Asaki Soeda

Kobe Medical Center

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Sojun Kanamaru

Kobe City Nishi-Kobe Medical Center

Shusuke Akamatsu

Nagoya University

Hideo Takeuchi

Osaka City University

Keita Fujikawa

Japan Community Healthcare Organization

Jun Takenawa

Japanese Red Cross Society Wakayama Medical Center

Noriyuki Ito

Japanese Red Cross Society Wakayama Medical Center

Hiroya Oka

Nagoya University

M Nonomura

Kyoto Katsura Hospital

Shigeki Fukuzawa

Shimada Municipal Hospital

J Takenawa

Kobe Medical Center

Cooperative Institutions

Kyoto University

Kobe City Medical Center General Hospital

Kyoto University Hospital

Kobe Medical Center

Kurashiki Central Hospital

Kansai Medical University

National Hospital Organization

Shizuoka City Hospital

Osaka University

Toyooka Hospital

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Primary large cell neuroendocrine carcinoma of the urinary bladder

International Journal of Urology (2008)

Shusuke Akamatsu Sojun Kanamaru Misa Ishihara Takeshi Sano Asaki Soeda

Abstract: Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is rare. It is a type of neuroendocrine carcinoma morphologically distinct from small cell carcinoma. We report here a case of primary LCNEC of the urinary bladder. We observed a very large invasive tumor, which was not able to be detected three months previously by cystoscopy or computed tomography. The tumor cells morphologically and immunohistochemically resembled that of pulmonary LCNEC. With prompt cystoprostatectomy and chemotherapy, the patient is free of disease 16 months after diagnosis. Although LCNEC is usually very aggressive, it may be controlled by early diagnosis and treatment.

Cystoprostatectomy

Neuroendocrine carcinoma

10.1111/j.1442-2042.2008.02168.x

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Citations (35)

[Multiple primary cancers limited to the urological field].

PubMed (2001)

Hiroya Oka Susumu Kobayashi T Kobayashi Y Shugino Yuuki Matsui

We analyzed the clinical features of multiple primary cancers arising from the urogenital organs. Between January 1980 and December 1999, 300 patients with renal cell carcinoma (RCC), 661 patients with urothelial carcinoma (bladder cancer and renal pelvic-ureteral cancer) (TCC) and 391 patients with prostate cancer (PC) were treated at our hospital. Of these patients, 20 patients had double genitourinary cancers. The double cancers consisted of RCC and TCC in 1 case, RCC and PC in 6 cases, and TCC and PC in 13 cases. Seven cases had synchronous tumors. The average interval in the metachronous cases was 68 (range: 12-209) months. The age at diagnosis of the second cancer was 68-94 (mean: 77.6) years old. The follow-up period ranged from 4-168 (mean: 38) months; Six patients are alive with no evidence of disease and 6 patients died of cancer. Even when limited to the urological section, the frequency of multiple primary cancers is increasing.

Kidney cancer

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Relationship between type of suture and anastomotic stricture after radical prostatectomy

Takeshi Sano Ryo Iguchi Asaki Soeda Sojun Kanamaru Noriyuki Ito

We evaluated the relationship between the type of suture and occurrence of anastomotic stricture after radical retropubic prostatectomy (RRP). From April 2005 to February 2008, 48 RRP were performed. In the former 24 cases, 2-0 absorbable braided sutures were used (group A), and in the latter 24 cases, 3-0 absorbable monofilament sutures were used (group B) in the vesicourethral anastomosis. In group B, operation time was longer, blood loss was less and tumor stage was lower. While five patients in group A developed an anastomotic stricture, but no one in group B developed a stricture. Univariate analysis of the two groups revealed that only the type of suture and age were significant parameters for the anastomotic stricture.

Radical retropubic prostatectomy

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A case of female large urethral diverticulum treated by electrofulguration

International Journal of Urology (1999)

Keita Fujikawa Yoshiyuki Matsui Shigeki Fukuzawa Asaki Soeda Hideo Takeuchi

Abstract Female urethral diverticulum is not an uncommon disease. We report a case of female urethral diverticulum which caused severe urethral pain, but for which the diagnosis had not been obtained at many hospitals for many years. Transurethral electrocauterization of the diverticulum was very effective in this case.

Urethral Diverticulum

Urethral Diseases

Female urethra

10.1046/j.1442-2042.1999.00122.x

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Citations (3)

Immune thrombocytopenia during interferon-alfa therapy for renal cell carcinoma.

Hinyokika Kiyo (2006)

Shusuke Akamatsu Akira Asazuma Sojun Kanamaru Jun Takenawa Asaki Soeda

Immune thrombocytopenia is a rare complication of interferon-alfa (IFN-alpha). A patient with renal cell carcinoma developed severe thrombocytopenia during therapy with purified IFN-alpha. The patient's exposure to IFN, exclusion of other causes, and bone marrow biopsy were consistent with drug-induced immune thrombocytopenia. Cessation of IFN and corticosteroid administration resulted in the prompt recovery of platelets. The patient was re-challenged with recombinant IFN-alpha-2b under careful observation; there was no occurrence of severe thrombocytopenia. It was suggested that the difference of the subtypes composing IFN-alpha resulted in the lack of cross reactivity.

Interferon alfa

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Citations (7)

Nephrotoxicity of cis-diamminedichloroplatinum (II) (cis-platinum) and the additive effect of antibiotics: Morphological and functional observation in rats

Toxicology and Applied Pharmacology (1981)

J Kawamura Asaki Soeda Osamu Yoshida

Nephrotoxicity

10.1016/0041-008x(81)90100-9

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Citations (17)

[Multi-institute survey on actual conditions of urologic management for severe bladder dysfunction after hysterectomy].

Koji Yoshimura Toshiyuki Kamoto Takuya Okada Mutsushi Kawakita Hiroki Ikeda

We conducted a multi-institute survey on the conditions related to urologic management of severe voiding dysfunction after hysterectomy for uterine cancer with or without postoperative irradiation. Our first study population was a group of adult female patients currently managed by urologists, using clean intermittent catheterization (CIC). Of the 287 patients in this group, 99 (34%) had suffered from uterine cancer. Of these patients, 94 underwent hysterectomy for this disease; 44 and 30 were treated with or without postoperative radiation, respectively, while postoperative irradiation status was unknown for 20. Median follow-up after surgery was 21 (0.2-52) years and median interval from operation to the introduction of CIC was 4.0 (0-49) years. CIC tended to be introduced later for patients with postoperative radiation than those without it. Seventy-four patients, who required invasive urologic interventions other than CIC for voiding dysfunction after hysterectomy, are the second study population. Most of these (82%) had received postoperative irradiation. Continuous Foley catheter placement was the most frequent procedure. Long-term follow-up and urologic management for voiding dysfunction is required for patients undergoing hysterectomy.

Foley

Foley catheter

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Ectopic adrenocorticotropic hormone syndrome in a case of small cell carcinoma of the bladder manifesting as severe muscle weakness

Urology (2006)

Shusuke Akamatsu J Takenawa Sojun Kanamaru Asaki Soeda

Muscle weakness

10.1016/j.urology.2006.08.1087

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Citations (6)

[Primary paraganglioma of the urinary bladder with high serum CA19-9 level: a case report].

PubMed (2000)

Yoshiharu Nakayama Akira Asazuma T Shirahase Asaki Soeda K. Hashimoto

A case of primary paraganglioma of the urinary bladder with a high serum CA19-9 level is reported. A 44-year-old woman visited our hospital with the chief complaint of lower abdominal pain. Magnetic resonance imaging (MRI) examination incidentally revealed a cystic bladder tumor. Cystoscopy disclosed a broad-based non-papillary tumor on the posterior wall of the urinary bladder. With the diagnosis of a bladder submucosal cystic tumor transurethral needle puncture and biopsy were performed. The solution sampled with puncture was bloody. The patient suddenly complained of headache and blood pressure was elevated to 215/120 mmHg when we held the tumor with a cold cup biopsy forceps. Catecholamine levels of the solution in the tumor were abnormally elevated. The serum CA19-9 level was also raised. Ten days later, she underwent partial cystectomy. Histological findings of the removed specimen showed primary paraganglioma of the urinary bladder. The serum CA19-9 level decreased to normal limits on the 28th postoperative day. Our experience suggests that the level of serum CA19-9 may serve as a useful index for observing the clinical course of a patient with this disease.

Bloody

CA19-9

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[A case of unilateral and metachronous occurrence of renal tubulopapillary adenoma and renal cell carcinoma].

PubMed (2000)

Yoshiyuki Matsui K Miura T Kobayashi Keita Fujikawa S Fukuzawa

A 50-year-old male underwent a nephron-sparing surgery for a small renal incidentaloma, which was atypical for renal cell carcinoma in diagnostic images. The tumor was pathologically diagnosed as renal tubulopapillary adenoma. Three years later, another tumor was pointed out in the ipsilateral kidney, and he underwent a radical nephrectomy. The latter was diagnosed as clear cell carcinoma. We report this very rare case of unilateral and metachronous occurrence of renal tubulopapillary adenoma and renal cell carcinoma.

Renal tumor

Clear cell carcinoma

Kidney cancer

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