Ilaria Morandini

Santa Maria Nuova Hospital

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Marta Filidei

Santa Maria Nuova Hospital

Martina Proietti Checchi

Bambino Gesù Children's Hospital

Roberto Paparella

Sapienza University of Rome

Giorgia Sforza

Bambino Gesù Children's Hospital

Danilo Costanti

Santa Maria Nuova Hospital

Samuela Tarantino

Bambino Gesù Children's Hospital

Giovanna Viticchi

Marche Polytechnic University

Federico Vigevano

Istituti di Ricovero e Cura a Carattere Scientifico

Romina Moavero

Istituti di Ricovero e Cura a Carattere Scientifico

Massimiliano Valeriani

Bambino Gesù Children's Hospital

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Istituti di Ricovero e Cura a Carattere Scientifico

Bambino Gesù Children's Hospital

Santa Maria Nuova Hospital

Sapienza University of Rome

University of Rome Tor Vergata

Azienda Ospedaliera S.Maria

University of Perugia

King's College London

Guy's and St Thomas' NHS Foundation Trust

Evelina London Children's Healthcare

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The Role of Transcranial-Color-Doppler in the Management of Basilar Artery Stenosis: Case Series and Systematic Review of Literature

Journal of Experimental Neurology (2024)

Marta Filidei Chiara Di Schino Massimiliano Allegritti Danilo Costanti Ilaria Morandini

Managing vertebrobasilar (VB) stroke, particularly basilar artery occlusion (BAO), presents challenges due to diverse clinical presentations and intricate diagnostics, risking delays in acute-phase reperfusion therapies. The diagnostic complexities of VB stroke prompt questions about whether presentation tempo influences outcomes. For non-urgent cases of basilar artery stenosis (BAS) lacking guidelines, clinical management becomes case-dependent. Current options include aggressive medical therapy (AMT) and percutaneous transluminal angioplasty and/or stenting (PTAS). However, the choice of PTAS remains debated, with recent trials observing higher-than-expected recurrence rates, particularly in intracranial stenosis. Understanding hemodynamic status is crucial in predicting stroke risk, especially in atherosclerotic VB disease. Recent studies highlighted the role of distal flow status in predicting stroke risk, emphasizing the importance of hemodynamic assessment beyond anatomic measures. Neurosonology, especially transcranial color-coded duplex sonography (TCCS), emerges as a valuable tool for assessing hemodynamics. Despite TCCS being operator-dependent and technically challenging for BAS evaluation, it effectively detects significant hemodynamic changes, providing real-time information on collateral flow. This review explores the potential role of TCCS in managing BA hemodynamic failure in VB stroke, with particular regard to the selection of BAS patients who may benefit from PTAS.

Transcranial Doppler

Color doppler

10.33696/neurol.5.090

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Pediatric Neuromyelitis Optica Spectrum Disorder: Case Series and Literature Review

Life (2021)

Michela Ada Noris Ferilli Roberto Paparella Ilaria Morandini Laura Papetti Lorenzo Figà Talamanca

Neuromyelitis Optica Spectrum Disorder (NMOSD) is a central nervous system (CNS) inflammatory demyelinating disease characterized by recurrent inflammatory events that primarily involve optic nerves and the spinal cord, but also affect other regions of the CNS, including hypothalamus, area postrema and periaqueductal gray matter. The aquaporin-4 antibody (AQP4-IgG) is specific for NMOSD. Recently, myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) have been found in a group of AQP4-IgG negative patients. NMOSD is rare among children and adolescents, but early diagnosis is important to start adequate therapy. In this report, we present cases of seven pediatric patients with NMOSD and we review the clinical and neuroimaging characteristics, diagnosis, and treatment of NMOSD in children.

Neuromyelitis Optica

Myelin oligodendrocyte glycoprotein

Spectrum disorder

Demyelinating Disorder

Optic neuritis

10.3390/life12010019

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Citations (12)