С. А. Гаврилова

Research Field

Human physiology

Homeostasis

10.1134/s0362119720050126

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[Dynamic of myocarditis development in rats after injection of cardiac myosine combined with IFA].

PubMed (2012)

Morozova Mp С. А. Гаврилова Л. В. Земцова Pogodina Ls Postnikov Ab

Myocarditis development was investigated after immunization rats with single subcutaneous injection of cardiac myosin (800 microg/kg) with incomplete Freund's adjuvant (IFA) (M + IFA group). Control group received equal volume of IFA alone or nothing (intact group). On days 4, 14, and 21 after injection, light and electron microscopy of heart sections, morphometric analysis, estimation of proinflammatory cytokines (IL-1p, IL-6, VEGF, TNFa and iNOS) expression were used to evaluate inflammatory response in myocardium. In addition, we estimated cardiac myosin antibody levels in blood serum and nitrite and nitrate levels in blood serum. Our data showed that immunization with cardiac myosin combined with IFA led to inflammatory response in the rat myocardium. Acute inflammation (i.e. lymphocyte infiltration of myocardium and increase of proinflammatory cytokines level) in M + IFA group occurred on 21 days after immunization.

Proinflammatory cytokine

Infiltration (HVAC)

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Protective effect of hypoxic and ischemic preconditioning in rat brain local ischemia

Doklady Biological Sciences (2007)

N. S. Samoilenkova С. А. Гаврилова В. Б. Кошелев

Ischemic Preconditioning

Hypoxia

10.1134/s0012496607030039

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[THE ROLE OF INFLAMMATION IN THE DEVELOPMENT OF PROLIFERATIVE VITREORETINOPATHY].

PubMed (2015)

Tikhonovich Mv Iojleva Ej С. А. Гаврилова

This paper focuses on the risk factors of primay and secondary proliferative vitreoretinopathy, modern views of pathophysiology of this disease, and the role of inflammation in its development. Special attention is given to the involvement of pigment epithelial cells, macrophages, hyalocytes, gliocytes, supporting fibers (Muller's cells), mediators of inflammation, such as cytokines, chemokines, and growth factors, with reference to their interaction in the processes of proliferation and development of retinal membranes.

Proliferative Vitreoretinopathy

Pathophysiology

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ВЛИЯНИЕ ВОСПАЛЕНИЯ НА ПАРАМЕТРЫ ВАРИАБЕЛЬНОСТИ РИТМА СЕРДЦА У КРЫС С ИНФАРКТОМ МИОКАРДА И АУТОИММУННЫМ МИОКАРДИТОМ

М.П. Морозова А. М. Горбачева А.Б. Бердалин Е.В. Лукошкова С. А. Гаврилова

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Защита мозга и сердца от ишемических повреждений с помощью пролин-содержащего пептида семакс,

С. А. Гаврилова Anna V. Golubeva Э.Р. Басырова Т.В. Липина Е.С. Фоминых

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Dynamics of heart rate variability in rats with streptozotocin-induced diabetes

DOAJ (DOAJ: Directory of Open Access Journals) (2019)

M. P. Morozova С. А. Гаврилова E. V. Ivanov А. М. Горбачева Ekaterina M. Rzhavina

10.14341/dm9499

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P.5.066 Neuroprotective properties of the novelnootropic dipeptide noopept (GVS-111) on the model of severe brain ischemia

European Neuropsychopharmacology (2005)

К. С. Ус С. А. Гаврилова В. Б. Кошелев

10.1016/s0924-977x(05)80468-7

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THE INFLUENCE OF THE DIHYDROQUERCETIN LIPOSOMAL FORM ON HEART FUNCTION IN THE BLEOMYCIN-INDUCED RAT MODEL OF PULMONARY FIBROSIS

Neuroscience for Medicine and Psychology (2024)

Marina Akhmetshina Albina Gizatulina Alexander Gorohov Aleksei Erdiakov E. V. Ivanov

10.29003/m3834.sudak.ns2024-20/50-51

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Дифференциация кератиноцитов и заживление раны в стрептозотоциновой модели сахарного диабета крысы с выраженной гипергликемией

Сахарный диабет (2020)

Евгений Викторович Иванов Мария Павловна Морозова Екатерина Михайловна Ржавина А. М. Горбачева С. А. Гаврилова

BACKGROUND: Diabetes mellitus leads to disruption of the skin repair processes, but the leading mechanisms of this pathology have not yet been identified. In this regard, in our work, we decided to check how hyperglycaemia affects the process of keratinocyte phenotype changes during wound healing. AIMS: To study the effect of hyperglycaemia on wound healing and differentiation of keratinocytes in a rat streptozotocin-induced diabetes model. MATERIALS AND METHODS: Diabetes mellitus was induced in rats by using streptozotocin, 65 mg / kg, intraperitoneally, once. The wound was applied in the supra-scapular region on the 42nd day, after which (after 8, 16, and 24 days) the repair process was evaluated using histological methods. Immunohistochemistry was used to evaluate the expression of cytokeratin-10 and cytokeratin-17. RESULTS: In rats with diabetes mellitus, wound healing slowed down in the later stages, compared with the control group. In general, wound healing was accompanied by an increase in the expression of cytokeratin-10 in its region compared with intact skin, and contractile keratinocytes activation was disrupted in diabetic rat wounds. CONCLUSIONS: Hyperglycaemia slightly slows wound healing in rats and impairs contractile keratinocytes activation.

10.14341/dm10071-9492

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С. А. Гаврилова

Papers

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H-Index

i-10 index

Papers

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H-Index

i-10 index