Linlin Wu

China Jiliang University

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Xiaofeng Ma

Nanjing Forestry University

Ying Fang

University of Illinois Urbana-Champaign

Ximan Bu

Nanjing Tech University

Jing Liu

Guangzhou Medical University

Yifeng Gao

Nanjing Tech University

Duanqing Pei

Westlake University

Junqi Kuang

Westlake University

Jiekai Chen

Chinese Academy of Sciences

Wenjing Diao

Nanjing Tech University

Qiang Wang

China Jiliang University

Cooperative Institutions

Chinese Academy of Sciences

Guangzhou Institutes of Biomedicine and Health

University of Chinese Academy of Sciences

Guangzhou Medical University

Nanjing Tech University

Guangzhou Regenerative Medicine and Health Guangdong Laboratory

Westlake University

Shanghai Jiao Tong University

Guiyang Medical University

University of Science and Technology of China

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Hierarchically ordered mesoporous Co3O4 materials for high performance Li-ion batteries

Scientific Reports (2016)

Shijiao Sun Xiangyu Zhao Meng Yang Linlin Wu Zhaoyin Wen

Abstract Highly ordered mesoporous Co 3 O 4 materials have been prepared via a nanocasting route with three-dimensional KIT-6 and two-dimensional SBA-15 ordered mesoporous silicas as templates and Co(NO 3 ) 2 · 6H 2 O as precursor. Through changing the hydrothermal treating temperature of the silica template, ordered mesoporous Co 3 O 4 materials with hierarchical structures have been developed. The larger pores around 10 nm provide an efficient transport for Li ions, while the smaller pores between 3–5 nm offer large electrochemically active areas. Electrochemical impedance analysis proves that the hierarchical structure contributes to a lower charge transfer resistance in the mesoporous Co 3 O 4 electrode than the mono-sized structure. High reversible capacities around 1141 mAh g −1 of the hierarchically mesoporous Co 3 O 4 materials are obtained, implying their potential applications for high performance Li-ion batteries.

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10.1038/srep19564

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Citations (88)

Comparative absorption kinetics of seven active ingredients of Eucommia ulmoides extracts by intestinal in situ circulatory perfusion in normal and spontaneous hypertensive rats

Biomedical Chromatography (2019)

He-Jia Hu Linlin Wu Mei Li Cun Xue Guangcheng Wang

Abstract Eucommia ulmoides Oliv. ( E. ulmoides ) is a valuable and nourishing medicinal herb in China that has been used in the treatment of hypertension. Given the fact that most traditional Chinese medicine is mainly used to treat disease, investigating the pharmacokinetics of traditional Chinese medicines in the pathological state is more useful than that in the normal state. However, the differences in the absorption kinetics of active ingredients of E. ulmoides extract between pathological and physiological conditions have not been reported. Therefore, in this study, the rat intestinal in situ circulatory perfusion model was used to investigate the differences in absorption kinetics of seven active ingredients of E. ulmoides extract in normal and spontaneously hypertensive rats, namely, genipinic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, (+)‐pinoresinol di‐ O ‐ β ‐ D ‐glucopyranoside and (+)‐pinoresinol 4′‐ O ‐ β ‐ D ‐glucopyranoside. Our results indicate that the pathological state of spontaneous hypertension may change the absorption of active components of E. ulmoides extracts, and these findings may provide a reference for improving the rational use of E. ulmoides in the clinic.

Eucommia ulmoides

Chlorogenic Acid

10.1002/bmc.4714

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Multilayer Double-Sided Microstructured Flexible Iontronic Pressure Sensor with a Record-wide Linear Working Range

ACS Sensors (2021)

Yan Xiao Yu Duan Ning Li Linlin Wu Bo Meng

Wearable electronics, electronic skins, and human–machine interfaces demand flexible sensors with not only high sensitivity but also a wide linear working range. The latter remains a great challenge and has become a big hurdle for some of the key advancements imperative to these fields. Here, we present a flexible capacitive pressure sensor with ultrabroad linear working range and high sensitivity. The dielectric layer of the sensor is composed of multiple layers of double-sided microstructured ionic gel films. The multilayered structure and the gaps between adjacent films with random topography and size enhance the compressibility of the sensor and distribute the stress evenly to each layer, enabling a linear working range from 0.013 to 2063 kPa. Also, the densely distributed protrusive microstructures in the electric double layer contribute to a sensitivity of 9.17 kPa–1 for the entire linear working range. For the first time, a highly sensitive pressure sensor that can measure loading conditions across 6 orders of magnitude is demonstrated. With the consistent and stable performance from a low- to high-measurement range, the proposed pressure sensor can be used in many applications without the need for recalibration to suit different loading scenarios.

10.1021/acssensors.0c02547

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Citations (81)

Exciting World of Plant Cellulose Synthases

In Vitro Cellular & Developmental Biology - Animal (2000)

Chandrashekhar P. Joshi Linlin Wu R.V. Chavli Vincent L. Chiang

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Pt‐Decorated Gold Nanoflares for High‐Fidelity Phototheranostics: Reducing Side‐Effects and Enhancing Cytotoxicity toward Target Cells

Angewandte Chemie International Edition (2024)

Ke Quan Xiaoyuan Li Jiaqi Deng Wei‐Ju Chen Zhen Zou

Abstract Functionalized with the Au−S bond, gold nanoflares have emerged as promising candidates for theranostics. However, the presence of intracellular abundantly biothiols compromises the conventional Au−S bond, leading to the unintended release of cargoes and associated side‐effects on non‐target cells. Additionally, the hypoxic microenvironment in diseased regions limits treatment efficacy, especially in photodynamic therapy. To address these challenges, high‐fidelity photodynamic nanoflares constructed on Pt‐coated gold nanoparticles (Au@Pt PDNF) were communicated to avoid false‐positive therapeutic signals and side‐effects caused by biothiol perturbation. Compared with conventional photodynamic gold nanoflares (AuNP PDNF), the Au@Pt PDNF were selectively activated by cancer biomarkers and exhibited high‐fidelity phototheranostics while reducing side‐effects. Furthermore, the ultrathin Pt‐shell catalysis was confirmed to generate oxygen which alleviated hypoxia‐related photodynamic resistance and enhanced the antitumor effect. This design might open a new venue to advance theranostics performance and is adaptable to other theranostic nanomaterials by simply adding a Pt shell.

10.1002/anie.202402881

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Citations (7)

In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik

Acta Pharmacologica Sinica (2007)

Linlin Wu Xinbo Yang Zheng‐Ming Huang He-Zhi Liu WU Guang-xia

Hyperoside

HBeAg

10.1111/j.1745-7254.2007.00510.x

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Citations (119)

Ultratough and recoverable ionogels based on multiple interpolymer hydrogen bonding as durable electrolytes for flexible solid‐state supercapacitor

Journal of Applied Polymer Science (2020)

Yongxin Ge Ximan Bu Lei Wang Linlin Wu Xiaofeng Ma

Abstract The emerging application of ionogels in flexible devices require it enough durable under repeated mechanical deformation while maintaining their superior electrochemical properties. In this work, ultratough and recoverable ionogels, where ionic liquids are confined in chemically and interpolymer hydrogen‐bonding hybrid crosslinked network, were fabricated by in situ copolymerization of acrylic acid and 1‐vinylimidazole monomer within 1‐buty‐3‐methylimidazolium chloride ionic liquid. The reversible hydrogen bonds between imidazole and carboxylic acid groups of polymer chains in the network work as reversible “sacrificial bonds” to toughen ionogel, which makes the ionogels tough (tensile strength 1.62 MPa, toughness 8.7 MJ m −3 ), stretchable (elongation at break 1090%), and recoverable (91% recovery resting for 30 min, at 534 kPa stress and 500% strain). Moreover, the hydrogen‐bonded ionogels exhibit high ionic conductivity of 2.3 S m −1 at 80°C to 3.2 S m −1 at 150°C. Furthermore, the ionogel‐based flexible electrical double‐layer capacitor can be operated up to 1.5 V with a capacitance of 341.47 F g −1 at 0.5 A·g −1 and exhibits excellent capacitance retention after 1000 cycles as well as superior electrochemical performance over a wide range of temperature. This work provides new insights into the synthesis of tough and recoverable ionogels for high‐performance flexible supercapacitors.

Quasi-solid

10.1002/app.50259

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Citations (12)

[Effects of HO-1 on Lipopolysaccharide-induced Endoplasmic Reticulum Stress of Rat Hepatocytes].

PubMed (2015)

Yan-sha Wang Ying-lei Ji Tao Wang Linlin Wu Cheng-ping Fei

To investigate effects of antioxidant stress protein heme oxygenase-1 (HO-1) on lipopolysaccharide (LPS)-induced endoplasmic reticulum stress (ERS) of rat hepatocytes.The BRL cells (rat hepatocyte cell line) were cultured. The hepatocytes were treated with LPS, LPS+HO-1 siRNA, HO-1 siRNA and PBS solution, respectively. The cell viability was measured by trypan blue exclusion test. The apoptosis cells were detected by the fluorescent dye Hoechst 33258. Expressions of GRP78, CHOP, caspase-12 and HO-1 were detected by Western blotting.LPS caused an increase of HO-1 protein expression of rat hepatocytes in a dose-dependent and time-dependent manner, a up-regulation of GRP78, CHOP and caspase-12, a decrease in cell viability, and an increase in apoptosis rate of hepatocytes. Pretreatment of HO-1 siRNA inhibited the up-regulation of LPS-induced HO-1, however, aggravated ERS and cellular injury.HO-1 inhibites ERS-mediated cellular injury of rat hepatocytes induced by LPS.

Viability assay

Trypan blue

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Hydroxyethyl cellulose-based electrically conductive, mechanically resistant, strain-sensitive self-healing hydrogels

Cellulose (2022)

Imtiaz Hussain Xiaofeng Ma Linlin Wu Zhenyang Luo

Hydroxyethyl cellulose

Strain (injury)

Tension (geology)

10.1007/s10570-022-04622-6