Muhammad Naeem Faisal

University of Agriculture Faisalabad

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Bilal Aslam

University of Agriculture Faisalabad

Faqir Muhammad

Bahauddin Zakariya University

Humaira Muzaffar

Government College University, Faisalabad

Haseeb Anwar

Government College University, Faisalabad

Wafa Majeed

University of Agriculture Faisalabad

Asif Hussain

University of Agriculture Faisalabad

Ghulam Hussain

Government College University, Faisalabad

Masood Sadiq Butt

University of Agriculture Faisalabad

Mian Kamran Sharif

University of Faisalabad

Junaid Khan

Hebei University of Technology

Cooperative Institutions

University of Agriculture Faisalabad

140

University of Faisalabad

Government College University, Faisalabad

Islamia University of Bahawalpur

COMSATS University Islamabad

Bahauddin Zakariya University

University of Veterinary and Animal Sciences

University of Sargodha

The University of Agriculture, Peshawar

King Saud University

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Curcumin Co-Encapsulation Potentiates Anti-Arthritic Efficacy of Meloxicam Biodegradable Nanoparticles in Adjuvant-Induced Arthritis Animal Model

Biomedicines (2023)

Bilal Aslam Asif Hussain Muhammad Naeem Faisal Zia ud Din Sindhu Rifat Ullah Khan

This study aimed to evaluate the anti-arthritic activity of curcumin and meloxicam co-loaded PLGA nanoparticles in adjuvant-induced arthritic rats. PLGA nanoparticles encapsulating curcumin (nCur) and meloxicam (nMlx) alone and in combination (nCur/Mlx) were used to characterize zeta size and potential, polydispersity index, encapsulation efficiency (%), compound-polymer interactions (FT-IR analysis), and surface morphology (SEM imaging). In vivo, Complete Freund's adjuvant-induced arthritic rats were intraperitoneally (i.p.) administered with curcumin, meloxicam, curcumin plus meloxicam, nCur, nMlx, and nCur/Mlx for 28 consecutive days. Results showed that nCur, nMlx, and nCur/Mlx significantly (p ≤ 0.05) reduced paw swelling and arthritic score, restored body weight and the immune organ index (thymus and spleen), as well as attenuated serum inflammatory markers (RF, CRP, and PGE2) and oxidative stress parameters (MDA, SOD, and CAT) in adjuvant-induced arthritic rats compared to free compounds. In addition, mono- and dual-compound-loaded nanoparticles significantly (p ≤ 0.05) down-regulated pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6), up-regulated anti-inflammatory cytokines (IL-4, IL-10, and IFN-γ), and modulated OPG and RANKL expressions in paw tissue. The aforementioned results were further confirmed through radiological and histopathological examinations. Furthermore, the anti-arthritic effect of nCur/Mlx was notably (p ≤ 0.05) enhanced compared to nCur or nMlx alone. In conclusion, the co-nanoencapsulation of curcumin could potentiate the anti-arthritic activity of meloxicam and could provide a novel therapeutic approach for the formulation of nanocarrier pharmaceutical products for the management of arthritis.

Meloxicam

PLGA

10.3390/biomedicines11102662

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Antipyretic and antinociceptive potential of Ricinus communis L. and Withania somnifera L. hydroalcoholic extracts in Wistar rats: A comparative study.

PubMed (2021)

Asif Hussain Bilal Aslam Faqir Muhammad Muhammad Naeem Faisal

The present study was designed to evaluate the antipyretic and antinociceptive activities of R. communis leaves and W. somnifera roots hydroalcoholic extracts in Wistar rats. To assess the antipyretic activity, Brewer's yeast suspension was used to induce hyperthermia. Antinociceptive activity was observed using acetic acid-induced abdominal writhing, formalin-induced paw licking reflex and heat-induced pain models. R. communis and W. somnifera extracts were used at 150, 250 and 500mg/kg. Results showed that administration of both plants significantly (p<0.001) lowered rectal temperature (°C) in a dose-dependent manner from 1h to 4h of study. R. communis and W. somnifera extracts showed a dose-dependent reduction in abdominal writhing induced by acetic acid and decreased the paw licking reflex in formalin-induced nociceptive response. In the heat test, R. communis and W. somnifera extracts exhibited significant (p<0.001) analgesic effects evidenced as an increase in latency time. However, R. communis exhibited prominent antipyretic and antinociceptive activities at 250 and 500mg/kg as compared to W. somnifera. Conclusively, R. communis and W. somnifera could be a potential source of antipyretic and analgesic agents which require further studies.

Licking

Antipyretic

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Nutraceutical Impact of Pumpkin Seed Oil on Expression Levels of EZH-2 and KRT-14 Genes against DSS-induced Inflammatory Bowel Disease in the Rat Model

Cell Biochemistry and Biophysics (2025)

Asma Mukhtar Imran Mukhtar Humaira Muzaffar Muhammad Naeem Faisal Kashif-ur-Rehman Khan

Histopathology

10.1007/s12013-024-01629-7

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Simulation Models for Comparison of Toxicities of Anticancer Drugs

Annals of Punjab Medical College (APMC) (2019)

Muhammad Adeel Muhammad Khalid Muhammad Asif Muhammad Naeem Faisal

This retrospectivestudy presents simulation models foranalyzing toxicities of doxorubicin and docetaxel, bothin combination of cyclophosphamide (AC and TC). Itcomparedtheir side effectsduring postoperative chemotherapy of the treated Pakistani breast tumor patients. Between September 2015 and September 2017, patients out of 356 received TC (600 mg/m2 of cyclophosphamide, 75 mg/m2 of docetaxel) and 168received AC (600 mg/m2of cyclophosphamide,60 mg/m2 of doxorubicin). Using simulation and modeling the study presents two simulation models called SMG1SE, (Simulation Model for Side Effects listed in Group 1) and SMG2SE (Simulation Model for Side Effects listed in Group 2). SMG1SE shows drugs toxicity based on side effects, listed in group 1 including muscles pain, mild anemia, moderate anemia, blood transfusion, weight loss, and hands burning. SMG2SE shows toxicity basedon side effects, listed in group 2 including vomiting, change in taste, sores in throat, diarrhea, tiredness, and dizziness.At α=0.05, chi-squared test was used for statistical analysis.It was observed no significant difference between the percentagesof patientswith extreme tiredness, stability, mild anemia,vomiting, and diarrhea forP-valueremained>0.05. Though, AC(P-value<0.05)was found less toxic by 25.7%, 22.6%, 25.3%,20.8%,16.4%, and 12.4% and compared to TC for muscle pain,changes in taste, burning hands,moderate anemia, needing blood transfusion, and change in hemoglobin level, respectively, but TC was found less toxic by 32.5%, 26.3%, and 52.9% for weight loss,sores in throat and mouth, and dizziness respectively.At 24 months, AC remainedless toxic than TC.

Sore throat

Muscle cramp

10.29054/apmc/2019.691

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Therapeutic intervention of Chenopodium quinoa seeds extract against cigarette smoke-induced acute lung injury

Research Square (Research Square) (2022)

L. Majeed Muhammad Naeem Faisal Junaid Khan Wafa Majeed

Abstract Lung is the prime organ for respiration, facing health issues when exposed to environment. Acute lung injury due to direct and indirect stimuli provokes an inflammatory response resulting in alveolar epithelial barrier dysfunction, increase membrane permeability and ultimately pulmonary edema. Approximately eight million deaths were reported each year with direct or indirect exposure to smoke. Current study was designed to elucidate the therapeutic efficacy of Chenopodium quinoa seeds extract against cigarette smoke-induced pathophysiological alterations in the lung parenchyma. Results revealed that serum oxidative marker (TOS) were significantly (P <0.05) reduced in all the treatment groups in comparison to control positive group while, total antioxidant capacity (TAC) was significantly (P <0.05) increased in all the treatment groups in comparison to control positive group. Gene expression analysis result indicated highly significant (P <0.05) down regulation of Nrf-2 signaling pathway (Keap-1, NFR-1 and Nfe-212) and dual-oxidases (Duox, Duoxa-1, and Duox-2) in all the treatment groups in comparison to control positive group. Histopathology of the lung tissues indicated the decreased infiltration of leukocytes at the site of alveoli and decreased hyaline membrane thickening in all the treatment groups in comparison to control positive group. Overall results concluded that the therapeutic efficacy of Chenopodium quinoa seeds extract against cigarette smoke-induced pathophysiological alterations in the lung parenchyma due to its anti-inflammatory and antioxidant efficacy to restore lung homeostasis.

Parenchyma

Pathophysiology

10.21203/rs.3.rs-1488923/v1

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The antioxidant and hepatoprotective potential of Solanum nigrum against oxidative stress

Research Square (Research Square) (2022)

Amna Alam Amna Sahar Aysha Sameen Muhammad Naeem Faisal

Abstract The present study aimed to evaluate the phytochemical screening and in vivo antioxidant potential of Solanum nigrum against phenylhydrazine induced liver injury. The Solanum nigrum extract has significant in vitro antioxidant activity. Moreover, HPLC analysis of ethanolic Solanum nigrum extract showed revealed the presence of phenolic compounds. The Sprague Dawley rats were divided into four groups for in vivo analysis: G1 (negative control group), G2 (positive control group), G3 (rats receiving standard drug), and G4 (rats receiving Solanum nigrum extract i.e.1.0g/kg b.w.). The Solanum nigrum also reduced the level of liver enzyme, and bilirubin. An opposite trend was seen in the case of albumin, catalase, and superoxide dismutase. Histology slides also showed the normal cell structure of hepatocytes. Gene expression analysis demonstrates the upregulation of antioxidant and anti-apoptosis genes. Conclusively, Solanum nigrum has the ability to alleviate liver toxicity in an animal model by reducing oxidative stress and downregulating the apoptosis genes.

Solanum nigrum

Phytochemical

10.21203/rs.3.rs-1590719/v1

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De novo comprehensive transcriptome assembly and analysis from different organs of Ruta chalepensis revealed genes involved in rutin biosynthesis.

International Journal of Agriculture and Biology (2020)

Eslam M. Abdel-Salam Abdulrahman A. Alatar Ahmed A. Qahtan Muhammad Naeem Faisal

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Ultrasound-assisted ethanolic extract of Morus nigra fruit alleviates oxidative stress and inflammation via Keap1/Nrf2, dual oxidases, and JAK/STAT pathways

Journal of Agriculture and Food Research (2024)

Maria Maqsood Raakia Anam Saeed Muhammad Issa Khan Muhammad Naeem Faisal Hamna Anam Saeed

KEAP1

10.1016/j.jafr.2024.101378

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High fat diet induces metabolic disorder in the fruit fly Drosophila melanogaster

Muhammad Naeem Faisal

Different diets have a great impact on our health. HFD has adverse effects on the metabolism and the structure and physiology of the gastrointestinal tract. High fat diet (HFD) is a major reason for the epidemic development of various metabolic disorders. In Drosophila melanogaster HFD triggers the proliferation and differentiation of the intestinal epithelium leading to renewal of the epithelial layer. HFD and microflora trigger inflammation and permeability through disruption of tight junctions within the epithelium. In the fly, proliferation and differentiation of the gut epithelium results from activation of various signalling pathways including stress responses within the ECs finally leading to release of upd3. This triggers ISC proliferation and differentiation. The interplay role of HFD behind the activation of JNK, Nrf2, notch and Ca2+-signaling pathways are remains to be elucidated. Moreover, HFD affects gastric emptying time and slows down the defecation rate. HFD modulates the metabolisms of lipids being a major cause of metabolic disorder increasing the number of microbiota community. Manifestation of metabolic disorder in the gut may be causally associated with several chronic diseases such as IBD, IBS, insulin resistance and ultimately with cancer.

Intestinal epithelium

Metabolic pathway

Intestinal Permeability

Metabolic disorder

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Gingerol nanoparticles attenuate complete Freund adjuvant-induced arthritis in rats via targeting the RANKL/OPG signaling pathway

Inflammopharmacology (2024)

Rida Siddique Faqir Muhammad Muhammad Naeem Faisal Bushra Akhtar Ammara Saleem

10.1007/s10787-024-01537-5

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