Shima Nafarzadeh

Babol University of Medical Sciences

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Ali Bijani

Babol University of Medical Sciences

Maryam Seyedmajidi

Babol University of Medical Sciences

Mohammad Moshref

Shahid Beheshti University of Medical Sciences

Sina Jafari

Jazan University

Hamid Reza Nouri

Babol University of Medical Sciences

Ebrahim Zabihi

Babol University of Medical Sciences

Oveis Khakbaz

Babol University of Medical Sciences

Fatemeh Mashhadi Abbas

Shahid Beheshti University of Medical Sciences

Zohreh Mohammad Taheri

University of Saskatchewan

Marjan Kiani

Babol University of Medical Sciences

Cooperative Institutions

Babol University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Tehran University of Medical Sciences

Mazandaran University of Medical Sciences

University of Tehran

Iran University of Medical Sciences

Imam Khomeini Hospital

Marymount University

Semnan University of Medical Sciences

Shahid Beheshti University

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SALIVA LEVELS OF IL-4 AND IFN γ IN PATIENTS WITH ORAL LICHEN PLANUS

Res Dent Sci (2013)

Shima Nafarzadeh Amrollah Mostafazadeh Ali Bijani Mohammad Ali Seddigh

Oral Lichen Planus

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Extramedullary plasmacytoma of the gingiva.

PubMed (2007)

Mohammad Moshref Fatemeh Mashhadi-Abbass Soudabeh Sargolzaei Shima Nafarzadeh

Extramedullary plasmacytoma is defined as neoplastic proliferation of plasma cells in soft tissue. It accounts for up to 3% of all plasma cell tumors. Approximately, 90% of extramedullary plasmacytomas are found in the head and neck region commonly affecting the nasal cavity, paranasal sinuses, tonsillar fossa, and oral cavity. Radiotherapy is the common modality of treatment with or without adjuvant chemotherapy. We report a case of extramedullary plasmacytoma of the gingiva.

Extramedullary plasmacytoma

Plasma cell neoplasm

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Relation between pulpal neuropeptides and dental caries.

PubMed (2010)

Ali Kangarlou Haghighi Shima Nafarzadeh Yazdan Shantiaee Mandana Naseri Zohreh Ahangari

Dental pulp has neural fibers that produce neuropeptides like Substance P (SP) and calcitonin gene-related peptide (CGRP). The inflammation of dental pulp can lead to an increase amount of SP and CGRP release, especially in symptomatic irreversible pulpitis. Therefore, it can be assumed that neuropeptides have some role in the progression of inflammation of the dental pulp. The aim of this study was to determine the relation between the presence and concentration of neuropeptides in dental pulps of carious teeth caries.For this purpose, pulpal tissues were collected from 40 teeth (20 carious and 20 intact). Pulpal samples were cultured for 72 hours. ELISA reader was used for the detection of SP and CGRP in supernatant fluids. Statistical analysis was made by Mann-Whitney U and Chi square tests.SP and CGRP were present in 65% and 20% of inflamed pulpal samples, respectively and 40% and 5% of normal pulpal samples, respectively. Level of SP was significantly higher in inflamed pulp samples compared to intact pulps; however, there was no statistical difference when the other groups and neuropeptides were compared. The mean concentration of SP in normal pulps was 3.4 times greater than that of CGRP; interestingly in inflamed pulps the concentration of SP was 22.3 times greater than CGRP.We can conclude that in inflamed dental pulps, the concentration of SP is higher than CGRP. It can be hypothesized that CGRP has less effect on the inflammatory changes of dental pulps.

Pulpitis

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Evaluation of mean AgNors in Squamous Cell Carcinomas and Verrucous Carcinomas of oral mucosa

Shahid Beheshti University Dental Journal (2007)

Soudabeh Sargolzaei Ahmad Nezhad Masoumeh Shima Nafarzadeh Mohammad Moshref

Background and Aim: Squamous cell carcinoma (SCC) of oral mucosa is the most prevalent malignant tumor among oral cancers with 95 % incidence. Verrucous Carcinoma of oral mucosa is a unique and well differentiated form of SCC which is diagnosed with some difficulty from SCC specially when SCC shows warty appearance and/or, shows high differentiation in histopathologic view. In addition when verrucous carcinoma shows higher displasia, it must be differentiated from early invasive SCC. So, when verrucous carcinoma is diagnosed before changing to SCC, unnecessary treatments can be avoided. The aim of this study was to evaluate the mean number of Argirophilic nuclear organized regions (mAgNor) in SCC and Verrucous carcinoma for differential diagnosis between them. Methods & Materials: Twenty formalin fixed parrafin embeded blocks including ten SCC and ten Verrucous, were analyzed for AgNor parameters. AgNOR expression was measured by microphotometry by silver stain. T and Mann – whitney U tests were used to compare the data. Results : mAgNor in SCC patients was 2.80±0.48 comparing with 1.95±0.28 in Verrucous carcinoma patients (P Less than 0.001). Conclusion : Since the mAgNor in SCC was statistically more than the mAgNor in Verrucous carcinoma, so, the AgNor staining technique can be applied for early diagnosis of Verrucous carcinoma from well differentiated SCC.

Verrucous carcinoma

Oral mucosa

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Cytomorphometric Analysis of Buccal Exfoliated Cells in Patients With Iron Deficiency Anemia

ACTA MEDICA IRANICA (2020)

Mahdieh Rajabi‐Moghaddam Hamid Abbaszadeh Maryam Mosaffa Hemmat Gholinia Shima Nafarzadeh

Iron deficiency anemia can cause histopathologic alterations in the oral mucosa. Exfoliative cytology is a cheaper and less aggressive method for early diagnosis. The aim of this study was to compare the cytological and cytomorphometric characteristics of buccal exfoliated cells of iron deficiency anemic patients with those of healthy controls. This case-control study compared a group of 40 patients with iron deficiency anemia (IDA) with an age- and gender-matched control group (C) of 40 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytological analyses. Cellular clumping, cytoplasmic diameter (CD), nuclear diameter (ND), cytoplasmic area (CA), nuclear area (NA), nucleus to cytoplasmic area ratio (NA/CA), cellular and nuclear pleomorphism, micronuclei (Mn), binucleation, bacterial colonies, and keratin flakes were evaluated using a light microscope and digital image analysis. Mean values for IDA and C groups were: bacterial colonies (1.88 and 0.65; P=0.002); CA (2209.88 and 1687.79 μm²; P=0.006); Mn (1.60 and 0.60; P=0.02). Significant increases in bacterial colonies, CA and Mn were seen for the IDA group. The number of cellular clumps, CD, ND, NA, NA/CA, cellular and nuclear pleomorphism, binucleation, and the number of keratin flakes didn’t show significant differences between studied groups (P>0.05). There wasn’t any significant difference with respect to overall atypia. This study revealed that IDA was able to induce significant changes in CA and Mn of the oral epithelial cells. Exfoliative cytology and cytomorphometry can be used as a tool to assess the mucosal changes in IDA patients.

Exfoliative cytology

Pleomorphism (cytology)

Buccal mucosa

Buccal swab

Nuclear atypia

Congo red

10.18502/acta.v58i9.4763

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Immunohistochemical Expression of SIRT1 in Oral Squamous Cell Carcinoma and its Relationship with Clinical-Pathological Factors

Journal of Contemporary Medical Sciences (2019)

Maryam Seyedmajidi Shima Nafarzadeh Arezoo Rayani Dariush Moslemi Ali Bijani

Objective: Oral squamous cell carcinoma (OSCC) is the most common oral cancer in the world that threatens public health. There are a number of molecular markers that can be used to improve TNM staging. One of these markers is SIRT1. We aimed to investigate the expression of SIRT1 in OSCC and its relationship with clinicopathological factors such as age, sex, location of tumor, smoking, clinical stage, grade of tumor, metastasis to lymph nodes in the neck and distant metastasis. Methods: This cross-sectional study was performed on 30 samples of OSCC and 30 samples of normal oral mucosa. Required clinical data were collected from patients. After immunohistochemistry staining for SIRT1 on sections prepared with paraffin blocks, the percentage of stained cells and staining intensity of the cells were evaluated in the terms of core and cytoplasmic aspects. Results: Positive expression of SIRT1 was seen in 93.3% and 96.7% of cells in the core and cytoplasm view, respectively, which was significantly higher than normal tissue (P=0.021 and 0.001, respectively). We found no significant relationship between the intensity and percentage of core and cytoplasmic staining of squamous cells as well as clinicopathological factors. Conclusion: The overexpression of SIRT1 in OSCC samples as compared with normal mouth tissue indicates its role in carcinogenesis. However, further studies on SIRT1 may shed more light on the treatment options of OSCC.

Oral mucosa

10.22317/jcms.v5i5.634

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Citations (4)

8527 POSTER Predictive Value of Epidermal Growth Factor (EGF) and Laminin-5 for Clinicopathologic Oral Squamous Cell Carcinoma(OSCC) Staging and Grading in Iranian Population

European Journal of Cancer (2011)

Shima Nafarzadeh Mohammad Moshref Zahra Taheri M. Nafarzadeh

Grading (engineering)

10.1016/s0959-8049(11)72169-4

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Citations (1)

Evaluating the Cell Proliferation Markers ki-67 and PCNA in Pathogenesis of Dentigerous Cyst