The present study concerns behavioral, biochemical and hematological effects of new synthesized adrenergic related compound 1-(3, 4-dihydroxyphenyl)-2-(4-methylpiperidin-1-yl) ethan-1-one, which have similar structural activity to adrenergic receptor agonist. With intraperitoneal injection in rats, stimulatory activity in home cage, anxiolytic effect in light and dark and locomotors activity in open field were significantly increased. Biochemical effects of glucose and cholesterol were checked by kit (CHOD-PAP) method were significantly decreased. Liver enzymes including, Alkaline Phosphatase (ALP) and SGOT were markedly decreased but, Alanine aminotransferase (ALT) level was markedly increased. In hematological study, after administration of compound hemoglobin (Hb) level was significantly increased in test group of rats. Results indicate that new adrenergic related antidepressant compound not only enhanced the stimulation, locomotion and released depression and anxiety but also, this antidepressant compound show more effectiveness in depression to prevent diabetes and heart diseases.
Aim:To study the effect of Panadol extra on blood and behavior of rats.Methods: Locally bred male albino Wister rats weighing about 145 to 155 g on arrival purchased from animal house, research institute of Agha Khan University Karachi Pakistan were used throughout the experiments.Total of 24 rats were grouped into two: 12 rats called control and 12 test group.Normal saline was given to control while, 500 mg/tablet (extra Panadol) into 30 mg/kg body weight was dissolved in water and was given to rats.Behavioral study was observed.After 3 weeks of treatment rats were decapitated.Automated Hematology Analyzer SYSMEX XP 100 and Biochemical analyzer the Roche/Hitachi 902 was used for liver enzymes and hematological analysis. Results:Panadol extra has no effect on locomotor activity and the effect of stimulatory activity of rats increases.Depression and anxiety of rats decreases and at the same time it is useful to enhance memory.Hematological parameters and liver enzymes were also non-significantly decreased in test group of rats as compare to control group.Panadol extra is considered a good choice of drug and its side effects are very rare if it is used properly but by frequent and prolonged or excessive use of Panadol extra rats become unable to Fight against diseases and it also highly significantly decreases the PLT count by which their blood clotting mechanism is highly disturbed.
Aim: To determine the effect of doxorubicin on locomotion, stimulation, depression and catechol amines (dopamine and 5HT).
Methods: Experimental drug doxorubicin was used as an anticancer drug. It was dissolved in saline and injected intraperitoneally to test group of rats. It was observed very little has been reported on the behavioural effects. Three behavioural studies were observed, which include open field activity specific for locomotion, light and dark activity specific for depression, and home cage activity specific for stimulation after one week, two weeks, three weeks and four weeks of doxorubicin treatments. To determine the concentration of dopamine and 5HT in brain, rats were decapitated gradually and analysed by HPLC-EC detector, results were observed very carefully.
Results: Locomotors activity and stimulatory activity were decreased when the concentration of doxorubicin increased gradually and depression was markedly appeared. The mean value of dopamine and 5HT were decreased markedly in TG group of rats as compared to CG group of rats.
Conclusion: Doxorubicin has negative effect on locomotion and stimulation, but produces the positive effect on depression. These activities were depending upon the concentrations of catecholamine’s (dopamine and 5HT). It was also observed that dopamine and 5HT were also significantly decreased.
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