Romana Dmitrović

Foundation for Reproductive Medicine

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D Drndarević

Arheološki Institut

Branislav Lako

University of Novi Sad

Richard S. Legro

Penn State Milton S. Hershey Medical Center

D. Djordjevic

University of Belgrade

N Stajković

Military Medical Academy

M Obradović

University of Belgrade

Djerković

Allen R. Kunselman

Pennsylvania State University

Mihajlo Strelec

University Hospital Centre Zagreb

Sanja Vujisić

Klinička bolnica "Sveti Duh"

Cooperative Institutions

University of Zagreb

University of Belgrade

University Hospital Centre Zagreb

Centar za Promociju Nauke

Univerzitetski Klinički Centar Srbije

Klinička bolnica "Sveti Duh"

Children's Hospital Zagreb

Klinička bolnica Merkur

Pennsylvania State University

Penn State Milton S. Hershey Medical Center

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Polycystic Ovary Syndrome

Humana Press eBooks (2007)

Romana Dmitrović Richard S. Legro

Polycystic ovary syndrome (PCOS) is a common but poorly understood endocrinopathy diagnosed by the combination of oligomenorrhea, hyperandrogenism, and polycystic ovaries. Many of the women with PCOS are also uniquely and variably insulin-resistant. This can manifest as hyperinsulinemia, glucose intolerance, and frank diabetes. Affected women are plagued by infertility, menstrual disorders, dysfunctional uterine bleeding, and peripheral skin disorders including acne and hirsutism. The etiology of the syndrome is poorly understood. Many, if not most, US women with PCOS are also obese, which exacerbates many of the symptoms of the syndrome. This suggests that lifestyle interventions should be the first line treatment for these obese women. Treatment tends to be symptom-based, although some treatments can address multiple presenting complaints. The two most commonly used medications for chronic treatment, oral contraceptives and insulin sensitizing, do appear to improve multiple aspects of the syndrome simultaneously. Unfortunately, clinical trials have focused primarily on surrogate measures rather than clinical outcomes.

Hyperandrogenism

hirsutism

Hyperinsulinemia

Dysfunctional uterine bleeding

Anovulation

Etiology

10.1007/978-1-59745-400-1_11

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Citations (7)

Heterotropic Pregnancy and Hemorrhagic Shock Following Embryo Transfer of Cryopreserved-Thawed Blastocysts with Successful Outcome

Journal of Fertilization In Vitro - IVF-Worldwide Reproductive Medicine Genetics & Stem Cell Biology (2013)

Erceg Ivkosic Romana Dmitrović Sanja Vujisić

Heterotopic Pregnancy (HP) is a very rare entity, but due to the use of In Vitro Fertilization (IVF) techniques it is now a common complication of IVF. However, there are no literature reports of HP when a Frozen-Thawed Embryotransfer (FET) of blastocysts is performed. In stimulated cycles, one or two embryos are replaced usually on days 3-5 after follicular aspiration and the rest are frozen for future FET attempts. This adds much to the cumulative pregnancy rate for the particular cycle, especially if the frozen embryos are blastocysts. However, there are no reports of HP with FET of blastocysts, although HP with FET of 3 day embryos has been previously reported. We report a case of a 35-year old patient, 7-weeks pregnant after the FET of two thawed blastocysts, who presented into the emergency room in a state of a hemorrhagic shock, with no vaginal bleeding. At her previous exam, at 5+3 weeks of pregnancy, one gestational sac in the uterus was visualized. At admission, Transvaginal Ultrasound (TVU) revealed an adnexal mass on the right side of the lower abdomen, an abdominal cavity filled with large amount of free fluid, and a two-millimeter embryo with a positive heart rate in the uterus. An emergency laparotomy and right salpingectomy were performed, and HP was confirmed. The intrauterine pregnancy continued without any complications, and resulted in a vaginal delivery of a live-born child, at full term. Caution should be exerted when two cryopreserved and thawed blastocysts are transferred, because there is the possibility of a HP.

Hemorrhagic shock

10.4172/2375-4508.1000113

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Severity of symptoms in primary dysmenorrhea—a doppler study

European Journal of Obstetrics & Gynecology and Reproductive Biology (2003)

Romana Dmitrović Branimir Peter Andrea Cvitković-Kuzmić Mihajlo Strelec Tibor Kereshi

Doppler ultrasound

10.1016/s0301-2115(02)00372-x

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Citations (31)

P139Transvaginal color Doppler study of uterine blood flow in primary dysmenorrhea

Ultrasound in Obstetrics and Gynecology (2000)

Romana Dmitrović

Background The pain in primary dysmenorrhea is caused by excessive prostaglandin production that leads to vasoconstriction and uterine ischemia. Changes in uterine blood flow are important factor in patophysiology of primary dysmenorrhea. The aim of the study was to determine if vasoconstriction of the uterine vessels in patients with primary dysmenorrhea is detectable by transvaginal color Doppler ultrasound. Methods Forty‐two women with primary dysmenorrhea and 50 healthy controls were included in this prospective study. Women were examined with transvaginal color Doppler ultrasound on first day of the cycle, once in the follicular and once in the luteal phase. Measurements of pulsatility index in uterine, arcuate, radial and spiral arteries were performed. Student's t ‐test was used to establish statistical significance between groups. Results Women in dysmenorrhea group had significantly higher uterine blood flow indices than healthy controls in all three measurements periods. This includes all vessels studied on the first day of the cycle, the radial and spiral arteries during the follicular phase and the arcuate, radial and spiral arteries during the luteal phase. Conclusions We found that women with primary dysmenorrhea have elevated Doppler indices in uterine arteries not only on first day of the cycle but throughout the whole cycle. Therefore we postulated that primary dysmenorrhea is not only the disorder of menstruation but also a disease of a menstrual cycle in whole.

Menstruation

Spiral artery

10.1046/j.1469-0705.2000.00004-1-138.x

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IZVANMATERNIČNA TRUDNOĆA U ŽENE KORISNICE ORALNE HORMONSKE KONTRACEPCIJE

Gynaecologia et perinatologia (2006)

Boris Lovrić Željko Lasović Zvonko Šoljić Marijan Jukić Romana Dmitrović

Ene reaction

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[Clinical picture of cardioborreliosis: from AV block to perimyocarditis].

PubMed (1993)

Z. Vasiljević B. Vujisic Romana Dmitrović Boris Reljić J Smiljanić

The third degree A-V heart block with severe Adams-Stokes attacks in nine patients with Lyme borreliosis was described. All patients had similar clinical picture: previously healthy with syncope as abrupt onset of the disease. Data on skin changes--erythema migrans--were obtained subsequently although the patients did not recall being bitten by a tick. Diagnosis was based on clinical manifestation, and on positive serologic tests to Borrelia. After the administered therapy (on admission atropine 0.5 mg i.v., and/or isoproterenol 0.02 mcg/kg/min, temporary pace-maker in two patients; and after proved diagnosis penicillin 20 mil. unit per day 10 days, and tetracyclin 2.0 gr per day 20 days A-V block returned to sinus rhythm with normal A-V conduction, and all biochemical parameters returned to normal limits. Perimyocarditis is not rare during Lyme borreliosis, but in this case infection syndrome is dominant.

Erythema

Normal Sinus Rhythm

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Citations (3)

[Ixodes ricinus proven as a vector of Lyme borreliosis in Yugoslavia].

PubMed (1992)

D Drndarević Branislav Lako R Stojanović N Stajković M Obradović

263 fasting female Ixodes ricinus were examined for Borrelia burgorferi, the vector of Lyme borreliosis. Female ticks were collected by flagella in the biotopes (Belgrade and Osijek) in which ticks bite patients with Lyme borreliosis. Borrelia burgorferi was proved in 58 (22%) of 263 female ticks in the native preparations of the intestinal contents by darkfield microscopy. In macerates of two groups of 5 female ticks each, Borrelia burgorferi was isolated by cultivation in the modified Kelly nutrient media for borrelia. The supposition that Ixodes ricinus is the vector of Lyme borreliosis in Yugoslavia is confirmed.

Borrelia afzelii

Borrelia garinii

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Citations (2)

Transvaginal color Doppler study of uterine blood flow in primary dysmenorrhea

Acta Obstetricia Et Gynecologica Scandinavica (2000)

Romana Dmitrović

Color doppler

Primary (astronomy)

10.3109/00016340009169273

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