Givalda Mendonça da Cruz Macieira

Universidade Federal de Sergipe

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Mônica Thaís Ferreira Nascimento

Universidade Federal de Sergipe

Alfredo Dias de Oliveira‐Filho

Universidade Federal de Sergipe

Tâmara Natasha Gonzaga de Andrade Santos

Universidade Federal de Sergipe

Fernando de Castro Araújo-Neto

Universidade Federal de Sergipe

Alessandra Rezende Mesquita

Universidade Federal de Sergipe

Divaldo Pereira de Lyra

Universidade Federal de Sergipe

Giselle de Carvalho Brito

Universidade Federal de Sergipe

Sabrina Joany Felizardo Neves

Universidade Federal de Alagoas

Fábio Jorge Ramalho de Amorim

Universidade Federal de Sergipe

Ana Amélia Moreira Lira

Universidade Federal de Sergipe

Cooperative Institutions

Universidade Federal de Sergipe

Instituto de Ciências Farmacêuticas

Universidade Federal de Alagoas

Universidade Federal do Espírito Santo

Universidade Federal de Pernambuco

Universidade Estadual de Ciências da Saúde de Alagoas

Universidade de São Paulo

Weatherford College

Universidade Estadual Paulista (Unesp)

Centro Universitário da Cidade

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Microemulsions formed by PPG-5-CETETH-20 at low concentrations for transdermal delivery of nifedipine: Structural and in vitro study

Colloids and Surfaces B Biointerfaces (2022)

Guilherme Rodolfo Souza de Araújo Givalda Mendonça da Cruz Macieira Dayane Xavier de Oliveira Saulo Santos Matos Quesia Nery dos Santos

Microemulsion

Penetration (warfare)

Lipophilicity

10.1016/j.colsurfb.2022.112474

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Citations (11)

CONTENT VALIDATION OF DRUG PROBLEM-ORIENTED CLINICAL RECORD.

Research in Social and Administrative Pharmacy (2025)

Tâmara Natasha Gonzaga de Andrade Santos Givalda Mendonça da Cruz Macieira Kérilin Stancine Santos Rocha Mônica Thaís Ferreira Nascimento Fernando de Castro Araújo-Neto

10.1016/j.sapharm.2025.01.009

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Prevalence of clinically manifested drug interactions in hospitalized patients: A systematic review and meta-analysis

PLoS ONE (2020)

Tâmara Natasha Gonzaga de Andrade Santos Givalda Mendonça da Cruz Macieira Bárbara Manuella Cardoso Sodré Alves Thelma Onozato Geovanna Cunha Cardoso

Aims This review aims to determine the prevalence of clinically manifested drug-drug interactions (DDIs) in hospitalized patients. Methods PubMed, Scopus, Embase, Web of Science, and Lilacs databases were used to identify articles published before June 2019 that met specific inclusion criteria. The search strategy was developed using both controlled and uncontrolled vocabulary related to the following domains: "drug interactions," "clinically relevant," and "hospital." In this review, we discuss original observational studies that detected DDIs in the hospital setting, studies that provided enough data to allow us to calculate the prevalence of clinically manifested DDIs, and studies that described the drugs prescribed or provided DDI adverse reaction reports, published in either English, Portuguese, or Spanish. Results From the initial 5,999 articles identified, 10 met the inclusion criteria. The pooled prevalence of clinically manifested DDIs was 9.2% (CI 95% 4.0–19.7). The mean number of medications per patient reported in six studies ranged from 4.0 to 9.0, with an overall average of 5.47 ± 1.77 drugs per patient. The quality of the included studies was moderate. The main methods used to identify clinically manifested DDIs were evaluating medical records and ward visits (n = 7). Micromedex® (27.7%) and Lexi-Comp® (27.7%) online reference databases were commonly used to detect DDIs and none of the studies evaluated used more than one database for this purpose. Conclusions This systematic review showed that, despite the significant prevalence of potential DDIs reported in the literature, less than one in ten patients were exposed to a clinically manifested drug interaction. The use of causality tools to identify clinically manifested DDIs as well as clinical adoption of DDI lists based on actual adverse outcomes that can be identified through the implementation of real DDI notification systems is recommended to reduce the incidence of alert fatigue, enhance decision-making for DDI prevention or resolution, and, consequently, contribute to patient safety.

10.1371/journal.pone.0235353

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Citations (43)

USE OF A DRUG-RELATED PROBLEM ORIENTED MEDICAL RECORD IN THE MEDICATION REVIEW OF CRITICALLY ILL PATIENTS – RANDOMIZED CLINICAL TRIAL

Research in Social and Administrative Pharmacy (2025)

Tâmara Natasha Gonzaga de Andrade Santos Givalda Mendonça da Cruz Macieira Rafaella de Oliveira Santos Silva Giselle de Carvalho Brito Sabrina Joany Felizardo Neves

Drug trial

10.1016/j.sapharm.2025.01.010

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