Engy M. Akl

National Research Centre

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Elsevier eBooks (2025)

Asmaa S. Abd Elkarim Howaida I. Abd‐Alla Yasmina M. Abd‐Elhakim Mosaad A. Abdel‐Wahhab Wafaa F. Abusudah

10.1016/b978-0-443-21820-0.00002-7

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Modulation of oxidative damage and genotoxicity of biosynthesized zinc oxide nanoparticles via supplementation with modified cinnamaldehyde-loaded chitosan nanoparticles in mice

Deleted Journal (2024)

Mosaad A. Abdel Wahhab Aziza A. El Nekeety Asmaa S. Salman Zeinab K. Hamza Engy M. Akl

Synthesis of zinc oxide nanoparticles (Zn-NPs) via green method is an outstanding alternative to conventional/regular methods; however, the safety or toxicity of the biosynthesized ZnO-NPs in vivo is not fully explored. This study was conducted to evaluate the protective efficiency of cinnamaldehyde-loaded chitosan nanoparticles (Cin@CSNPs) against oxidative damage and genotoxicity of zinc oxide nanoparticles (ZnO-NPs) in mice. ZnO-NPs were biosynthesized using the extract of fresh leaves of Mentha pulegium L. Cin was extracted from cinnamon essential oil, and was loaded into chitosan nanoparticle (Cin@CSNPs). Both ZnO-NPs, Cin@CSNPs and CSNPs were characterized. The in vitro release of Cin@CSNPs was determined. In the biological study, 6 groups of male Balb/c mice were treated by gavage for 3 weeks as follows, control group, the group received ZnO-NPs (25 mg/kg b.w), the groups received Cin@CSNPs at low dose (50 mg/kg b.w) or high dose (100 mg/kg b.w), and the groups received ZnO-NPs plus Cin@CSNPs at the two tested doses. Blood and tissue samples were collected for different biochemical, genetical and histological studies. The particle size of ZnO-NPs, CSNPs, and Cin@CSNPs were (20.78 ± 2.6), (170.0 ± 3.7), and (218.23 ± 2.9) nm, and ξ-potential were (32.7 ± 4.6), (8.32 ± 0.27) and (4.8 ± 0.21), respectively. ZnO-NPs disturbed the biochemical and oxidative stress indices, AFP, CEA, TNF-α, chromosomal aberrations in somatic and germ cells, and sperm abnormality along with severe pathological changes in the hepatic, renal, and testicular tissues. Cin@CSNPs improved significantly all the parameters tested and the histological picture in a dose-dependent. Therefore, the biosynthesized ZnO-NPs exhibit oxidative damage and genotoxicity, and Cin@CSNPs have potential protective effects against the risks of ZnO-NPs and may be a promising tool to overcome the challenges of using Cin in food and pharmaceuticals applications.

10.26599/fshw.2024.9250374

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Manufacture of Functional Fat-free Cream Cheese Fortified with Probiotic Bacteria and Flaxseed Mucilage as a Fat Replacing Agent

Current Nutrition & Food Science (2020)

Engy M. Akl Samy M. Abdelhamid Suzanne M. Wagdy Heba H. Salama

Background: Cream cheese is a fatty cheese that is popular with many consumers and highly nutritious. There are many studies to reduce its fat content by fat replacers. Flaxseed mucilage has the potential for stabilizing emulsions, thickening foods and gelling solutions. High-quality cream cheese is manufactured by replacing fat with flaxseed mucilage. Objective: This study aimed to prepare probiotic-fortified and fat-free cream cheese using flaxseed mucilage as a fat replacer and as prebiotic. Methods: The mucilage was extracted and added at different concentrations to the manufactured cream cheese during processing. Chemical properties, microbiological analysis and sensory evaluation of the produced cream cheese were investigated. Results: The results showed that the addition of mucilage to the cream cheese increased the protein, ash and the total solids while the moisture content and the pH values were decreased. Cream cheese viscosity significantly increased with the addition of flaxseed mucilage and decreased during the storage period. The results also showed that the combination of flaxseed mucilage and probiotic bacteria has potent antibacterial activity against some pathogenic bacteria like Pseudomonas aeruginosa and Yersinia enterocolitica. The mucilage improved the texture, enhanced the survival of the probiotic bacteria and improved the overall sensorial characteristics of the cheese. Conclusion: The manufactured product could be suitable for consumers having some health issues related to the consumption of fat and as sources of probiotic bacteria.

Mucilage

Functional food

Health Benefits

10.2174/1573401316666200227112157

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Detection of Mycotoxigenic fungi associated with Pomegranate fruits (Punica granatum L.) and their control using Garden cress meal extract

Egyptian Journal of Chemistry (2024)

Engy M. Akl E. M. Embaby Marwa A. Younos

Pomegranate fruits (Punica granatum L.) are susceptible to fungal infection and subsequent contamination with mycotoxins. So the current work aimed at the detection of mycotoxigenic fungi associated with pomegranate fruits and their control using polyphenolic acetonic extract of garden cress meal (GCM). The occurrence of mycotoxigenic fungi was assessed. The polyphenolic compounds of the acetonic extract of GCM were elucidated. Each of its antioxidant activity and antifungal activity against isolated mycotoxigenic fungi were evaluated. The obtained data indicated that, 388 fungal isolates were detected. Rhizoctonia solani and Penicillium expansum were the most abundant fungi. Alternariol toxin was produced by Alternaria alternata (isolate No. 3) from location A, Aflatoxins were produced by A. parasiticus (isolate No.2) from location C and Patulin toxin was produced by Penicillium expansum (isolate No.13) from location B. Furthermore, the acetonic extract exhibited the highest phenolic compounds and antioxidant activity compared with other solvent extracts from GCM. Gallic acid was the major identified phenolic compound. The polyphenolic acetonic extract reduced significantly the fungal growth and spore viability of the mycotoxigenic fungi at all concentrations used compared with the control. Also, the growth inhibition and the spore viability reduction were increased by increasing the concentration used. It could be concluded that the polyphenolic acetonic extract of GCM had a significant antifungal effect against mycotoxigenic fungi attacks pomegranate fruits.

Punica

10.21608/ejchem.2024.239167.8674

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Citations (1)

Wound Dressings Based on Sodium Alginate–Polyvinyl Alcohol–Moringa oleifera Extracts

Pharmaceutics (2023)

Samir Kamel Sawsan Dacrory Peter Hesemann Nadir Bettache Lamiaa M. A. Ali

Biopolymers have significant pharmaceutical applications, and their blending has favorable characteristics for their pharmaceutical properties compared to the sole components. In this work, sodium alginate (SA) as a marine biopolymer was blended with poly(vinyl) alcohol (PVA) to form SA/PVA scaffolds through the freeze-thawing technique. Additionally, polyphenolic compounds in Moringa oleifera leaves were extracted by different solvents, and it was found that extracts with 80% methanol had the highest antioxidant activity. Different concentrations (0.0-2.5%) of this extract were successfully immobilized in SA/PVA scaffolds during preparation. The characterization of the scaffolds was carried out via FT-IR, XRD, TG, and SEM. The pure and Moringa oleifera extract immobilized SA/PVA scaffolds (MOE/SA/PVA) showed high biocompatibility with human fibroblasts. Further, they showed excellent in vitro and in vivo wound healing capacity, with the best effect noted for the scaffold with high extract content (2.5%).

Moringa

Polyvinyl Alcohol

Biocompatibility

Biopolymer

Vinyl alcohol

Sodium alginate

10.3390/pharmaceutics15041270

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Citations (10)

Exploiting Soybean and Flaxseed Meal Byproducts as Safe Weed Management Approaches in Onion Field

Journal of soil science and plant nutrition (2024)

Mona Adel El–Wakeel Ibrahim M. El–Metwally Salah A. A. Ahmed Engy M. Akl

Abstract The intensive and repeated use of chemical herbicides has led to the emergence of herbicide-resistant weeds, which, in addition to their environmental impacts, also pose significant threats to human and animal health. This study aimed to explore the potential of oilseed industrial wastes, specifically soybean and flaxseed meals, as safe and environmentally friendly bioherbicides for controlling weeds associated with onion crops. Two field experiments were conducted along two successive winter of 2020/21 and 2021/22. Treatments involved foliar spray of soybean and flaxseed meals in three different concentrations (15, 30 and 45%), mulching of seed meals, oxyfluorfen herbicide, two hand hoeing and untreated weedy check. The findings demonstrated that all weed control treatments significantly reduced weed density, biomass and nutrient uptake. Two hand hoeing, oxyfluorfen herbicide and the mulching of soybean and flaxseed meals alternated in the top rank for weed control, showing minimal significant differences among them. Following these effective treatments, soybean meal extracts at 45 and 30% exhibited notable weed control compared to the weedy check. The greatest enhancement in onion growth, yield characteristics and bulb quality was observed with the application of hand hoeing, soybean and flaxseed meal mulching treatments, with no significant differences between them. High-Performance Liquid Chromatography (HPLC) fractionation of both meals identified various phenolic acids at different concentrations. Practically, these safe efficient treatments proved progress on chemical herbicide. Hence, onion farmers are advised to apply soybean and flaxseed meals mulching safe treatments as alternative to harmful chemical herbicides under all experimental conditions.

10.1007/s42729-024-01948-x

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Skin mask hydrogel-based natural sources: Characterization and biological properties evaluations

Bioactive Carbohydrates and Dietary Fibre (2023)

Engy M. Akl Mohamed S. Hasanin Sawsan Dacrory

Distilled water

Mucilage

Carboxymethyl cellulose

10.1016/j.bcdf.2023.100355

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Citations (4)

Oilseeds Dietary Fiber and Their Health Benefits

Egyptian Journal of Chemistry (2023)

Engy M. Akl

10.21608/ejchem.2023.177503.7243

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Citations (1)

Preparation and characterization of novel antibacterial blended films based on modified carboxymethyl cellulose/phenolic compounds

Polymer Bulletin (2020)

Engy M. Akl Sawsan Dacrory Mohamed S. Abdel‐Aziz Samir Kamel Asmaa M. Fahim

Carboxymethyl cellulose

Biocompatibility

Active packaging

10.1007/s00289-020-03148-w

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Citations (48)

Hepatorenal protective effect of flaxseed protein isolate incorporated in lemon juice against lead toxicity in rats

Toxicology Reports (2019)

Rasha S. Mohamed Karem Fouda Engy M. Akl

Finding renal and hepatoprotective agents preferably with antioxidant activities against environmental pollutants especially lead which can adversely affect liver and kidney is a great demand. In the current study, flaxseed protein isolate (FPI) was extracted from defatted flaxseed meal. Amino acids profile, antioxidant capacity and solubility of the extracted FPI were determined. The solubility of FPI in the acidic media was exploited in preparation of lemon juice with FPI. Twenty four male rats were assigned to four groups; normal control, lead intoxicated (oral daily dose of 60 mg/kg b.w. in distilled water for four weeks), lead intoxicated and orally administrated with daily dose equal 1 ml of lemon juice as well as lead intoxicated and orally administered with FPI (daily dose equal 100 mg/kg) in 1 ml of lemon juice. The oral administration of FPI incorporated in lemon juice suppressed the elevation in kidney functions, lipid peroxidation of kidney tissues, urinary protein and creatinine as well as liver functions caused by lead intoxication. Additionally, lemon juice with FPI combated the reduction of GSH of kidney tissues. It was revealed also that lemon juice without FPI suppressed the elevation in kidney and liver functions caused by lead. It can be concluded that flaxseed protein isolate is a good source of protein with potent antioxidant activity. Additionally, lemon juice and FPI are considered protective sources of kidney and liver against lead toxicity.

Lemon juice

Nephrotoxicity

10.1016/j.toxrep.2019.12.001

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Citations (27)