Sohi Kang

Gyeongsang National University

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Changjong Moon

Chonnam National University

Joong‐Sun Kim

Chonnam National University

Sung‐Ho Kim

Korea Advanced Institute of Science and Technology

Taekyun Shin

Jeju National University

Sueun Lee

Chonnam National University Hospital

Yeonghoon Son

Korea Institute of Radiological and Medical Sciences

Miyoung Yang

Wonkwang University

Poornima D. E. Weerasinghe-Mudiyanselage

Chonnam National University

Mary Jasmin Ang

University of the Philippines Los Baños

Jinwook Kim

Chonnam National University

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Chonnam National University

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Seoul National University

Korea Institute of Oriental Medicine

Korea University

Yonsei University

Chonnam National University Hospital

Jeju National University

Kyungpook National University

Korea Research Institute of Bioscience and Biotechnology

Sungkyunkwan University

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Evaluation of the Efficacy of Zoledronic Acid and Amifostine on Radiation-induced Bone Loss in Mice

Journal of Radiation Protection and Research (2016)

Jinwook Kim Sueun Lee Sohi Kang Changjong Moon Jong-Choon Kim

Background This study investigated the effects of zoledronic acid (ZA) on radiation-induced bone loss in C3H/HeN mice. Materials and Methods C3H/HeN mice were divided into sham control and three irradiated groups (3 Gy, gamma ray). The irradiated mice were treated for 12 weeks with vehicle, amifostine (intraperitoneal injection), or ZA (subcutaneous injection). Grip strength, uterus weight, and serum alkaline phosphatase (ALP), and tartrate-resistant acid phosphatase (TRAP) levels were measured. Tibiae were analyzed using micro-computed tomography. Results and Discussion Treatment of ZA (100 μg·kg−1·week−1) significantly preserved trabecular bone volume, trabecular thickness, trabecular number, trabecular separation, bone mineral density of proximal tibia metaphysic, and cortical bone volume, but did not alter the uterus weight of the mice. The administration of ZA for 12 weeks lowered serum ALP and TRAP levels in irradiated mice, suggesting that ZA can reduce the bone turnover rate in mice. No differences were apparent between the amifostine-treated group and the irradiation control group. Conclusion The results indicate that ZA can prevent radiation-induced bone loss in mice. Keywords: Bone loss, Micro-computed tomography, Radiation, Zoledronic acid

Amifostine

Zoledronic Acid

10.14407/jrpr.2016.41.3.253

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Citations (1)

Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice

Brain Research Bulletin (2016)

Sueun Lee Miyoung Yang Juhwan Kim Yeonghoon Son Jinwook Kim

Neurotoxicity

10.1016/j.brainresbull.2016.01.002

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Citations (42)

Low Dose Rate Radiation Regulates M2-like Macrophages in an Allergic Airway Inflammation Mouse Model

Dose-Response (2022)

Wol Soon Jo Sohi Kang Soo Kyung Jeong Min Ji Bae Chang Geun Lee

We investigated the effects of low dose rate radiation (LDR) on M1 and M2 macrophages in an ovalbumin-induced mouse model of allergic airway inflammation and asthma. After exposure to LDR (1 Gy, 1.818 mGy/h) for 24 days, mice were euthanized and the changes in the number of M1 and M2 macrophages in the bronchoalveolar lavage fluid and lung, and M2-associated cytokine levels, were assessed. LDR treatment not only restored the M2-rich microenvironment but also ameliorated asthma-related progression in a macrophage-dependent manner. In an ovalbumin-induced mouse model, LDR treatment significantly inhibited M2, but not M1, macrophage infiltration. M2-specific changes in macrophage polarization during chronic lung disease reversed the positive effects of LDR. Moreover, the levels of cytokines, including chemokine (C-C motif) ligand (CCL) 24, CCL17, transforming growth factor beta 1, and matrix metalloproteinase-9, decreased in ovalbumin-sensitized/challenged mice upon exposure to LDR. Collectively, our results indicate that LDR exposure suppressed asthmatic progression, including mucin accumulation, inflammation, and Type 2 T helper (Th2) cytokine (interleukin (IL)-4 and IL-13) production. In conclusion, LDR exposure decreased Th2 cytokine secretion in M2 macrophages, resulting in a reduction in eosinophilic inflammation in ovalbumin-sensitized/challenged mice.

CCL17

Macrophage polarization

Allergic Inflammation

10.1177/15593258221117349

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N-[2-(4-Acetyl-1-Piperazinyl)Phenyl]-2-(3-Methylphenoxy)Acetamide (NAPMA) Inhibits Osteoclast Differentiation and Protects against Ovariectomy-Induced Osteoporosis

Molecules (2020)

Jinkyung Lee Sun Hee Ahn Zhihao Chen Sohi Kang Dong Kyu Choi

Osteoclasts are large, multinucleated cells responsible for bone resorption and are induced in response to the regulatory activity of receptor activator of nuclear factor-kappa B ligand (RANKL). Excessive osteoclast activity causes pathological bone loss and destruction. Many studies have investigated molecules that specifically inhibit osteoclast activity by blocking RANKL signaling or bone resorption. In recent years, we screened compounds from commercial libraries to identify molecules capable of inhibiting RANKL-induced osteoclast differentiation. Consequently, we reported some compounds that are effective at attenuating osteoclast activity. In this study, we found that N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(3-methylphenoxy)acetamide (NAPMA) significantly inhibited the formation of multinucleated tartrate-resistant acid phosphatase (TRAP)-positive cells from bone marrow-derived macrophages in a dose-dependent manner, without cytotoxic effects. NAPMA downregulated the expression of osteoclast-specific markers, such as c-Fos, NFATc1, DC-STAMP, cathepsin K, and MMP-9, at the transcript and protein levels. Accordingly, bone resorption and actin ring formation were decreased in response to NAPMA treatment. Furthermore, we demonstrated the protective effect of NAPMA against ovariectomy-induced bone loss using micro-CT and histological analysis. Collectively, the results showed that NAPMA inhibited osteoclast differentiation and attenuated bone resorption. It is thus a potential drug candidate for the treatment of osteoporosis and other bone diseases associated with excessive bone resorption.

Cathepsin K

Multinucleate

10.3390/molecules25204855

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Citations (3)

Trimethyltin-induced hippocampal neurodegeneration: A mechanism-based review

Brain Research Bulletin (2016)

Sueun Lee Miyoung Yang Jinwook Kim Sohi Kang Juhwan Kim

Neurotoxicity

10.1016/j.brainresbull.2016.07.010

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Citations (71)

Anti-Amnesic Effect of Agastache rugosa on Scopolamine-Induced Memory Impairment in Mice

Pharmaceuticals (2024)

Sohi Kang Nari Lee Bokyung Jung Huiyeong Jeong Changjong Moon

, a traditional Asian herbal medicine, is primarily used for digestive problems; yet, its cognitive benefits remain unexplored. This study evaluated the anti-amnesic effects of

Scopolamine

Memory Impairment

10.3390/ph17091173

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Impact of diesel particulate matter on the olfactory bulb of mice: insights from behavioral, histological, and molecular assessments

Molecular & Cellular Toxicology (2023)

Jeongmin Lee Poornima D. E. Weerasinghe-Mudiyanselage Bohye Kim Sohi Kang Joong‐Sun Kim

KEGG

10.1007/s13273-023-00414-6

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Citations (6)

Olaparib synergically exacerbates the radiation-induced intestinal apoptosis in mice

Molecular & Cellular Toxicology (2024)

Sohee Jeong Jeongmin Lee Jun Hong Park Yeonghoon Son Hae‐June Lee

Olaparib

PARP inhibitor

10.1007/s13273-023-00421-7

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Author response for "Melatonin alters neuronal architecture and increases cysteine‐rich protein 1 signaling in the male mouse hippocampus"

Mary Jasmin Ang Sohi Kang Changjong Moon

10.1002/jnr.24708/v3/response1

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Camellia sinensis (L.) Kuntze Extract Attenuates Ovalbumin-Induced Allergic Asthma by Regulating Airway Inflammation and Mucus Hypersecretion

Pharmaceutics (2023)

Sohi Kang Hyun-Yong Kim A Yeong Lee Hyo Seon Kim Jun Hong Park

Asthma is a pulmonary disease induced by the inhalation of aeroallergens and subsequent inappropriate immune responses. Camellia sinensis (L.) Kuntze has been evaluated as an effective antioxidant supplement produced from bioactive compounds, including flavonoids. In this study, we aimed to determine the effects of Camellia sinensis (L.) Kuntze extract (CE) on ovalbumin-induced allergic asthma. The components of CE were analyzed using high-performance liquid chromatography (HPLC) chromatogram patterns, and asthmatic animal models were induced via ovalbumin treatment. The antioxidant and anti-inflammatory effects of CE were evaluated using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), and nitric oxide (NO) assays. Seven compounds were detected in the CE chromatogram. In the ovalbumin-induced mouse model, CE treatment significantly decreased the inflammation index in the lung tissue. CE also significantly decreased eosinophilia and the production of inflammatory cytokines and OVA-specific IgE in animals with asthma. Collectively, our results indicate that CE has anti-inflammatory and antioxidant activities, and that CE treatment suppresses asthmatic progression, including mucin accumulation, inflammation, and OVA-specific IgE production.

ABTS

10.3390/pharmaceutics15092355

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Citations (3)