Hae Ju Kang

Rural Development Administration

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i-10 index

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In Guk Hwang

Rural Development Administration

Ji Yeong Kim

Rural Development Administration

Byung Soon Hwang

Jeonbuk National University

Su Hyun Kwon

Rural Development Administration

Mi Jang

National IT industry Promotion Agency

Gi Chang Kim

Rural Development Administration

Kyung Hoon Min

Korea University

Gi-Chang Kim

Rural Development Administration

Seong‐Hoon Kim

Uijeongbu St. Mary's Hospital

Kingsley Ochar

Rural Development Administration

Cooperative Institutions

Rural Development Administration

Instituto de Ciencias Agrarias

Seoul National University

Chung-Ang University

National Institute of Agricultural Science and Technology

Korea University

National Academy of Agricultural Science

Sungkyunkwan University

Hanmi Pharmaceutical (South Korea)

Chonnam National University

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Variations of Major Glucosinolates in Diverse Chinese Cabbage (Brassica rapa ssp. pekinensis) Germplasm as Analyzed by UPLC-ESI-MS/MS

International Journal of Molecular Sciences (2024)

Seong‐Hoon Kim Kingsley Ochar Kanivalan Iwar Yoon-Jung Lee Hae Ju Kang

In this study, the variability of major glucosinolates in the leaf lamina of 134 Chinese cabbage accessions was investigated using Acquity ultra-performance liquid chromatography (UPLC-ESI-MS/MS). A total of twenty glucosinolates were profiled, of which glucobrassicanapin and gluconapin were identified as the predominant glucosinolates within the germplasm. These two glucosinolates had mean concentration levels above 1000.00 μmol/kg DW. Based on the principal component analysis, accessions IT186728, IT120044, IT221789, IT100417, IT278620, IT221754, and IT344740 were separated from the rest in the score plot. These accessions exhibited a higher content of total glucosinolates. Based on the VIP values, 13 compounds were identified as the most influential and responsible for variation in the germplasm. Sinigrin (r = 0.73), gluconapin (r = 0.78), glucobrassicanapin (r = 0.70), epiprogoitrin (r = 0.73), progoitrin (r = 0.74), and gluconasturtiin (r = 0.67) all exhibited a strong positive correlation with total glucosinolate at p < 0.001. This indicates that each of these compounds had a significant influence on the overall glucosinolate content of the various accessions. This study contributes valuable insights into the metabolic diversity of glucosinolates in Chinese cabbage, providing potential for breeding varieties tailored to consumer preferences and nutritional demands.

Brassica rapa

Germ plasm

10.3390/ijms25094829

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Anthocyanin Content in Mulberry according to Cultivars and Growing Region

Journal of the Korean Society of Food Science and Nutrition (2022)

Mi Jang Ji Yeong Kim Gi-Chang Kim Hae Ju Kang In Guk Hwang

The purpose of this study was to validate an analytical method for assessing the anthocyanin content in mulberry.The ultra-performance liquid chromatography (UPLC) method was validated in accordance with the International Conference on Harmonization guidelines for analytical procedures with respect to specificity, precision, accuracy, and linearity.The correlation coefficient values of cyanidin-3-glucoside (C3G) and cyanidin-3-rutinoside (C3R) were 1,000 and 0.999 respectively, and 0.20 and 0.60 μg/mL respectively for C3R.The analysis of the anthocyanin content of mulberry cultivars showed that, Simkang had the highest levels of C3G and C3R, followed by the upper Gwasang2.Analysis was carried out using the Gwasang2 variety because of its large fruit size and high Brix content.An analysis of the two regional (Buan, Gochang) varieties of Gwasang2 showed that, the anthocyanin content was different for each cultivation area.However, there was no significant difference in the overall content.

Content (measure theory)

10.3746/jkfn.2022.51.3.289

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Synthesis of Quinazoline Analogues with Differential Activity for HER2-overexpressing Breast Cancer Cells

Bulletin of the Korean Chemical Society (2015)

Sunyoung Jang Seul Lee Mi‐Ra Kim Young Jin Ham Mi Young

Quinazoline

10.1002/bkcs.10358

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Anti-Aging Effects of Antirrhinum majus L. Extract on UVB-Induced Human Skin Fibroblasts

Journal of the Korean Society of Food Science and Nutrition (2020)

Mi Jang In Guk Hwang Hae Ju Kang Byung‐Soon Hwang Gi-Chang Kim

UVB 노출에 의한 피부의 탄력감소 및 주름은 콜라겐 분해 효소인 MMPs와 type-1 콜라겐 생성과 매우 관련이 깊다. 본 실험에서는 금어초 추출물이 UVB 노출에 의해 유도된 콜라겐 분해효소인 MMP-1 생성과 콜라겐 합성에 어떠한 영향을 주는지 조사하였다. 그 결과 금어초 추출물은 세포내외로 분비되는 MMP-1의 생성을 유의적으로 억제하고 콜라겐의 합성을 촉진시키는 효과를 보였다. 그리고 세포내에서 MMP-1 발현과 관련이 깊은 mRNA 전사는 억제하고 type-1 콜라겐과 연계된 mRNA 전사는 촉진한다는 결과를 확인했다. 이는 금어초 추출물의 처리가 UVB에 노출된 피부의 탄력감소 및 주름 개선에 있어 긍정적인 효과가 있음을 시사하는 바이다. 이러한 효과는 금어초가 함유하고 있는 다양한 플라보노이드 성분에 기인하는 것으로 추정되며 식물 추출물에서 더 나아가 단일 혹은 복합성분에 대한 추가적인 연구가 필요할 것으로 생각된다. 또한, 효과를 보인 성분에 대해서 ROS의 라디칼 소거 및 MMP-1 생성과의 복합적인 상관관계에 대한 명확한 기작 연구가 수행된다면 금어초가 피부 건강과 관련된 유망한 기능성 소재가 될 것으로 생각된다.

Antirrhinum majus

Skin Aging

Human skin

10.3746/jkfn.2020.49.8.788

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Synthesis and Biological Evaluation of Biarylamide Derivatives as Inhibitors of Phagocytosis in Macrophages

Bulletin of the Korean Chemical Society (2016)

Hae Ju Kang Jiho Song Kee Hyeob Hyun Seung Hwarn Jeong Jung Wuk Lee

10.1002/bkcs.11036

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Evaluation of the Antioxidant Activities in Cabbage (Brassica oleracea var. capitata) Accessions

Journal of the Korean Society of Food Science and Nutrition (2023)

Jisu Ha So Eun Park In Guk Hwang Kyeong Won Bang Seong‐Hoon Kim

Jisu Ha, So Eun Park, In Guk Hwang, Kyeong won Bang, Seong-Hoon Kim, Jun Gu Lee, Chang-sun Choi, and Hae Ju Kang. Journal of the Korean Society of Food Science and Nutrition 2023;52:679-90. https://doi.org/10.3746/jkfn.2023.52.7.679

Capitata

10.3746/jkfn.2023.52.7.679

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Citations (1)

배추 유전자원의 항산화 효과

Byung Soon Hwang Ji-Yong Kim Su Hyun Kwon Gi-Chang Kim Hae Ju Kang

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Chemical Composition, Antioxidant and Anti-Inflammatory Potential in Whole, Flesh, and Peels of Codonopsis lanceolata Roots

Journal of the Korean Society of Food Science and Nutrition (2023)

Ji Yeong Kim Hee Sun Yang Hae Ju Kang Jeong‐Sook Choe In Guk Hwang

This study compares the chemical composition, antioxidant effect, and anti-inflammatory potential of different parts (whole, flesh, and peels) of Codonopsis lanceolata roots (CLR).Component analysis performed using liquid chromatography (LC) revealed that the contents of vitamin B2, B3, tangshenoside I, lobetyolin, lancemaside A, and total polyphenol were highest in the CLR peels.Moreover, the peels also showed the highest antioxidant activity.All components of the CLR inhibited oxidative stress and enhanced mitochondrial biogenesis in LPS-treated RAW 264.7 cells, as quantified using fluorescent probes.Results of the Griess assay and enzyme-linked immunosorb ent assay, revealed that exposure to CLR suppressed the production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines.CLR treatment also reduced the expression levels of cyclooxygenase-2 and inducible nitric oxide synthase protein through the regulation of nuclear factor-κB and mitogen-activated protein kinase signaling pathways, respectively, as determined by western blot.The findings of this study suggested that the CLR peels have a higher concentration of bioactive compounds than the amounts obtained in the flesh tissues of CLR.Thus, we propose that consuming CLR with the peel is more beneficial to the human body, than eating peeled.

Flesh

Codonopsis

10.3746/jkfn.2023.52.1.26

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피부 섬유아세포에서 금어초 추출물의 UVB에 의한 광노화 억제 효과

Mi Jang In Guk Hwang Hae Ju Kang Byung Soon Hwang Gi-Chang Kim

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Validation of Analytical Method and Procyanidin B2, C1 Content in Korean Apple Cultivars

Journal of the Korean Society of Food Science and Nutrition (2021)

Ji Yeong Kim Ha Na Jang Gi Chang Kim Hae Ju Kang In Guk Hwang

Procyanidin is a major functional component of apples.This study sought to verify an analytical method to evaluate the procyanidin B2 and C1 content by varieties, parts, and farms of apples.The linearity of the method developed using ultra performance liquid chromatography (UPLC) was excellent, and the correlation coefficients (R 2 ) of procyanidin B2 and C1 were 0.9996 and 0.9996, respectively.The limits of detection of procyanidin B2 and C1 were 0.70 and 0.77 µg/mL and limits of quantification were 2.14 and 2.32 µg/mL, respectively.The relative standard deviation (RSD) of the intra-day and inter-day were calculated and had excellent precision and was found to be within 5%.The RSD of the recovery rate of procyanidin B2 and C1 were 0.68∼3.33%and 1.63∼2.78%,respectively.Through this, the analytical method for estimating procyanidin was confirmed.Analysis of procyanidin in the different apple varieties (Summerking, Gamhong, Hongro, Arisu, Busa), showed that Gamhong had significantly (P<0.05)higher procyanidin B2 and C1 content compared to other varieties, and the peel had the highest procyanidin B2 and C1 content.When the procyanidin content of Gamhong collected from ten farms was analyzed, the average content of procyanidin B2 in the peel was 9.79 mg/100 g FW and that of procyanidin C1 was 11.58 mg/100 g FW.Heretofore, information on the procyanidin content in apples grown in Korea was insufficient.Therefore, it is considered that the results of this study can be considered necessary to improve the usability of apples.

10.3746/jkfn.2021.50.11.1258

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