T Bettecken

Max Planck Institute of Psychiatry

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A Erhardt

Max Planck Institute of Psychiatry

M Uhr

Max Planck Institute of Psychiatry

Jan M. Deussing

Max Planck Institute of Psychiatry

Bertram Müller‐Myhsok

Max Planck Institute of Psychiatry

M. A. Kohli

Dr. John T. Macdonald Foundation

Martin E. Keck

Max Planck Institute of Psychiatry

Sher Schreiber

Kiel University

Christa Hohoff

University of Münster

Stefan Kloiber

Centre for Addiction and Mental Health

Mariya Gonik

Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology

Cooperative Institutions

Max Planck Institute of Psychiatry

Max Planck Society

Ludwig-Maximilians-Universität München

Heidelberg University

Central Institute of Mental Health

University Hospital Heidelberg

University of Münster

Klinik und Poliklinik für Psychiatrie und Psychotherapie

University of Würzburg

Universitätsklinikum Würzburg

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TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies

Molecular Psychiatry (2010)

A Erhardt Ludwig Czibere Darina Roeske Susanne Lucae Paul G. Unschuld

Genome-wide Association Study

SNP

Candidate gene

Genetic Association

10.1038/mp.2010.41

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Citations (151)

Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients

Pharmacopsychiatry (2007)

A Heck R Lieb A Ellgas H Pfister S Lucae

A number of studies provide evidence that the angiotensin-converting enzyme (ACE) gene is involved in the vulnerability for stress-related disorders including cardiovascular diseases and mental disorders. These associations are assumed to be mediated by the effects of ACE on angiotensin II, which in turn affects the vascular tone and modulates the activation of the hypothalamic-pituitary-adrenocortical (HPA) axis. Dispositional coping styles are important moderators of the stress reaction, and are altered in cardiovascular diseases as well as in mental disorders. We examine the hypothesis that polymorphisms of the ACE gene region are also associated with dispositional coping styles. 543 mentally healthy subjects and 195 patients suffering from depression were examined. Coping styles were assessed with a self-report questionnaire (German Stress Coping Questionnaire SVF78) measuring the individual coping style pattern in response to stressful situations. We genotyped 13 single nucleotide polymorphisms (SNPs) in the ACE gene region and investigated their associations with coping styles. In healthy subjects, the highest association was observed between the intronic SNP rs8066276, and the coping factor Distraction. A further SNP rs4305, not in linkage disequilibrium with rs8066276, showed an association with Devaluation/Defense. Both SNPs were also associated with positive coping in the patients; rs8066276 was associated with Devaluation/Defense, and rs4305 with Control.

SNP

Linkage Disequilibrium

10.1055/s-2007-991694

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