Carlos Acosta‐Olivo

Universidad Autónoma de Nuevo León

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Félix Vílchez‐Cavazos

Universidad Autónoma de Nuevo León

Víctor M. Peña‐Martínez

Universidad Autónoma de Nuevo León

Mario Simental‐Mendía

Universidad Autónoma de Nuevo León

Yadira Tamez-Mata

Universidad Autónoma de Nuevo León

Gregorio Villarreal-Villarreal

Universidad Autónoma de Nuevo León

Rodolfo Morales-Ávalos

Universidad Autónoma de Nuevo León

Luis E. Simental‐Mendía

Mexican Social Security Institute

Oscar Fernando Mendoza-Lemus

Universidad Autónoma de Nuevo León

Rodrigo Enrique Elizondo‐Omaña

Universidad Autónoma de Nuevo León

Jaime Blázquez-Saldaña

Universidad Autónoma de Nuevo León

Cooperative Institutions

Universidad Autónoma de Nuevo León

120

Hospital Universitario Dr José Eleuterio Gonzalez

Universidad Nacional Autónoma de México

Universidad Complutense de Madrid

Massachusetts General Hospital

Tecnológico de Monterrey

Hospital Clínic de Barcelona

Hispanics in Philanthropy

Consejo Superior de Investigaciones Científicas

Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas

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The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

International Journal of Rheumatic Diseases (2017)

Domingo Garay‐Mendoza Laura Villarreal‐Martínez Alejandra Garza‐Bedolla Daniela Michelle Pérez‐Garza Carlos Acosta‐Olivo

Abstract Aim Management of osteoarthritis ( OA ) is basically symptomatic. Recently, stem cells ( SC ) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra‐articular injection of in vivo stimulated bone marrow SC could lead to an improvement in pain management and quality of life in patients with knee OA . Method This was a prospective, open‐label, phase I/ II clinical trial to assess the safety and efficacy of a single intra‐articular injection of autologous stimulated bone marrow stem cells ( BM ‐ SC ) in patients with knee OA . Individuals of both genders older than 30 years with confirmed diagnosis of OA who signed informed consent were included in two groups: SC group received in vivo BM stimulation with subcutaneous administration of granulocyte colony stimulating factor (G‐ CSF ). SC were obtained by BM aspiration and administered in a single intra‐articular injection. The control group received exclusively oral acetaminophen. Visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index scores were performed at 1 week, 1 month and 6 months in both groups. This trial was registered in ClinialTrials.gov NCT 01485198. Results A total of 61 patients were included. Socio‐demographic characteristics, OA grades and initial scores were similar in both groups. The BM ‐ SC group showed significant improvement in knee pain and quality of life during the 6‐month follow‐up. Conclusion The study demonstrates feasibility and supports efficacy of a completely ambulatory procedure in treatment of knee OA .

Knee pain

10.1111/1756-185x.13139

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Citations (78)

Polio, approaching eradication as a result of vaccination

Medicina Universitaria (2021)

José A. Moreno-González Carlos Acosta‐Olivo

Polio Vaccination

Poliomyelitis eradication

10.24875/rmu.m21000058

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Reversal of high-glucose–induced transcriptional and epigenetic memories through NRF2 pathway activation

Life Science Alliance (2024)

Martí Wilson-Verdugo Brandon Bustos-García Olga Adame-Guerrero Jaqueline Hersch-González Nallely Cano-Domínguez

Diabetes complications such as nephropathy, retinopathy, or cardiovascular disease arise from vascular dysfunction. In this context, it has been observed that past hyperglycemic events can induce long-lasting alterations, a phenomenon termed "metabolic memory." In this study, we evaluated the genome-wide gene expression and chromatin accessibility alterations caused by transient high-glucose exposure in human endothelial cells (ECs) in vitro. We found that cells exposed to high glucose exhibited substantial gene expression changes in pathways known to be impaired in diabetes, many of which persist after glucose normalization. Chromatin accessibility analysis also revealed that transient hyperglycemia induces persistent alterations, mainly in non-promoter regions identified as enhancers with neighboring genes showing lasting alterations. Notably, activation of the NRF2 pathway through NRF2 overexpression or supplementation with the plant-derived compound sulforaphane, effectively reverses the glucose-induced transcriptional and chromatin accessibility memories in ECs. These findings underscore the enduring impact of transient hyperglycemia on ECs' transcriptomic and chromatin accessibility profiles, emphasizing the potential utility of pharmacological NRF2 pathway activation in mitigating and reversing the high-glucose-induced transcriptional and epigenetic alterations.

10.26508/lsa.202302382

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A Comparison of Botulinum Toxin A and Intralesional Steroids for the Treatment of Plantar Fasciitis

Foot & Ankle International (2013)

Jorge Elizondo-Rodríguez Yariel Araujo-Lopez J. Alberto Moreno-Gonzalez Eloy Cárdenas‐Estrada Oscar Fernando Mendoza-Lemus

Background: The objective of this study was to compare intramuscularly applied botulinum toxin A (BTX-A) in the gastroc-soleus complex with intralesional steroids for the treatment of plantar fasciitis. Methods: The patients were randomly divided into 2 groups according to the treatment received. The patients were evaluated over 6 months. The evaluation scores included the Visual Analog Scale (VAS), Maryland Foot and Ankle, Foot and Ankle Disability Index (FADI), and American Orthopaedic Foot and Ankle Society (AOFAS) score. Moreover, patients were instructed to perform plantar fascia stretching exercises over the course of the study. The final number of patients was 36, of whom 19 received BTX-A (10 men and 9 women) and 17 (6 men and 11 women) received steroids. Results: When compared to patients who received steroids, the patients who received BTX-A exhibited more rapid and sustained improvement over the duration of the study. Conclusion: A combination of BTX-A and plantar fascia stretching exercises yielded better results for the treatment of plantar fasciitis than intralesional steroids. Level of Evidence: Level I, therapeutic studies.

Plantar fascia

Foot (prosody)

10.1177/1071100712460215

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Citations (58)

Delayed union of humeral shaft fractures: comparison of autograft with and without platelet-rich plasma treatment: a randomized, single blinded clinical trial

Archives of Orthopaedic and Trauma Surgery (2017)

Carlos Acosta‐Olivo Abiel Garza-Borjón Mario Simental‐Mendía Félix Vílchez‐Cavazos Yadira Tamez-Mata

Humeral shaft

10.1007/s00402-017-2736-5

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Citations (27)

Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials

Rheumatology International (2018)

Mario Simental‐Mendía Adriana Sánchez‐García Félix Vílchez‐Cavazos Carlos Acosta‐Olivo Víctor M. Peña‐Martínez

WOMAC

Chondroitin

10.1007/s00296-018-4077-2

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Citations (102)

Anthropometric Landmarks for Posterior Cruciate Ligament Reconstruction in Anatomical Position Referencias Antropométricas para la Reconstrucción del Ligamento Cruzado Posterior en Posición Anatómica

Gustavo Adolfo Compeán-Martínez Rodolfo Morales-Ávalos Félix Vílchez‐Cavazos Carlos Acosta‐Olivo Fernando Mendoza-Lemus

COMPEAN-MARTINEZ, G. A.; MORALES-AVALOS, R.; VILCHEZ-CAVAZOS, F.; ACOSTA-OLIVO, C.; MENDOZA-LEMUS, O. F.; GARZA-CASTRO, O.; ELIZONDO-OMANA, R. E. & GUZMAN-LOPEZ, S. Anthropometric landmarks forposterior cruciate ligament reconstruction in anatomical position. Int. J. Morphol., 33(2):678-684, 2015.SUMMARY: To determine viable anatomical landmarks allowing for accurate femoral and tibial tunnel placement in anatomicalposition during posterior cruciate ligament (PCL) reconstruction. Ten knees were dissected to analyze femoral and tibial PCL in sertionmeasurements and the features specific to the PCL and its fascicles. The clock hands system was used to measure femoral inserti ons. Themeniscus and anterior cruciate ligament (ACL) were used as landmarks to measure tibial insertions. The PCL and its correspondingfascicle characteristics were determined by its femoral insertion, central portion and tibial insertion. The mean lengths between thecentral point of the PCL footprint and the articular cartilage border at 12:00 h were 17.23 mm ( ±3.94) and 17.73 mm ( ±4.11) for the rightand left knees, respectively. The anterior-posterior mean lengths for the PCL were 11.94 mm ( ±5.08) between the posterior PCL borderand the anterior PCL border. The mean lengths were 33.52 mm ( ±3.49) from the medial border of the lateral meniscus to the lateral PCLborder and 32.24 mm (±2.28) from the medial border of the medial meniscus to the medial PCL border. From the anteroposteriorviewpoint, the anterolateral fascicle is greater than the posteromedial one in its femoral and tibial insertions and in its cen tral portion. Aquantitative data collection summary was conducted with different PCL variables, along with its fascicles and their various fem oral andtibial bony landmarks. Various measurements were obtained, indicating the high functionality shared by the PCL fascicles. Lengthsreported for insertions are practical landmarks for the locations of femoral and tibial tunnels during posterior cruciate ligam ent plasty. Wemust take into account native PCL form to avoid oversizing the graft during reconstruction and to avoid a possible clamping of the graftwith the surrounding structures.KEY WORDS: Posterior cruciate ligament; Femoral tunnels; Reconstruction; Anatomy; Landmark.

Posterior cruciate ligament

Medial meniscus

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Supracondylar humeral fractures and lateral elbow condyle fractures in children: association between body weight, clinical signs, and fracture severity

Minerva Pediatrics (2020)

Víctor M. Peña‐Martínez Yadira Tamez-Mata Mariel GARCÍA-LIMÓN Mario Simental‐Mendía J. Fernando DE LA GARZA-SALAZAR

The objective of our study was to investigate the association between body weight, clinical signs and surgical time, and the severity of elbow fractures sustained exclusively by a ground-level fall in children.Patients aged 2-11 years with elbow fracture caused exclusively by a ground-level fall were included. BMI was plotted on the sex-specific BMI-for-age percentile growth chart to obtain the BMI percentile. The elbow fractures were classified according to Gartland Classification for supracondylar fractures and the Song Classification for lateral humeral condyle fracture. Our main outcome measurement was Body Mass Index and fracture severity according Gartland or Song classifications.A total of 175 patients with elbow fractures were included in this study. The mean age of total population was 5.4 years (±2.4). The majority of our patients were male (61.7%), nearly of 48% were overweight or obese patients. The ecchymosis and puckering were the clinical sign more frequent in more severe fractures.Our data presented did not observe a direct relation between obesity and the severity of elbow humeral fractures in the pediatric population with a ground-level fall.

10.23736/s0026-4946.20.05585-1

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Citations (4)

The use of platelet-rich plasma in studies with early knee osteoarthritis versus advanced stages of the disease: a systematic review and meta-analysis of 31 randomized clinical trials

Archives of Orthopaedic and Trauma Surgery (2022)

Félix Vílchez‐Cavazos Jaime Blázquez-Saldaña Augusto Gamboa-Alonso Víctor M. Peña‐Martínez Carlos Acosta‐Olivo

Web of science

10.1007/s00402-021-04304-1

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Citations (20)

Spondylodiscitis treated with freeze-dried bone allograft alone or combined with autograft: A randomized and blinded trial

Journal of orthopaedic surgery (2021)

Oscar Armando Martínez-Gutiérrez Víctor M. Peña‐Martínez Adrián Camacho-Ortíz Félix Vílchez‐Cavazos Mario Simental‐Mendía

Purpose: To compare the bone fusion of freeze-dried allograft alone versus freeze-dried allograft combined autograft in spinal instrumentation due to spondylodiscitis. Methods: A randomized prospective trial of patients with spondylodiscitis treated with surgical debridement and spinal fixation with freeze-dried bone allograft and autograft (Group 1) or freeze-dried bone allograft alone (Group 2) was performed. Patient follow-up was assessed with a CT-scan for bone fusion; consecutive serum inflammatory marker detection (C-reactive protein, [CRP], and erythrocyte sedimentation rate, [ESR]) and clinical assessment (pain, functional disability, and spinal cord injury recovery) were other outcome parameters. The primary outcome was the grade of bone allograft integration with the scale of Tan (which ranges from 1 to 4, with lower scores indicating a better fusion rate) at 1 year after surgery. Results: A total of 20 patients were evaluated, 13 (65%) men and 7 (35%) women with a mean age of 47.2 (±14.3) years. Homogeneous distribution of demographic data was observed. A similar satisfactory bone graft fusion grade was observed in both graft groups at 1 year after surgery (p = 1.0000). Serum inflammatory markers gradually decreased in both groups after surgical intervention (CRP, p < 0.001; ESR, p < 0.01). At one-year follow-up, gradual improvement of pain, functional disability, and neurological spinal injury recovery in both graft groups were achieved. Conclusion: Freeze-dried allograft alone could be a therapeutic option for spinal fixation surgery due to spondylodiscitis since it achieves a satisfactory graft fusion rate and clinical improvement. Level of Evidence: Level 1. Treatment register: NCT03265561

Spondylodiscitis

Erythrocyte sedimentation rate

Debridement (dental)

10.1177/23094990211019101

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Citations (5)