Objective:To explore the association between polymorphism of serotonin transporter promoter region(5-HTTLPR) and the pathogenesis of obsessive compulsive disorder in the Han nationality. Method: Patients with obsessive-compulsive disorder and normal controls were genotyped for the 5-HTTLPR with polymerase chain reaction amplification fragment length polymorphism techniques. Results:There was no significant difference between patients with obsessive compulsive disorder and normal controls in the frequencies of genotype for 5-HTTLPR.There was a significant difference on allele frequency of 5-HTTLPR, Allele L of 5-HTTLPR positively associated with obsessive compulsive disorder(OR=1.929,P0.05). Conclusion: There was a relationship between Allele L of 5-HTTLPR gene polymorphism and obsessive compulsive disorder in the Han nationality. Allele L may be a risk factor to the pathogenesis of obsessive-compulsive disorder.
