Kai O. Lindros

Research Field

Rats chronically led ethanol developed liver injury only if they also received low doses of the alcohol dehydrogenase inhibitor, 4‐methylpyrazole, suggesting that the consistency of the influence of ethanol and its metabolism, rather than the level of acetaldehyde or the degree of the metabolic effects, contributes to the pathogenesis of alcoholic liver damage.

Ethanol metabolism

Liver damage

Pathogenesis

10.1111/j.1530-0277.1979.tb04773.x

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Citations (13)

Inefficacy of oxygenated drinking water in accelerating ethanol elimination in humans

Life Sciences (1979)

Maija Laakso Timo Huopaniemi Juhani Hyvärinen Kai O. Lindros Risto P. Roine

Oxygen tension

10.1016/0024-3205(79)90413-2

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Citations (4)

Hepatic gene expression and lipid parameters in complement C3−/− mice that do not develop ethanol-induced steatosis

Journal of Hepatology (2007)

Igor Bykov Matti Jauhiainen Vesa M. Olkkonen Sirkku T. Saarikoski Christian Ehnholm

Steatosis

Alcoholic fatty liver

Lipid droplet

10.1016/j.jhep.2006.11.020

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Citations (46)

Effect of chronic ethanol consumption on the expression of complement components and acute-phase proteins in liver

Clinical Immunology (2007)

Igor Bykov Sami Junnikkala Marcela Pekna Kai O. Lindros Seppo Meri

Complement factor B

Clusterin

10.1016/j.clim.2007.05.008

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Citations (42)

Zonal distribution of transcripts of four hepatic transcription factors in the mature rat liver.

Cell Biology and Toxicology (1997)

Kai O. Lindros Teija Oinonen Jouni Issakainen Péter Nagy S.S. Thorgeirsson

Northern blot

Transcription

10.1023/a:1007479223229

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Citations (45)

W11.273 Active phospholipid transfer protein (PLTP) is required for efficient secretion of apolipoprotein A-1 from liver cells

Atherosclerosis Supplements (2004)

Sarah Siggins Matti Jauhiainen Vesa M. Olkkonen Igor Bykov Kai O. Lindros

Phospholipid transfer protein

10.1016/s1567-5688(04)90272-9

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Citations (0)

Induction mechanisms of cytochrome P450 2E1 in liver: Interplay between ethanol treatment and starvation

Biochemical Pharmacology (1995)

Hu Yin Magnus Ingelman‐Sundberg Kai O. Lindros

Northern blot

10.1016/0006-2952(95)00128-m

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Citations (76)

Effect of Long-Term Ethanol Exposure on the Acinar Distribution of Hepatic Glutathione S-Transferase

Drug Metabolism and Disposition (2000)

Tamara Vanhaecke Kai O. Lindros Teija Oinonen Antoine Vercruysse Vera Rogiers

The ability of ethanol to affect the regional distribution of individual glutathione S-transferase (GST) isoenzymes in rat liver was investigated by analyzing the expression levels in cell lysates obtained from the periportal or perivenous liver region after in situ digitonin perfusion. In control rats, a significant perivenous dominance of GST proteins and activities measured by the substrates 1-chloro-2,4-dinitrobenzene (broad spectrum), 1, 2-dichloro-4-nitrobenzene (M1/M2-specific), and 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (A1/A2-specific) was found. In pair-fed rats exposed to ethanol (36% of total calories) for 2 weeks, all GST activities measured were significantly increased in both acinar zones. However, the relative increase was greater in the perivenous region. The induction of the A1/A2-specific activity was the most pronounced. HPLC analysis revealed for both regions that this increase was largely confined to the A2 subunit, with only minor effects observed on the A1 subunit. At the mRNA level, the constitutive perivenous dominance of both GST A1 and GST A2 expression became more pronounced after ethanol administration. The results demonstrate that long-term ethanol exposure induces individual GST isoenzymes differently and might have a profound effect on xenobiotic-induced regional liver damage.

Glutathione S-transferase

Xenobiotic

Metallothionein

10.1016/s0090-9556(24)13676-8

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Citations (11)

Alcoholic liver disease: pathobiological aspects

Journal of Hepatology (1995)

Kai O. Lindros

10.1016/s0168-8278(21)80001-x

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Citations (85)