Huan Qi

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Anulamycins A–F, Cinnamoyl-Containing Peptides from a Lake Sediment Derived Streptomyces

Journal of Natural Products (2023)

Han Wang Huan Qi Hui Zhang Shaoyong Zhang Chenghong Zhang

Bioinformatics analysis of a whole genome sequence coupled with HPLC-DAD analysis revealed that Streptomyces sp. Hu103 has the capacity to produce skyllamycin analogues. A subsequent chemical investigation of this strain yielded four new cinnamoyl-containing cyclopeptides, anulamycins A–D (1–4), two new cinnamoyl-containing linear peptides, anulamycins E and F (5 and 6), and two known cyclopeptides, skyllamycins A (7) and B (8). Their structures including absolute configurations were elucidated by detailed analysis of NMR and HRESIMS/MS spectroscopic data and the advanced Marfey’s method. Compounds 1–4 exhibited antibacterial activity comparable to those of skyllamycins A and B.

10.1021/acs.jnatprod.2c00967

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A new naphthalenepropanoic acid analog from the marine-derived actinomycetes Micromonospora sp. HS-HM-036

Journal of Asian Natural Products Research (2016)

Meiyue Gao Huan Qi Jiansong Li Hui Zhang Ji Zhang

A new naphthalenepropanoic acid analog (1) was isolated from the broth of the actinomycetes Micromonospora sp. HS-HM-036. The structure of compound 1 was determined based on MS and extensive NMR analysis. A preliminary investigation of the biological activity of compound 1 was also described.

Micromonospora

10.1080/10286020.2016.1264393

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Citations (4)

Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06

The Journal of Antibiotics (2024)

Hui Zhang Zhenyu Wang Huan Qi Shao-yong Zhang Jun Huang

Streptomyces avermitilis

10.1038/s41429-024-00754-y

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Two new spliceostatin analogs from the strain Pseudomonas sp. HS-NF-1408

The Journal of Antibiotics (2018)

Yue Zhao Junwei Zhao Chang Lu Hui Zhang Huan Qi

Strain (injury)

10.1038/s41429-018-0052-0

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Two new lankacidin-related metabolites from Streptomyces sp. HS-NF-1178

The Journal of Antibiotics (2018)

Chang Lu Jinmeng Li Huan Qi Hui Zhang Ji Zhang

Streptomycetaceae

10.1038/s41429-017-0004-0

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Two novel milbemycin derivatives from the genetically engineered strain Streptomyces avermitilis AVE-H39

The Journal of Antibiotics (2020)

Huan Qi Ji Zhang Zhikui Hao Shaoyong Zhang Jiansong Li

Streptomyces avermitilis

Strain (injury)

Genetically engineered

Avermectin

10.1038/s41429-020-0317-2

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Citations (5)

Morindolestatin, Naturally Occurring Dehydromorpholinocarbazole Alkaloid from Soil-Derived Bacterium of the Genus Streptomyces

Organic Letters (2020)

Shaoyong Zhang Zha‐Jun Zhan Hui Zhang Huan Qi Liqin Zhang

Novel antilipid peroxidative carbazole alkaloids, antiostatin A5 (1), antiostatin A6 (2), and (±)-morindolestatin (3), were isolated from a new soil-derived Streptomyces sp. Compound 2 possesses an unusual cyclohexene side chain. Compound 3 was a pair of enantiomers featuring an unprecedented [1,4]oxazino[2,3-c]carbazole ring system. The absolute configuration of 3 was determined by online HPLC-ECD and ECD calculation. A racemization mechanism and putative biosynthetic pathway are discussed.

Racemization

Carbazole

Absolute Configuration

10.1021/acs.orglett.9b04609

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Citations (14)

Molluscicidal activity and biochemical impacts of borrelidins against an aquatic invasive snail Pomacea canaliculata for crop protection

Pesticide Biochemistry and Physiology (2024)

Jingyan Wang Zhihang Shi Zihuan Wu Han Wang Huan Qi

Pomacea canaliculata

Molluscicide

Niclosamide

10.1016/j.pestbp.2024.106105

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Two new threonine-containing metabolites from fungus Curvularia inaequalis strain HS-FG-257

Natural Product Research (2020)

Shaoyong Zhang Jiansong Li Hui Zhang Huan Qi Ruijun Wang

Two new threonine-containing metabolites, N-[4-hydroxy-3-prenyl-benzoyl]-L-threonine (1) and N-[2,2-dimethyl-2H-chromene-6-carbonyl]-L-threonine (2), were isolated from the fermentation broth of the soil fungus Curvularia inaequalis strain HS-FG-257. Their structures were elucidated through the interpretation of HR-ESIMS and extensive NMR spectroscopic data. Both compounds exhibited no cytotoxic activity against the test cell lines A549 and HCT-116.

Strain (injury)

10.1080/14786419.2020.1784168

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Citations (1)

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