Tulika Dey

Banaras Hindu University

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Surendra Pratap Mishra

Banaras Hindu University

Donat‐Peter Häder

Friedrich-Alexander-Universität Erlangen-Nürnberg

A. Vaishampayan

Banaras Hindu University

Kulsoom Zahra

Banaras Hindu University

Uma Pandey

Banaras Hindu University

A. L. J. Rao

Punjabi University

Rajni Sinha

Banaras Hindu University

Kulsoom Zahra

Banaras Hindu University

Parmeswarappa Shivappa Byadgi

Banaras Hindu University

Ashish

Institute of Microbial Technology

Cooperative Institutions

Banaras Hindu University

Institute of Medical Sciences

Friedrich-Alexander-Universität Erlangen-Nürnberg

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Schiller International University

Michigan State University

Punjabi University

Government Medical College

Forschungsinstitut für Anwendungsorientierte Wissensverarbeitung

Japan Science and Technology Agency

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A study of oxidative stress in cervical cancer- an institutional study

Biochemistry and Biophysics Reports (2020)

Kulsoom Zahra Sandeep Patel Tulika Dey Uma Pandey Surendra Pratap Mishra

Cervical cancer is the second most common cause of cancer-related death among women worldwide, especially in developing countries. Oxidative stress has been associated with cervical cancer. Many studies demonstrated that the low level of antioxidants induces the production of free radicals that cause lipid peroxidation, DNA, and protein damage leading to mutations that favors malignant transformation. This is a case-control institutional study conducted to evaluate the level of oxidative stress in cervical cancer patients and the age-matched healthy controls. We measured level of TBARS expressed as MDA, activity of SOD and GSH level by the spectrophotometric method, and level of 8-OHdG was estimated using a competitive sandwich ELISA assay. Our results showed a significant increase in the level of lipid peroxidation in group IV when compared to the control, group II and group III (p < 0.001). The activity of SOD was also significantly higher in group IV when compared to the control group (p < 0.001), group II (p < 0.001), and group III (p < 0.001). The level of GSH was also significantly lower in group IV when compared to the control group (p < 0.01), group II (p < 0.01), and group III (p < 0.01). The level of 8-OHdG was significantly higher in group IV than in the other groups (p < 0.01). The results suggest that oxidative stress is involved in the pathogenesis of cervical cancer, which is demonstrated by an increased level of lipid peroxidation and higher levels of 8-OHdG and an altered antioxidant defense system.

TBARS

Pathogenesis

10.1016/j.bbrep.2020.100881

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Citations (34)

An Insight into the Conventional and Ayurvedic Therapies for the Treatment of Parkinson's Disease

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2022)

Tulika Dey Kulsoom Zahra Parmeswarappa Shivappa Byadgi Anup Singh Surendra Pratap Mishra

10.7860/jcdr/2022/51177.15883

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Citations (0)

Successful rice cultivation with genetically manipulated thermo-tolerant Azolla as a bio-N fertilizer

Acta Hydrobiologica (1998)

A. Vaishampayan Tulika Dey Rajni Sinha Donat‐Peter Häder

Azolla

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Citations (3)

Research Trends of Coronavirus: Bibliometric Analysis from 1989-2019

DOAJ (DOAJ: Directory of Open Access Journals) (2021)

Shiv P. Singh Sanjay Kataria Tulika Dey

Coronavirus

2019-20 coronavirus outbreak

Pandemic

10.5865/ijkct.2021.11.4.101

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Citations (1)

Cyanobacterial biofertilizers in rice agriculture

The Botanical Review (2001)

A. Vaishampayan Rajeshwar P. Sinha Donat‐Peter Häder Tulika Dey Akansha Gupta

Biofertilizer

Azolla

10.1007/bf02857893

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Citations (242)

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Frontiers in Oncology (2020)

Kulsoom Zahra Tulika Dey Ashish Surendra Pratap Mishra Uma Pandey

Pyruvate kinase plays a vital role in regulating cell metabolism. It catalyzes the rate-limiting step of glycolysis, the conversion of Phosphoenolpyruvate (PEP) to Pyruvate with concomitant production of ATP. It consists of four isoforms in mammals, which are tissue-specific PKL, PKR, PKM1, and PKM2. PKL, PKR, and PKM1 exist as stable tetramers, whereas PKM2 subunits form tetramers and dimmers. M2 isoform of Pyruvate Kinase (PKM2) is a crucial regulator and has the unique ability to shift glucose metabolism in favor of cancer cells. In accordance, cancerous state is correlated with high PKM2 expression in a variety of tumor tissues. Besides a crucial metabolic role, a significant chunk of data has unraveled the role of PKM2 in gene transcription and its ability to act as protein kinase. Due to the soaring number of papers dealing with the role of PKM2 in tumorigenesis, it has gained enormous attention in recent past. The review deals with the metabolic role of pyruvate kinase M2 in normal cell versus cancerous cells, and its therapeutic relevance and future directions in the field are also discussed.

PKM2

Warburg Effect

10.3389/fonc.2020.00159

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Citations (384)