To extend application area of glutinous rice,the physical-chemical characteristics and processing properties of different sized glutinous rice powder ground by superfine grinding were compared.The resulted showed that with the powder diameter reduced,buck density,water solubility increased and pasted temperature reduced.In addition,freeze-thaw stability,enzymatic hydrolysis activity,high temperature water-binding capacity,transparency,depositing?performance and flowability?were improved dramatically after superfine ground.Results indicated that superfine grinding technology could improve the physical-chemical characteristics and processing properties of glutinous rice.
The study of the near-Moon plasma environment is one of the key scientific objectives of China's Chang'E-1 and Chang'E-2 missions.We investigate here specifically the interactions of the Lunar Magnetic Anomalies(LMA) with the Solar Wind(SW),based on the proton/ion data acquired by the Solar Wind Ion Detector(SWID) mounted on both lunar orbiters.Through the measured proton phase space distribution,we propose tentatively that the lunar magnetic anomalies could shield and heat the incident solar wind particles,with the possible formation of mini-magnetospheres near the anomaly.This study serves as one of the very few observational incidences of the presence of these plasma structures.This work,as well as follow-up studies,may contribute to the studies of both lunar space weathering and magnetospheric physics on scales where finite gyroradius effects are important.
Abstract Tailoring photocatalytic performance of TiO 2 through tuning crystal phase and hybridization is a big challenge in the field of photocatalytic application. In this study, the mesoporous TiO 2 (M‐TiO 2 ) particles with tunable crystal phase were synthesized using rape pollen as the bio‐template with and without acid treatment. It was found that the acidification pretreatment of pollen template had obvious effect on the crystal phase of TiO 2 . The pure anatase titanium dioxides (MA‐TiO 2 ) were prepared using the pure pollen as the template, while those using the acidified pollen template were anatase and rutile polycrystalline titanium dioxide (MAR‐TiO 2 ) which exhibited better catalytic activity. Furthermore, the hybridization between MAR‐TiO 2 and graphene oxide (MAR‐TiO 2 /GO) were achieved by the hydrothermal methods and their photocatalytic performance was studied by the degradation of methyl orange (MO) under ultraviolet and visible light. Compared with MAR‐TiO 2 , the MAR‐TiO 2 /GO nano‐composites possessed large specific surface area and narrow band gap due to the synergetic effect between MAR‐TiO 2 and GO, which increased photocatalytic activity towards the photo‐degradation of MO under ultraviolet and visible light. The degradation rates of MAR‐TiO 2 /GO under UV light and visible light were 92 % in 105 min and 97 % in 540 min, respectively.
Aim Nanoparticle study on monarch drug in the complex Huang Dai tablet-realgar,laying the groundwork for deeply investigating realgar particle size effect induced by cellular apoptosis,mechanism of action and new pharmaceutical technology.Methods High-energy ball-milling on ZJM-20/25 ball mill.Surface active transformation by surface active mass,preventing crystal form from transition and decomposition by thermogravimetric analysis(TGA);particle size analysis by laser scattering,analysis on tape of typical powders by scaning electron microscope(SEM) and transmission electron microscope.Results and Conclusion Decomposition temperatures of realgar in air and nitrogen are the same 260℃.In the high-energy ball-milling,realgar has not distinct crystal form transition and decomposition accept transformation towards non-crystal.With the time prolonged of ball-milling,the crystal particles of realgar powder rapidly transformed to nanoparticle level and there is the trend to non-crystal.In the water with active agent , ball mill can obtain masses with tiny uniform-distributed powders,the dispersion effect of sodium laurylsulfonate is better than that of sodium dodecyl sulfate. After this ball-milling,the powders at diameter 200nm reach above 85%,which are constituted of more tiny particles which are the tiny crystal particles below 20nm and non-crystal around it.
Clinical nurses are susceptible to compassion fatigue when exposed to various types of traumatic events in patients for extended periods of time. However, the developmental process, staging, and psychological responses distinct to each stage of compassion fatigue in nurses are not fully clarified. This study aimed to explore the processes of compassion fatigue and the psychological experiences specific to each phase of compassion fatigue among clinical nurses.Charmaz's Constructivist Grounded Theory methodology was used in this qualitative research. Semi-structured interviews were conducted with 13 clinical nurses with varying degrees of compassion fatigue from December 2020 to January 2021. Interview data were analyzed using grounded theory processes.The data were categorized into five separate categories and 22 sub-categories. This study found that the process of compassion fatigue is dynamic and cumulative, which was classified into five phases: compassion experience period, compassion decrement period, compassion discomfort period, compassion distress period, and compassion fatigue period.Clinical nurses who experience compassion fatigue may go through five stages that are stage-specific and predictable. The findings can shed light on local and global applications to better understand the problem of nurses' compassion fatigue. The interventions for addressing compassion fatigue in clinical nurses should be stage-specific, targeted, and individualized.
Abstract Ultrafast-charging energy storage devices are attractive for powering personal electronics and electric vehicles. Most ultrafast-charging devices are made of carbonaceous materials such as chemically converted graphene and carbon nanotubes. Yet, their relatively low electrical conductivity may restrict their performance at ultrahigh charging rate. Here, we report the fabrication of a porous titanium nitride (TiN) paper as an alternative electrode material for ultrafast-charging devices. The TiN paper shows an excellent conductivity of 3.67 × 10 4 S m −1 , which is considerably higher than most carbon-based electrodes. The paper-like structure also contains a combination of large pores between interconnected nanobelts and mesopores within the nanobelts. This unique electrode enables fast charging by simultaneously providing efficient ion diffusion and electron transport. The supercapacitors (SCs) made of TiN paper enable charging/discharging at an ultrahigh scan rate of 100 V s −1 in a wide voltage window of 1.5 V in Na 2 SO 4 neutral electrolyte. It has an outstanding response time with a characteristic time constant of 4 ms. Significantly, the TiN paper-based SCs also show zero capacitance loss after 200,000 cycles, which is much better than the stability performance reported for other metal nitride SCs. Furthermore, the device shows great promise in scalability. The filtration method enables good control of the thickness and mass loading of TiN electrodes and devices.
Topic: 4. Acute myeloid leukemia - Clinical Background: The prognosis of relapsed/refractory acute myeloid leukemia (R/R AML) is still poor and the treatment remains a challenging issue. Aims: To explore the efficacy and safety of donor-derived CLL-1 chimeric antigen receptor (CAR) T-cell therapy for R/R AML followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) bridging upon remission. Methods: A young male patient (18 years old) was diagnosed with CEBPA double-mutated AML. After initial chemotherapy, he achieved minimal residual disease (MRD)-negative complete remission (CR), that was followed by auto-HSCT. His leukemia disease was relapsed 6 months later. The salvage therapy with azacitidine and venetoclax was not helpful and his disease was deteriorated with 61% blasts in bone marrow (BM) and 63.18% blasts detected by flow cytometry (FCM) with a phenotype positive for CD34, CD117, HLA-DR, CD13, CD33, CD38, CD123 and CLL-1 upon admission. CAR T-cells targeting CLL-1 were manufactured using peripheral blood from a haploidentical donor, he received a total of 0.5*106/kg CAR T-cells with informed consent. The vital signs, complete blood counts, cytokines, serum ferritin, peripheral blood (PB) CAR T-cell counts, BM aspirate and MRD by FCM were monitored. Allo-HSCT from the same donor was started immediately after CR upon BM evaluation. Blood counts, BM aspirate and MRD, graft-versus-host disease (GVHD), and chimerism status were routinely monitored. Results: The patient developed fever at day 8 after CAR T-cells infusion, which peaked at 39.2°C. After supportive care, the temperature returned to normal range at day 10. There were no episodes of hypoxia, hypotension or immune effector cell-associated neurotoxicity syndrome (ICANS). The cytokine release syndrome (CRS) was assessed as grade 1. CAR T-cells expanded in PB at the peak of 9.4% in the whole T cells at day 8. The patient achieved CR with 0.29% MRD in BM by FCM at day 11. He was then bridged to allo-HSCT immediately. He achieved neutrophil engraftment at day 18 and platelet engraftment at day 26 after transplantation. Complete donor chimerism was observed at day 23. MRD negative CR in BM was achieved at day 23. The patient is currently 6 months after transplantation, with sustain MRD negative CR in BM, and no extramedullary disease or GVHD. Summary/Conclusion: Donor-derived CLL-1 CAR T-cell is effective and safe for treating R/R AML. Bridging to allo-HSCT immediately following CR may improve prognosis in these patients' population. (www.chictr.org.cn number, ChiCTR2200058607.) Keywords: AML, CAR-T, Allogeneic stem cell transplant
Metal–organic frameworks have shown promising applications as electrode materials for supercapacitors because of the high porosity and tunable structures, but their poor water stability and conductivity limit their capacitance and efficiency. To demonstrate how to overcome these drawbacks, three isostructural Ni–organic frameworks with [NiII2NiIII(μ3-OH)(COO)6] trinuclear building blocks are selected. Taking advantage of high-connected architectures, absence of open metal sites, and effective inner-cluster redox process, three Ni–organic frameworks all are stable in KOH electrolyte and exhibit a pseudo-capacitor behavior with high specific capacitances up to 394, 426, and 465 F g–1. The increasing porosity facilitates the diffusion of metal ions and electrons and thus increases their electrochemical performance. Furthermore, we demonstrate that the in situ fabrication of metal–organic frameworks with graphene oxide can effectively promote their supercapacitor performance. With a given 3% graphene oxide doping amount, the pseudo-capacitance values of the three compounds are improved to be 590, 576, and 504 F g–1, respectively. The values surpass those of most of the reported metal–organic framework supercapacitors up to now. The excellent supercapacitor performance of these Ni-MOFs provides a new route to explore potential electrode material by utilizing robust metal–organic frameworks based on [M3(μ3-OH)(COO)6] trinuclear building blocks.
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