Xu Zhu

Xuzhou Medical College

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Shunsuke Chiba

Nanyang Technological University

Pei Xu

Xuzhou Medical College

Yi‐Feng Wang

University of Science and Technology of China

Dong Guo

Xuzhou Medical College

Jun Lin

National Yang Ming Chiao Tung University

Feng‐Lian Zhang

University of Science and Technology of China

Xiaoping Xu

Soochow University

Hui-Xian Jiang

Xuzhou Medical College

Tian-Zi Hao

Xuzhou Medical College

Mingqiang Xue

Soochow University

Cooperative Institutions

Xuzhou Medical College

Soochow University

First Affiliated Hospital of Soochow University

Chinese Academy of Sciences

Zhejiang University

Shanghai Jiao Tong University

Fudan University

Chinese Academy of Medical Sciences & Peking Union Medical College

First Affiliated Hospital of Zhengzhou University

Tianjin Medical University

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CXCL13 inhibits microRNA-23a through PI3K/AKT signaling pathway in adipose tissue derived-mesenchymal stem cells

Biomedicine & Pharmacotherapy (2016)

Zhenwei Li Liang Zhao Qicai Han Xu Zhu

RUNX2

CXCL13

10.1016/j.biopha.2016.07.059

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Citations (6)

In vitro study of biocompatibility of a wrapped-core structure composite scaffold for bone tissue engineering

Zhonghua shiyan waike zazhi (2013)

Chuangjian Wang Xue-jian Wu Xu Zhu Ying Li Chunlin Zhang

Objective To assess whether a wrapped-core structure composite scaffold possesses the biocompatibility in vitro.Methods The wrapped-core structure composite scaffold composed of poly lactic-co-glycolic acid (PLGA)/β-TCP skeleton wrapped with type Ⅰ collagen was manufactured via LDM,and PLGA/β-TCP scaffold was chosen as the control group.SEM was used to study morphology of bone marrow mesenchymal stem cells (BMSCs) on the surface of the original scaffolds.Hydrophilicity was estimated by water absorption ratio.Cell proliferation was estimated by methyl thiazol tetrazolium (MTT) assay and the osteogenic differentiation of BMSCs was estimated by alkaline phosphatase (ALP).Results The water absorption of the original scaffold [(18.1 ± 0.4) ％] was significantly higher (P ＜ 0.01) than that of the control group [(2.6 ±0.3)％].After co-culture of BMSCs for 6,10,and 14 days,the A values of original scaffolds and control groups were 0.28 ± 0.09,0.60 ± 0.10,0.76 ± 0.10,and 0.19 ± 0.09,0.36 ±0.05,0.46 ± 0.12,respectively; the activities of ALP were 124.33 ± 14.22,189.00 ± 19.52,230.00 ± 12.12,and 78.33 ± 8.02,105.67 ± 7.77,123.67 ± 20.84,respectively.There was significant difference between the two groups (P ＜ 0.05).Conclusion The wrapped-core structure composite scaffold possesses admirable biocompatibility and is expected to be of useful value in bone tissue engineering. Key words: Bone tissue engineering; Scaffold; Biocompatibility

Biocompatibility

PLGA

MTT assay

10.3760/cma.j.issn.1001-9030.2013.07.002

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Does fixation of both clavicle and scapula is better than clavicle alone in surgical treatment of floating shoulder injury? A retrospective study

Research Square (Research Square) (2022)

Yijie Shao Xu Zhu Bo Liu Chenchen Ji Guangdong Chen

Abstract Background : Little research was available to explore which surgical fixation was better between fixation of both clavicle and scapula and clavicle alone in management of floating shoulder injury. Methods : Total 69 patients with floating shoulder injury receiving surgery from February 2005 to July 2020 participated in the study. 49 patients underwent fixation of the clavicle alone (Group C) while 20 patients underwent fixation of both clavicle and scapula (Group C+S). They were further divided into subgroups according to age: Group C1, Group C+S1 (age≤55 years old) and Group C2, Group C+S2 (age＞55 years old). The radiological parameter (glenopolar angle (GPA)) and clinical outcomes (Herscovici score, Constant-Murley shoulder outcome score (CSS score), and Visual Analogue Scale score (VAS score)) were collected and compared between these groups. The correlation between age and radiological parameter and clinical outcomes were calculated by the Spearman correlation analysis. Results : All people were followed up for at least 1 year. The degree of change in GPA before and after surgery in Group C+S is significantly better than that in Group C. The Herscovici and CSS score in Group C+S2 were significantly higher than those in Group C2 at 1 month, 3 months and 1 year after surgery. However, no significant difference in Herscovici and CSS score was found at final follow-up (1 year after surgery) between Group C+S1 and Group C1. The VAS score in Group C+S2 at final follow-up was significantly lower than that in Group C2. No significant difference in VAS score at final follow-up was found between Group C+S1 and Group C1. In addition, the VAS score was negatively correlated with Herscovici and CSS score. No correlation was found between VAS score and GPA. Conclusions : Both types of surgical fixation are effective in management of floating shoulder injury. For young people with floating shoulder injury, both types of surgical fixation are equally effective. However, for older people with floating shoulder injury, fixation of both clavicle and scapula is better in prognosis than fixation of clavicle alone.

10.21203/rs.3.rs-1611855/v2

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Methylprednisolone on cultured Schwann cells secrete nerve growth factor research

Central Plains Medical Journal (2009)

Xu Zhu Xuejian Wu

Objective To study the methylprednisolone on cultured Schwann cells secrete nerve growth factor to promote the role. Methods The purified Schwann cells match single - cell suspension, according to a 5 × 104/hole against the number of cells in the pre - shop gelatin over the 4 - hole plate in training. According to the accession to the concentration of the drug was divided into four groups: A group, control group; B group, adding 0.1 mg / L methylprednisolone; C group, adding 1.0 mg/ L methylprednisolone ; D group, to join 5.0 mg/ L methylprednisolone. Dosing in the first 2,4,6,8,10 d learned to do medium NGF, CNTF, GDNF quantitative analysis. Results B, C, D groups Schwann cells faster than the growth rate of group A, three kinds of nerve growth factor secreted significantly more than group A, statistically significant differences (P 0.05). Conclusions Methylprednisolone can promote the in vitro proliferation of Schwann cells and nerve growth factor secretion. Application of low - dose and high dose had no significant differences in the application. Key words: Methylprednisolone ; Schwann cells; Nerve growth factor

Schwann cell

Ciliary neurotrophic factor

10.3760/cma.j.issn.1674-4756.2009.10.021

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Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3

Military Medical Research (2022)

Qin Zhang Fang-Xing Yu Yanglin Wu Chengyuan Yang Naicheng Liu

Adeno-associated virus

10.1186/s40779-022-00393-0

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Citations (7)

ChemInform Abstract: Catalytic Asymmetric Aza‐ene Reaction of 3‐Indolylmethanols with Cyclic Enaminones: Enantioselective Approach to C3‐Functionalized Indoles.

ChemInform (2014)

Wei Tan Bai‐Xiang Du Xin Li Xu Zhu Feng Shi

Ene reaction

10.1002/chin.201445115

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Synthesis of Vitisin A & D: Thermal Isomerization Enabled by a Persistent Radical Equilibrium

Kevin Romero Mitchell H. Keylor Markus Grießer Xu Zhu Ethan Strobel

The total synthesis of oligomer natural products derived from resveratrol has been achieved through a putative biogenetic bond migration from a presumed common intermediate in a divergent biosynthetic pathway.

10.26434/chemrxiv.10294826.v1

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Ultrasound irradiation promoted catalyst-free construction of formamidine framework using isocyanide as building blocks

Tetrahedron Letters (2011)

Tong‐Hao Zhu Xu Zhu Xiaoping Xu Tao Chen Shun‐Jun Ji

10.1016/j.tetlet.2011.03.100

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Citations (14)

ChemInform Abstract: Nucleophilic Substitution of Ferrocenyl Alcohols by Cerium Ammonium Nitrate: C—N, C—S, and C—O Bonds Formation.

ChemInform (2010)

Ran Jiang Ying Zhang Yechen Shen Xu Zhu Xiaoping Xu

Abstract Ferrocenyl alcohols undergo nucleophilic substitution reactions to give the arylamine, thioether, and ether products (III), (V), and (VII) in moderate to good yields.

Ammonium nitrate

Substitution reaction

Substitution (logic)

10.1002/chin.201041181

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A bis-dianionic β-ketoiminato octalithium complex as a universal catalyst for hydroboration with broad scope

New Journal of Chemistry (2023)

Yu Zheng Xu Zhu Xiaojuan Xu Shuai Zhou Wenguang Lu

A bis-dianionic β-ketoiminato octalithium complex can serve as a universal catalyst for the hydroboration of a wide array of unsaturated compounds including esters, aldehydes, ketones, imines, nitriles, carbonates, and amides.

Hydroboration

Scope (computer science)

10.1039/d3nj03524g

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