Paola Torre

Centro Medico Nacional Siglo XXI

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Rita Moretti

University of Trieste

Rodolfo M. Antonello

University of Trieste

Giuseppe Cazzato

Istituto Nazionale di Fisica Nucleare, Sezione di Firenze

Antonio Bava

University of Trieste

Tatiana Cattaruzza

University of Trieste

Sergio Sánchez‐García

Mexican Social Security Institute

Maja Ukmar

Azienda Sanitaria Universitaria Integrata di Trieste

Rita Moretti

University of Trieste

José Darío Martínez‐Ezquerro

Mexican Social Security Institute

L. Capus

University of Padua

Cooperative Institutions

Mexican Social Security Institute

Centro Medico Nacional Siglo XXI

University of Trieste

Universidad Nacional Autónoma de México

Hospital de Especialidades

Ospedale di Cattinara

Instituto Nacional de Pediatria

Istituti di Ricovero e Cura a Carattere Scientifico

Instituto Politécnico Nacional

Baylor College of Medicine

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Review for "Influence of Cortisol Awakening Response on Telomere length: Trends for males and females"

Paola Torre

10.1111/ejn.14996/v1/review2

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Citations (0)

Cognitive changes following subthalamic nucleus stimulation in Patients with Parkinson disease.

Paola Torre L. Capus Manuela Gioulis Sandro Zambito Marsala Antonio Bava

Subthalamic Nucleus

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Vitamin B₁₂ defect: what does it mean to cognition?

European Journal of Neurology (2001)

Rita Moretti Paola Torre Rodolfo M. Antonello Giuseppe Cazzato Antonio Bava

10.1046/j.1468-1331.2001.00294.x

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Citations (3)

[Role of the cerebellum in the control of distal motor activities in patients with akinetic-rigid Parkinson disease].

PubMed (2005)

Rita Moretti Paola Torre Rodolfo M. Antonello Maja Ukmar Giuseppe Cazzato

Using f-MRI, we have studied the changes induced by the performance of a complex sequential motor task in the cortical areas of nine akinetic PD patients and compared to that of healthy volunteers. Compared with normal subjects, PD patients showed a reduction of activation of motor and SMA areas, an increase of activation of parietal areas and a bilateral activation of cerebellar hemispheres, which are likely to participate in the attempt to recruit parallel motor circuits in order to overcome the striatocortical defective loop.

Supplementary motor area

Motor Control

Motor Learning

Motor impairment

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Citations (1)

日本語目次

Dementia and Geriatric Cognitive Disorders (2005)

Andrew K. Chen Jill Shapira Bruce L. Miller Michiaki Ootani Isao Nara

10.1159/000089008

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Insomnia Impairs Both the Pro-BDNF and the BDNF Levels Similarly to Older Adults with Cognitive Decline: An Exploratory Study

International Journal of Molecular Sciences (2023)

Sergio Sánchez‐García Karla Moreno‐Tamayo Ricardo Ramírez‐Aldana Carmen García‐Peña Raúl Hernán Medina-Campos

Sleep disorders, including insomnia, are common during aging, and these conditions have been associated with cognitive decline in older adults. Moreover, during the aging process, neurotransmitters, neurohormones, and neurotrophins decrease significantly, leading to the impairment of cognitive functions. In this sense, BDNF, the most abundant neurotrophic factor in the human brain, has been suggested as a potential target for the prevention and improvement of cognitive decline during aging; however, the current evidence demonstrates that the exogenous administration of BDNF does not improve cognitive function. Hence, in the present study, we quantified pro-BDNF (inactive) and BDNF (active) concentrations in serum samples derived from older individuals with insomnia and/or cognitive decline. We used linear regression to analyze whether clinical or sociodemographic variables impacted the levels of BNDF concentration. We observed that insomnia, rather than cognitive decline, is significantly associated with BDNF concentration, and these effects are independent of other variables. To our knowledge, this is the first study that points to the impact of insomnia on improving the levels of BDNF during aging and suggests that opportune treatment of insomnia may be more beneficial to prevent cognitive decline during aging.

Cognitive Decline

Neurohormones

10.3390/ijms24087387

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Citations (9)

Frontal Lobe Dementia and Subcortical Vascular Dementia: A Neuropsychological Comparison

Psychological Reports (2005)

Rita Moretti Paola Torre Rodolfo M. Antonello Tatiana Cattaruzza Giuseppe Cazzato

We compared the performance of 40 patients with frontal lobe dementia to that of 40 patients with subcortical vascular dementia (80 patients including, 46 men and 34 women) in a set of tasks assessing attentional, executive, and behavioural tasks. The frontal lobe dementia represents an important cause for degenerative disruption and is increasingly recognised as an important form (up to 25%) of degenerative dementia among individuals of late-middle-age. The main involvement is the frontal-subcortical pathway, which is the final target of impairment even in subcortical vascular dementia. A wider involvement of the cortical (decisional) layers in frontal dementia, in contrast with the prominent and widespread involvement of the subcortical pathways (refinement and corrections programs) creates the different profiles of the two groups. Frontal patients have more difficulties in abstract reasoning, focusing attention, and implementing strategies to solve problems. They exhibit more profound behavioural alterations in personality and social conduct and show only moderate depression, and a total lack of insight concerning their clinical condition. In contrast, the patients with subcortical vascular dementia have poor general cognitive functions, high insight, and important depression and apathy as the principal and most salient characteristic of their behavioral conduct.

Apathy

Frontal lobe

Vascular dementia

Depression

10.2466/pr0.96.1.141-151

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Citations (24)

Double-Blind, Placebo-Controlled, Randomized, Crossover Trial of High-Dose Methylprednisolone in Patients with Chronic Progressive Form of Multiple Sclerosis

European Neurology (1995)

Giuseppe Cazzato Tiziana Mesiano Rodolfo M. Antonello Fabrizio Monti Nicola Carraro

A double-blind, placebo-controlled, randomized crossover trial of high-dose methylprednisolone (MP) was performed in 35 patients with a primarily chronic progressive form of multiple sclerosis as defined clinically according to Poser's criteria. At time 0 of every course of treatment (1 g MP administered i.v. daily for 5 days followed by oral prednisone tapering over 4 days, or placebo) and at 10, 30 and 90 days thereafter, each patient underwent psychometric tests and was clinically tested according to Kurtzke's Expanded Disability Status Scale (EDSS). The disability pattern of most patients who were treated with placebo either worsened or did not change. A statistically significant improvement (p < 0.001) of EDSS in MP-treated patients was recorded. The improvement mainly concerned the pyramidal, cerebellar and sensitive disorders; it was already evident at the first clinical follow-up and lasted for 3 months from the beginning of the treatment. No frequent and/or important side effects were detected throughout the trial.

Crossover study

10.1159/000117127

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Citations (48)

Taste aversion memory reconsolidation is independent of its retrieval

Neurobiology of Learning and Memory (2012)

Carlos J. Rodríguez‐Ortiz Israela Balderas Paola Torre Federico Bermúdez‐Rattoni

Taste aversion

Anisomycin

Retrograde amnesia

10.1016/j.nlm.2012.08.002

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