Tatyana Suslova

Chelyabinsk Regional Clinical Oncology Center

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ОН

О. Н. Огуркова

Tomsk National Research Medical Center

Irina Shmunk

Chelyabinsk Regional Clinical Oncology Center

Olga Korobitsina

Regional Clinical Hospital No 4

Alexander Korobkin

Regional Clinical Hospital No 4

Marina Zakharova

City Clinical Hospital

Elena Koneva

Chelyabinsk Regional Clinical Oncology Center

АЛ

А. Л. Бурмистрова

Chelyabinsk State University

ВМ

В. М. Шипулин

Tomsk National Research Medical Center

O. A. Koshelskaya

Tomsk National Research Medical Center

A. V. Sitoshevsky

Cooperative Institutions

Tomsk National Research Medical Center

Russian Academy of Sciences

Institute of Cardiology

Academy of Medical Sciences

Regional Clinical Hospital No 4

Chelyabinsk Regional Clinical Oncology Center

Siberian State Medical University

City Clinical Hospital

Pirogov Russian National Research Medical University

University of Minnesota

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WTl expression for monitoring minimal residual disease in acute lymphoblastic leukemia patients

F1000Research (2010)

Irina Shmunk Elena Koneva Tatyana Suslova Marina Zakharova Olga Korobitsina

Minimal Residual Disease

Open peer review

10.7490/f1000research.729.1

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WT1 Expression for Monitoring Minimal Residual Disease In Acute Lymphoblastic Leukemia Patients

Blood (2010)

Irina Shmunk Elena Koneva Tatyana Suslova Marina Zakharova Olga Korobitsina

Minimal Residual Disease

10.1182/blood.v116.21.3234.3234

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Research of cGMP- and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of platelets aggregation activity in patients with heart failure and metabolic disturbances

Bulletin of Siberian Medicine (2012)

О. Н. Огуркова Tatyana Suslova A. V. Sitoshevsky O. A. Koshelskaya

Data of the study of cGMP- and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of the platelet aggregation activity in 25 patients with DM2 and heart failure are presented. 15 healthy volunteers were recruited as a control group. To estimate cAMP- and cGMP-dependent intracellular signaling systems in the realization of insulin antiaggregational effect we used 3-isobutyl-1-methyl-xanthine — inhibitor of the phosphodiesterase V and IV, forskolin — stimulator of adenylate cyclase, zaprinast — specific inhibitor of the phosphodiesterase V. Modifiers of the adenylate cyclase/cAMP system — IBMX and forskolin — had the most prominent effect on the reduction of the aggregation of the isolated platelets.

IBMX

Zaprinast

Phosphodiesterase inhibitor

Phosphodiesterase 3

PDE10A

10.20538/1682-0363-2012-6-76-81

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Citations (1)

Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients

Patologiya krovoobrashcheniya i kardiokhirurgiya (2015)

И. В. Пономаренко В. М. Шипулин О. Н. Огуркова Tatyana Suslova

Biocompatibility of heparin-based coating for extracorporeal circuits, the Bioline, was evaluated in cardiac surgery setting. Thirty six CABG pts, aged from 30 to 69 yrs, were randomly perfused with a circuit containing Bioline-coated Quadrox oxygenator (Bioline, n=18) or with a similar non-coated circuit (control, n=18). Leukocyte and platelet counts, levels of tumor necrosis factor, interleukin-6 and fibrinogen were assessed in arterial blood before, during and after cardiopulmonary bypass (CPB). Oxygenation and ventilation indices before and after surgery, post-operative chest tube drainage and transfusion volume as well as the duration of assisted ventilation were also measured. A platelet count and fibrinogen dropped less in the Bioline group significantly compared with that in control at the end of CPB (p<0,05) and after protamine administration (p<0,05). A leukocyte count and an interleukin-6 level increased more in controls after CPB (p<0,05) as well as oxygenation and ventilation indices, bleeding volume and intubation time (all p<0,05). Our results suggest surface heparinization with Bioline coating limited to the oxygenator ameliorates the inflammatory response, preserves fibrinogen and platelets, reduces blood loss postoperatively and improves lung function during CPB.

Oxygenator

Extracorporeal

10.21688/1681-3472-2013-2-51-56

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