Jamal Golbahar

North Devon District Hospital

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Gholam Reza Rezaian

Shiraz University of Medical Sciences

Mohammad A. Aminzadeh

Babol Noshirvani University of Technology

Zahra Fathi

Islamic Azad University Medical Branch of Tehran

Sara Al-Othman

Arabian Gulf University

Abdulla Darwish

Royal College of Surgeons in Ireland - Bahrain

Salah Kassab

Suez Canal University

Lyubomir Petrov

Siberian State Medical University

Sioned M. Griffiths

Betsi Cadwaladr University Health Board

Volker Klauß

München Klinik

Diab Eltayeb Diab

Arabian Gulf University

Cooperative Institutions

Arabian Gulf University

Shiraz University of Medical Sciences

University of Bahrain

Royal College of Surgeons in Ireland - Bahrain

Centre National de la Recherche Scientifique

Namazi Hospital

Shiraz University

Guy's and St Thomas' NHS Foundation Trust

Cardiff University

Ludwig-Maximilians-Universität München

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SELECTIVE SCREENING OF PHENYLKETONURIA,TYROSINEMIA AND MAPLE SYRUP URINE DISEASEIN SOUTHERN IRAN

Iranian journal of medical sciences (2015)

Jamal Golbahar Z. Honardar

Inborn errors of amino-acids metabolism and other inherited Mendeliandisorders are common in the MiddleEast. The number of diagnosed inborn errors of amino acid metabolism is growing constantly on account of and availability and improved of analytical techniques. The aim of this work was to determine a rough estimate of the incidence rates of phenylketonuria (PKU), tyrosinemia, and maple syrup urine disease (MSUD) in Fars Province, South of Iran. Using a high performance liquid chromatography, 1044 patients with signs and symptoms suggestive of PKU, tyrosinemia and MSUD were investigated between 1996 and 2001, for the presence of the disorders. Of 1044 patients, 43 cases (4.1%) with PKU, 15 (1.4%) with tyrosinemia and 6 (0.6%) with MSUD were diagnosed. The incidence rates of PKU, tyrosinemia and MSUD were found to be 27.2 , 9.4, and 4.7 per 100,000 births, respectively. The incidence rates of PKU, tyrosinemia and MSUD in our region is higher than the rates reported from Europe presumably because of the relatively higher rates of consanguinity.

Tyrosinemia

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Citations (4)

The angiotensin type 1 receptor antagonist valsartan attenuates pathological ventricular hypertrophy induced by hyperhomocysteinemia in rats

Journal of the Renin-Angiotensin-Aldosterone System (2006)

Salah Kassab Taysir Garadah Marwan Abu‐Hijleh Jamal Golbahar Solomon S. Senok

Clinical and experimental studies have reported the role of homocysteine in ventricular hypertrophy. Activation of the renin-angiotensin system mediated by angiotensin II type 1 (AT1) receptor has also been suggested to contribute to the pathogenesis of ventricular hypertrophy. There are also reports suggesting the affect of angiotensin II (Ang II) on cardiac hypertrophy is mediated by hyperhomocysteinemia. However, there is limited information on the mechanisms of the possible relationship between homocysteine and Ang II in ventricular hypertrophy. In this study we tested the hypothesis that hyperhomocysteinemia induced ventricular hypertrophy and remodelling may be mediated through activation of Ang II AT1-receptors in rats.This study was conducted on control non-treated rats (n=13), methionine-treated rats (1.5 mg/kg/day, n=18) and methionine plus oral AT1 antagonist (valsartan, 30 mg/kg/day, n=13) treated rats for 56 days. Systolic blood pressure (SBP) was determined in rats at baseline, 28 and 56 days. Echocardiography was also performed in all rats after eight weeks, and blood samples were obtained for determination of plasma tHcy. Rats were then sacrificed for histopathological and biochemical assessment of cardiac structure.The SBP in the methionine-treated rats was significantly higher compared with controls and significantly lower compared with the methionine-valsartan group at 28 and 56 days (p<0.001). In addition, left ventricular wall thickness (LVWT) in the methionine-valsartan group (4.36+0.11 mm) was significantly lower compared with the methionine group (5.0+0.23 mm, p=0.03). Furthermore, cardiac collagen to total protein ratio was significantly lower in the methionine-valsartan group (2.19+0.11%) compared with the methionine group (2.64+0.08%, p=0.026). Fractional shortening (FS) was not significantly different between groups.Results from this study suggest that hyperhomocysteinemia-induced hypertension and ventricular hypertrophy in rats are mediated, at least partly; by Ang II activation of AT1-receptors.

Hyperhomocysteinemia

Ventricular hypertrophy

10.3317/jraas.2006.039

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Selective newborn screening of inborn errors of amino acids, organic acids and fatty acids metabolism in the Kingdom of Bahrain

Molecular Genetics and Metabolism (2013)

Jamal Golbahar Emtithal Aljishi D.D. Altayab E. Carreon Moiz Bakhiet

10.1016/j.ymgme.2013.07.006

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Citations (41)

Conference Calendar

Journal of Vascular Research (2005)

Jin H. Song Salima J. Alladina Alexander S. Easton Sandra T. Davidge Chunhai Hao

10.1159/000087341

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Association of red blood cell 5-methyltetrahydrfoate folate with bone mineral density in postmenopausal Iranian women

Osteoporosis International (2005)

Jamal Golbahar M Aminzadeh Sahand Hamidi Gholamhossein Ranjbar Omrani

10.1007/s00198-005-1961-x

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Citations (32)

Distribution of plasma total homocysteine concentrations in the healthy Iranians

Clinical Biochemistry (2003)

Jamal Golbahar Gholam Reza Rezaian Hadi Bararpour

Plasma homocysteine

10.1016/j.clinbiochem.2003.10.005

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Citations (20)

Efficacy of fine‐needle aspiration biopsy in diagnosis of breast cancer: A retrospective study of 303 cases in Bahrain

Diagnostic Cytopathology (2009)

Khalid Al‐Sindi Nahid Kamal Jamal Golbahar

Breast cancer is a leading cause of death in many countries worldwide and breast lesions remain a common diagnostic dilemma. Fine-needle aspiration biopsy (FNAB) has been suggested as the most important, first line, minimally invasive measure in the management of patients with breast lesions. The aim of this study is to evaluate the efficacy of FNAB in patients with breast lesions by comparing the diagnostic accuracy of cytology results with that of the definitive histological examination outcome and also to investigate the added value of a single aspirator experience to the overall diagnostic precision and compared with the internationally published results. A retrospective study of 303 breast FNAB samples were carried out by a single experienced cytopathologist with complete comparison records.The prevalence of positive cytologic diagnosis for the breast cancer was determined to be 20.4%. The overall diagnostic accuracy of FNAB was 97.9%, with a specificity and sensitivity of 98.3 and 96.5%, respectively. The overall positive and negative predictive values were determined to be 93.2 and 99.2%, respectively. In addition, the sensitivity was comparable in cases that have been attempted by palpation-guided sampling compared with those aspirations that were carried out under US guidance.Results from this study confirm that FNAB biopsies performed and reported by a dedicated, single, skilled cytopathologist are highly effective in diagnosis of breast lesions and reliable in differentiating benign and malignant breast lesions with an overall high efficacy in a specialized laboratory-based FNAB clinic.

Palpation

Cytopathology

Gold standard (test)

Breast lumps

10.1002/dc.21074

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Citations (5)

Association of vitamin D deficiency and hyperparathyroidism with anemia: a cross-sectional study

Journal of Blood Medicine (2013)

Jamal Golbahar Altayab Elizareth Carreon Abdulla Darwish

Vitamin D deficiency and anemia are common in the Middle East, and vitamin D deficiency and hyperparathyroidism have been reported to be associated with an increased prevalence of anemia. In this study, the hypothesis that vitamin D deficiency and hyperparathyroidism may be associated with anemia in a Bahraini population was tested. Association of hyperparathyroidism and vitamin D levels (deficiency and insufficiency) with anemia was investigated in 421 Bahrainis (213 males and 208 females). In females, the prevalence of anemia was significantly associated with vitamin D deficiency independent of parathyroid hormone levels (odds ratio: 2.9; 95% confidence interval: 2.3-10.5; P = 0.001). In females, the prevalence of anemia appeared to be significantly associated with hyperparathyroidism (odds ratio: 2.1; 95% confidence interval: 1.2-3.7; P = 0.01); however, this significant association disappeared when adjusted for vitamin D deficiency (odds ratio: 1.6; 95% confidence interval: 0.75-6.5; P = 0.154). Results from this study suggest that vitamin D deficiency is independently associated with anemia in females but not males. Further studies to determine whether vitamin D supplementation could be used to treat anemia are warranted.

Cross-sectional study

10.2147/jbm.s47171

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Citations (11)

Association between Low Red Blood Cell 5-Methyltetrahydrofolate and Hyperhomocysteinaemia with Hypertension

High Blood Pressure & Cardiovascular Prevention (2012)

Jamal Golbahar Ehsan Mostafavi

Quartile

10.1007/bf03297635

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Citations (6)

Neonatal Screening for Congenital Hypothyroidism: A Retrospective Hospital Based Study from Bahrain

Journal of Pediatric Endocrinology and Metabolism (2010)

Jamal Golbahar Haya Alkhayyat Babiker Hassan Wahid Agab Essa Hassan

Article Neonatal Screening for Congenital Hypothyroidism: A Retrospective Hospital Based Study from Bahrain was published on February 1, 2010 in the journal Journal of Pediatric Endocrinology and Metabolism (volume 23, issue 1-2).

Congenital hypothyroidism

Thyroid-stimulating hormone

Cord blood

10.1515/jpem.2010.23.1-2.39

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Citations (10)