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Christian Lange‐Asschenfeldt

Asklepios Klinik Langen

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Otto Benkert

University of Applied Sciences Mainz

Ion Anghelescu

Klinik für Psychosomatik

Gerhard Gründer

Central Institute of Mental Health

Christoph Fehr

Vitos

Axel Steiger

Max Planck Institute of Psychiatry

Philip Heiser

Ferring Pharmaceuticals (Denmark)

Francesca Regen

Charité - Universitätsmedizin Berlin

Christoph Hiemke

Johannes Gutenberg University Mainz

Matthias J. Müller

University Hospital Frankfurt

Armin Szegedi

AbbVie (United States)

Cooperative Institutions

FH Aachen

Philipps University of Marburg

Heinrich Heine University Düsseldorf

Klinik und Poliklinik für Psychiatrie und Psychotherapie

Johannes Gutenberg University Mainz

Düsseldorf University Hospital

Ludwig-Maximilians-Universität München

Charité - Universitätsmedizin Berlin

Universität Ulm

University of Applied Sciences Mainz

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Transient reduction of spontaneous neuronal network activity by sublethal amyloid β (1–42) peptide concentrations

Journal of Neural Transmission (2009)

Philipp Görtz Jessica Opatz Mario Siebler Susanne Aileen Funke Dieter Willbold

Amyloid (mycology)

Amyloid beta

Pathophysiology

10.1007/s00702-009-0188-y

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Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/γ‐aminobutyric acid release and biosynthesis

Journal of Neuroscience Research (2005)

Kunjan R. Dave Christian Lange‐Asschenfeldt Ami P. Raval Ricardo Prado Raul Busto

Abstract Excitotoxicity is recognized to play a major role in cerebral ischemia‐induced cell death. The main goal of the present study was to define whether our model of ischemic preconditioning (IPC) promotes a shift from excitatory to inhibitory neurotransmission during the test ischemia to diminish metabolic demand during the reperfusion phase. We also determined whether γ‐aminobutyric acid (GABA) played a role in IPC‐induced neuroprotection. Ten minutes of cerebral ischemia was produced by tightening the carotid ligatures bilaterally following hypotension. Samples of microdialysis perfusate, representing extracellular fluid, were analyzed for amino acid content by HPLC. IPC promoted a robust release of GABA after lethal ischemia compared with control rats. We also observed that the activity of glutamate decarboxylase (the predominant pathway of GABA synthesis in the brain) was higher in the IPC group compared with control and ischemic groups. Because GABA A receptor up‐regulation has been shown to occur following IPC, and GABA A receptor activation has been implicated in neuroprotection against ischemic insults, we tested the hypothesis that GABA A or GABA B receptor activation was neuroprotective during ischemia or early reperfusion by using an in vitro model (organotypic hippocampal slice culture). Administration of the GABA B agonist baclofen during test ischemia and for 1 hr of reperfusion provided significant neuroprotection. We concluded that increased GABA release in preconditioned animals after ischemia might be one of the factors responsible for IPC neuroprotection. Specific activation of GABA B receptor contributes significantly to neuroprotection against ischemia in organotypic hippocampal slices. © 2005 Wiley‐Liss, Inc.

Excitotoxicity

Aminobutyric acid

10.1002/jnr.20674

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Citations (98)

Gering erhöhtes Risiko intrakranieller Blutungen unter SSRI

InFo Neurologie + Psychiatrie (2013)

Christian Lange‐Asschenfeldt

10.1007/s15005-013-0141-3

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Citations (2)

Springer eBooks (2010)

Otto Benkert Ion Anghelescu Christoph Fehr Gerhard Gründer Philip Heiser

10.1007/978-3-642-01910-4_80

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Risiko bei älteren Pflegeheimbewohnern richtet sich nach Substanz und Dosis

InFo Neurologie + Psychiatrie (2012)

Christian Lange‐Asschenfeldt

10.1007/s15005-012-0126-7

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Effect fingerprints of antipsychotic drugs on neural networks in vitro

Journal of Neural Transmission (2019)

Philipp Görtz U. Henning Stephan Theiss Christian Lange‐Asschenfeldt

10.1007/s00702-019-02050-8

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Citations (3)

Springer eBooks (2010)

Otto Benkert Ion Anghelescu Christoph Fehr Gerhard Gründer Philip Heiser

10.1007/978-3-642-01910-4_7

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Citations (0)

Springer eBooks (2010)

Otto Benkert Ion Anghelescu Christoph Fehr Gerhard Gründer Philip Heiser

10.1007/978-3-642-01910-4_12

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Gibt es Unterschiede zwischen den Wirkstoffen?

InFo Neurologie + Psychiatrie (2015)

Christian Lange‐Asschenfeldt

10.1007/s15005-015-1271-6

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Durch Medikamente ausgelöste psychische Erkrankungen

Springer eBooks (2008)

Christian Lange‐Asschenfeldt Wilhelm Niebling

10.1007/978-3-540-71145-2_9

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Citations (1)

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