РА

Р. А. Полтавцева

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

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ГТ

Г. Т. Сухих

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

M. A. Aleksandrova

Koltzov Institute of Developmental Biology

E. V. Svirshchevskaya

Institute of Bioorganic Chemistry

ОВ

О. В. Подгорный

Institute of Bioorganic Chemistry

A. V. Revishchin

Institute of Higher Nervous Activity and Neurophysiology

L. I. Korochkin

Russian Academy of Sciences

ИГ

И. Г. Панова

Koltzov Institute of Developmental Biology

НВ

Н. В. Бобкова

Sechenov University

СВ

С. В. Павлович

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

M. V. Marei

Evangelische Stiftung Volmarstein

Cooperative Institutions

Russian Academy of Sciences

132

Ministry of Health of the Russian Federation

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Lomonosov Moscow State University

Koltzov Institute of Developmental Biology

Academy of Medical Sciences

Sechenov University

Institute of Theoretical and Experimental Biophysics

Pirogov Russian National Research Medical University

Institute of Bioorganic Chemistry

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Ultrastructural and Immunohistochemical Features of Telocytes in Placental Villi in Preeclampsia

Scientific Reports (2018)

N. V. Nizyaeva Т. V. Sukhacheva Р. А. Серов Galina V. Kulikova М. N. Nagovitsyna

A new cell type, interstitial Cajal-like cell (ICLC), was recently described in different organs. The name was recently changed to telocytes (TCs), and their typical thin, long processes have been named telopodes (Tp). TCs regulate the contractile activity of smooth muscle cells and play a role in regulating vessel contractions. Although the placenta is not an innervated organ, we believe that TCs are present in the placenta. We studied placenta samples from physiological pregnancies and in different variants of preeclampsia (PE). We examined these samples using light microscopy of semi-thin sections, transmission electron microscopy, and immunohistochemistry. Immunohistochemical examination was performed with primary antibodies to CD34, CD117, SMA, and vimentin, and TMEM16a (DOG-1), the latter was used for the diagnosis of gastrointestinal stromal tumours (GIST) consisting of TCs. We have identified a heterogenetic population of ТСs in term placentas, as these cell types differed in their localization, immunophenotype and ultrastructural characteristics. We assume TMEM16a could be used as the marker for identification of TCs. In PE we have revealed telocyte-like cells with ultrastructural signs of fibrocytes (significant process thickening and the granular endoplasmic reticulum content was increased) and a loss of TMEM16a immunohistochemical staining.

CD117

Fibrocyte

Immunophenotyping

10.1038/s41598-018-21492-w

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Citations (18)

Immune status and cytokine spectrum as predictive signs of the severity of the disease and the effectiveness of intensive care in patients with coronavirus infection COVID-19

Reviews on Clinical Pharmacology and Drug Therapy (2023)

Valentin F. Sadykov Р. А. Полтавцева A. V. Chaplygina Н. В. Бобкова

The pandemic caused by a new strain of SARS-CоV-2 coronavirus has swept the whole world, however, despite the developed strategic directions for the treatment of coronavirus infection and intensive research in all countries, effective methods for treating this severe pathology have not yet been created. The list of drugs against COVID-19 practically does not use compounds that affect the renin-angiotensin system, in the functioning of which the ACE2 coronavirus binding receptor plays a central role. It is assumed that the virus, causing a decrease in the density of ACE2 receptors, leads to disruption of RAS activity. This review presents current research on the response of the immune system to infection with the SARS-CoV-2 virus, describes adaptive and innate cellular mechanisms, and describes a number of predictors of severe COVID-19. To write this review, a search was made in the PubMed database and the scientific electronic library eLibrary.ru. The selection of articles was carried out manually with the main goal of synthesizing data and describing the mechanisms of influence of SARS-CoV-2 on the renin-angiotensin system, and, as a result, on the activation of the adaptive and innate immune response. This review includes 53 publications, including methodological recommendations of the Ministry of Health of the Russian Federation, data from ongoing clinical trials and patents. Data from selected scientific sources were structured and visualized.

Cytokine Storm

Coronavirus

Pandemic

Christian ministry

10.17816/rcf109220

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Citations (1)

THE EFFECT OF YB-1 PROTEIN IN СHIMERIC MODEL OF ALZHEIMER’S DISEASE

Н. В. Бобкова Р. А. Полтавцева Daria Jurievna Zhdanova Vladimir Igorevich Kovalev Alina Vadimovna Chaplygina

The paper focuses on the molecular cell interaction of human mesenchymal stromal cells with the hippocampal primary culture of transgenic XFAD mice and the effect of multifunctional YB-1 protein on the memory and state of adult neurogenesis niches in animals with a chi-meric model of Alzheimer's disease. The results suggest the usefulness of a comprehensive use of cell therapy in combination with YB-1 to activate compensatory mechanisms in patients with Alzheimer's disease.

10.47501/978-5-6044060-1-4.10

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[Neural stem and progenitor cells of human embryos and fetuses as a basis of biomedical new technologies].

PubMed (2003)

Р. А. Полтавцева A. V. Revishchin M. A. Aleksandrova L. I. Korochkin И. В. Викторов

Isolation and cultivation of stem and progenitor cells of human embryos and fetuses at the age of 7-12 weeks of gestation have been described. The embryonic cells of human brain formed neurospheres with heterogenous composition. Cell differentiation took place not only in the presence of serum or as a result of attachment of neurosphere to a sublayer, but also in floating neurospheres in the presence of mitogens. In most neurospheres, the nestin-immunopositive cells were located near the surface while the cells stained for beta-tubulin III and glial fibrillar acid protein, as compact groups inside the neurospheres.

Neurosphere

Nestin

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Citations (13)

Effect of Conversion Cocktail on Astrocyte and Neuronal Status in the Primary Hippocampal Culture of 5xFAD Mice with Angiotensin-Converting Enzyme 2 Inhibition

Journal of Evolutionary Biochemistry and Physiology (2024)

A. V. Chaplygina D. Yu. Zhdanova Р. А. Полтавцева N. V. Bobkova

Primary culture

Primary (astronomy)

10.1134/s0022093024060310

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Proliferation of Peripheral Blood Lymphocytes and Mesenchymal Stromal Cells Derived from Wharton’s Jelly in Mixed and Membrane-Separated Cultures

Bulletin of Experimental Biology and Medicine (2017)

A. M. Poltavtsev Р. А. Полтавцева M. N. Yushina С. В. Павлович E. V. Svirshchevskaya

Wharton's jelly

10.1007/s10517-017-3846-3

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Citations (2)

Activation of NK Cells in Mixed Cultures of Wharton’s Jelly Mesenchymal Stromal Cells and Peripheral Blood Lymphocytes

Bulletin of Experimental Biology and Medicine (2018)

E. V. Svirshchevskaya A. M. Poltavtsev G. Zh. Os’mak Р. А. Полтавцева

Wharton's jelly

10.1007/s10517-018-3985-1

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Citations (2)

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

International Journal of Molecular Sciences (2022)

E. V. Svirshchevskaya Nina V. Sharonova Р. А. Полтавцева M. V. Konovalova А. Е. Efimov

Multiple studies have demonstrated that various nanoparticles (NPs) stimulate osteogenic differentiation of mesenchymal stem cells (MSCs) and inhibit adipogenic ones. The mechanisms of these effects are not determined. The aim of this paper was to estimate Wharton's Jelly MSCs phenotype and humoral factor production during tri-lineage differentiation per se and in the presence of silicon-gold NPs. Silicon (SiNPs), gold (AuNPs), and 10% Au-doped Si nanoparticles (SiAuNPs) were synthesized by laser ablation, characterized, and studied in MSC cultures before and during differentiation. Humoral factor production (n = 41) was analyzed by Luminex technology. NPs were nontoxic, did not induce ROS production, and stimulated G-CSF, GM-CSF, VEGF, CXCL1 (GRO) production in four day MSC cultures. During MSC differentiation, all NPs stimulated CD13 and CD90 expression in osteogenic cultures. MSC differentiation resulted in a decrease in multiple humoral factor production to day 14 of incubation. NPs did not significantly affect the production in chondrogenic cultures and stimulated it in both osteogenic and adipogenic ones. The major difference in the protein production between osteogenic and adipogenic MSC cultures in the presence of NPs was VEGF level, which was unaffected in osteogenic cells and 4-9 times increased in adipogenic ones. The effects of NPs decreased in a row AuNPs > SiAuNPs > SiNPs. Taken collectively, high expression of CD13 and CD90 by MSCs and critical level of VEGF production can, at least, partially explain the stimulatory effect of NPs on MSC osteogenic differentiation.

CD90

Wharton's jelly

Chondrogenesis

10.3390/ijms23042134

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Citations (1)

Isolation and characterization of trophoblasts from enzymatic explants of human term placenta

Human Cell (2017)

T.D. Kolokoltsova И. Н. Сабурина И.М. Зурина А.А. Горкун Nastasia V. Kosheleva

Isolation

Trophoblast

10.1007/s13577-017-0174-x