Esteban Arrieta‐Bolaños

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Citations (4)

Combined Analysis of Early CD4+ T Cell Counts and CMV Serostatus May Improve CMV Risk Assessment after Allogeneic Hematopoietic Cell Transplantation

Cells (2021)

Saskia Leserer Esteban Arrieta‐Bolaños Ulrike Buttkereit Dietrich W. Beelen Amin T. Turki

The incidence and severity of viral complications after cellular therapy are highly variable. Recent publications describe relevant interactions between the human Cytomegalovirus (CMV) and host immunity in recipients of allogeneic hematopoietic cell transplantation (HCT). Although immune monitoring is routinely performed in HCT patients, validated cut-off levels correlating with transplant outcomes such as survival or CMV reactivation are mostly limited to day +100, which is later than the median time for CMV reactivation in the absence of medical prophylaxis. To address this gap in early risk assessment, we applied an unsupervised machine learning technique based on clustering of day +30 CD4+ helper T cell count data, and identified relevant cut-off levels within the diverse spectrum of early CD4+ reconstitution. These clusters were stratified for CMV recipient serostatus to identify early risk groups that predict clinical HCT outcome. Indeed, the new risk groups predicted subsequent clinical events such as NRM, OS, and high CMV peak titers better than the most established predictor, i.e., the positive CMV recipient serostatus (R+). More specifically, patients from the R+/low CD4+ subgroup strongly associated with high CMV peak titers and increased 3-year NRM (subdistribution hazard ratio (SHR) 10.1, 95% CI 1.38–73.8, p = 0.023), while patients from the R-/very high CD4+ subgroup showed comparable NRM risks (SHR 9.57, 95% CI 1.12–81.9, p = 0.039) without such an association. In short, our study established novel cut-off levels for early CD4+ T cells via unsupervised learning and supports the integration of host cellular immunity into clinical risk-assessment after HCT in the context of CMV reactivation.

Serostatus

10.3390/cells10123318

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Citations (3)

Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima

Human Immunology (2019)

Rodrigo Barquera Diana Iraíz Hernández-Zaragoza Francia Paulina Arellano-Prado Isis Goné-Vázquez Stephen Clayton

10.1016/j.humimm.2019.06.004

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Genetic diversity of HLA system in a population sample from Aguascalientes, Mexico

Human Immunology (2019)

Alicia Bravo-Acevedo Rodrigo Barquera Esteban Arrieta‐Bolaños Diana Iraíz Hernández-Zaragoza Stephen Clayton

Linkage Disequilibrium

Disequilibrium

10.1016/j.humimm.2019.05.016

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Genetic diversity of HLA system in two populations from Campeche, Mexico: Campeche city and rural Campeche

Human Immunology (2019)

Rodrigo Barquera Julio Lara‐Riegos Komathi Sree Ponnandai-Shanmugavel Alexander Immel Esteban Arrieta‐Bolaños

10.1016/j.humimm.2019.07.281

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Citations (2)

Pharmacogenetics: toward the individualization of pharmacologic therapy in Costa Rica

Acta Médica Costarricense (2012)

Esteban Arrieta‐Bolaños Pablo Alvarado-Ulate Olga Baudrit-Carrillo Lizbeth Salazar‐Sánchez

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The most frequent HLA alleles around the world: A fundamental synopsis

Best Practice & Research Clinical Haematology (2024)

Alicia Sanchez‐Mazas José Manuel Nunes Da Di E. Dominguez Pascale Gerbault

A comprehensive knowledge of human leukocyte antigen (HLA) molecular variation worldwide is essential in human population genetics research and disease association studies and is also indispensable for clinical applications such as allogeneic hematopoietic cell transplantation, where ensuring HLA compatibility between donors and recipients is paramount. Enormous progress has been made in this field thanks to several decades of HLA population studies allowing the development of helpful databases and bioinformatics tools. However, it is still difficult to appraise the global HLA population diversity in a synthetic way. We thus introduce here a novel approach, based on approximately 2000 data sets, to assess this complexity by providing a fundamental synopsis of the most frequent HLA alleles observed in different regions of the world. This new knowledge will be useful not only as a fundamental reference for basic research, but also as an efficient guide for clinicians working in the field of transplantation.

10.1016/j.beha.2024.101559

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Citations (5)

Genetic diversity of HLA system in two populations from Tlaxcala, Mexico: Tlaxcala city and rural Tlaxcala

Human Immunology (2019)

María de los Ángeles Pavón-Vargas Michael H. Crawford Rodrigo Barquera Concepción López-Gil Esteban Arrieta‐Bolaños

10.1016/j.humimm.2019.07.282

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Citations (18)

5-Locus high-resolution HLA allele and haplotype frequencies in Costa Ricans from the Central Valley

Human Immunology (2019)

Esteban Arrieta‐Bolaños Juan José Madrigal-Sánchez Jeremy E. Stein Priscilla Órlich-Pérez Gilbert Arrieta-Molina