other types of liver cells, which is well situated to treat liver fibrosis. It is very necessary to verify the dose–response relationship of drugs before they are transformed into clinical applications [4]. This paper is a delivery system study, in which the dose of HCQ was on the basis of previous screening experiments [5]. The dose–response relationship and the therapeutic effect after long-term administration will continue to be studied in the follow-up experiment. The previous research was mainly to validate the efficacy in mice, and it is also very necessary to verify the therapeutic effect in other species before entering clinical trials. The constructed HCQ@ROL-LNPs provides a new targeted strategy by using autophagy inhibition of aHSCs for the treatment of liver fibrosis. Before it is used in clinic, it is still necessary to conduct extensive research to verify its potential efficacy and therapeutic safety, which will provide the evidence for the clinical use of antiliver fibrosis drugs in the future. The authors declare no conflicts of interest. Data sharing is not applicable to this article as no data sets were generated or analysed during the current study.

10.1111/liv.16238

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Citations (0)

Maintenance of mitochondrial homeostasis for Alzheimer's disease: Strategies and challenges

Redox Biology (2023)

Ying Han Daozhou Liu Ying Cheng Qifeng Ji Miao Liu

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and its early onset is closely related to mitochondrial energy metabolism. The brain is only 2% of body weight, but consumes 20% of total energy needs. Mitochondria are responsible for providing energy in cells, and maintaining their homeostasis ensures an adequate supply of energy to the brain. Mitochondrial homeostasis is constituted by mitochondrial quantity and quality control, which is dynamically regulated by mitochondrial energy metabolism, mitochondrial dynamics and mitochondrial quality control. Impaired energy metabolism of brain cells occurs early in AD, and maintaining mitochondrial homeostasis is a promising therapeutic target in the future. We summarized the mechanism of mitochondrial homeostasis in AD, its influence on the pathogenesis of early AD, strategies for maintaining mitochondrial homeostasis, and mitochondrial targeting strategies. This review concludes with the authors' opinions on future research and development for mitochondrial homeostasis of early AD.

Homeostasis

Energy homeostasis

DNAJA3

10.1016/j.redox.2023.102734

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Citations (20)

Construction of the pulmonary bio-adhesive delivery system of nintedanib nanocrystalline for effective treatment of pulmonary fibrosis

International Journal of Pharmaceutics (2024)

Chong-Xiao Yun Meng‐Lei Huan Xiaohong Zhu Yu-Hang Wan Junbo Zou

Nintedanib

10.1016/j.ijpharm.2024.124302

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Citations (0)

Bone metastasis target redox-responsive micell for the treatment of lung cancer bone metastasis and anti-bone resorption

Artificial Cells Nanomedicine and Biotechnology (2018)

Wei-Liang Ye Yipu Zhao Ying Cheng Dao-Zhou Liu Han Cui

In order to inhibit the growth of lung cancer bone metastasis and reduce the bone resorption at bone metastasis sites, a bone metastasis target micelle DOX@DBMs-ALN was prepared. The size and the zeta potential of DOX@DBNs-ALN were about 60 nm and −15 mV, respectively. DOX@DBMs-ALN exhibited high binding affinity with hydroxyapatite and released DOX in redox-responsive manner. DOX@DBMs-ALN was effectively up taken by A549 cells and delivered DOX to the nucleus of A549 cells, which resulted in strong cytotoxicity on A549 cells. The in vivo experimental results indicated that DOX@DBMs-ALN specifically delivered DOX to bone metastasis site and obviously prolonged the retention time of DOX in bone metastasis site. Moreover, DOX@DBMs-ALN not only significantly inhibited the growth of bone metastasis tumour but also obviously reduced the bone resorption at bone metastasis sites without causing marked systemic toxicity. Thus, DOX@DBMs-ALN has great potential in the treatment of lung cancer bone metastasis.

10.1080/21691401.2018.1426007

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Citations (11)

Design and evaluation of novel pH-sensitive ureido-conjugated chitosan/TPP nanoparticles targeted to Helicobacter pylori

Biomaterials (2016)

Ziwei Jing Yiyang Jia Ning Wan Min Luo Meng‐Lei Huan

10.1016/j.biomaterials.2016.01.045

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Citations (93)