Abstract Background The pathogenesis of migraine chronification remains unclear. Functional and structural magnetic resonance imaging studies have shown impaired functional and structural alterations in the brains of patients with chronic migraine. The cerebellum and periaqueductal gray (PAG) play pivotal roles in the neural circuits of pain conduction and analgesia in migraine. However, few neurotransmitter metabolism studies of these migraine-associated regions have been performed. To explore the pathogenesis of migraine chronification, we measured gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx) levels in the dentate nucleus (DN) and PAG of patients with episodic and chronic migraine and healthy subjects. Methods Using the MEGA-PRESS sequence and a 3-Tesla magnetic resonance scanner (Signa Premier; GE Healthcare, Chicago, IL, USA), we obtained DN and PAG metabolite concentrations from patients with episodic migraine ( n = 25), those with chronic migraine ( n = 24), and age-matched and sex-matched healthy subjects ( n = 16). Patients with chronic migraine were further divided into those with ( n = 12) and without ( n = 12) medication overuse headache. All scans were performed at the Beijing Tiantan Hospital, Capital Medical University. Results We found that patients with chronic migraine had significantly lower levels of GABA/water (p = 0.011) and GABA/creatine (Cr) (p = 0.026) in the DN and higher levels of Glx/water (p = 0.049) in the PAG than healthy controls. In all patients with migraine, higher GABA levels in the PAG were significantly associated with poorer sleep quality (GABA/water: r = 0.515, p = 0.017, n = 21; GABA/Cr: r = 0.522, p = 0.015, n = 21). Additionally, a lower Glx/Cr ratio in the DN may be associated with more severe migraine disability ( r = -0.425, p = 0.055, n = 20), and lower GABA/water ( r = -0.424, p = 0.062, n = 20) and Glx/Water ( r = -0.452, p = 0.045, n = 20) may be associated with poorer sleep quality. Conclusions Neurochemical levels in the DN and PAG may provide evidence of the pathological mechanisms of migraine chronification. Correlations between migraine characteristics and neurochemical levels revealed the pathological mechanisms of the relevant characteristics.

Periaqueductal gray

Dentate nucleus

Gamma-Aminobutyric Acid

Proton magnetic resonance

10.1186/s10194-022-01452-6

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Citations (17)

Clinical effectiveness of reduction and fusion versus in situ fusion in the management of degenerative lumbar spondylolisthesis: a systematic review and meta-analysis

European Spine Journal (2023)

Dongfan Wang Wei Wang Di Han Sathish Muthu Juan P. Cabrera

10.1007/s00586-023-08041-4

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Citations (2)

Treatment of osteonecrosis of the femoral head with thorough debridement, bone grafting and bone-marrow mononuclear cells implantation

European Journal of Orthopaedic Surgery & Traumatology (2013)

Tao Wang Wei Wang Zong Sheng Yin

Iliac crest

Cancellous bone

Bone grafting

Avascular Necrosis

Debridement (dental)

10.1007/s00590-012-1161-2

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Citations (37)

Convergence mechanism of mindfulness intervention in treating attention deficit hyperactivity disorder: Clues from current evidence

World Journal of Clinical Cases (2022)

Xinpeng Xu Wei Wang Song Wan Chunfeng Xiao

This paper reviews the underlying evidence for various aspects of the convergence mechanism of mindfulness intervention in attention deficit hyperactivity disorder (ADHD). There may be compatibility among various ADHD remission models and the therapeutic mechanism of mindfulness intervention in ADHD may be mainly via the convergence mechanism. However, neuroimaging-based analysis of the mechanisms of mindfulness intervention in treating ADHD is lacking. Differences in the efficacy of various subtypes of mindfulness intervention, and corresponding specific imaging changes need further investigation. Future research may focus on the neuroimaging features of specific mindfulness intervention subtypes.

10.12998/wjcc.v10.i26.9219

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Citations (1)

Improved temporal clustering analysis method applied to whole-brain data in acupuncture fMRI study

Magnetic Resonance Imaging (2007)

Na Lü Baoci Shan Jianyang Xu Wei Wang Kuncheng Li

10.1016/j.mri.2007.02.010

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Citations (3)

Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space

The Journal of Headache and Pain (2023)

Xue Zhang Wei Wang Xiaoyan Bai Xueyan Zhang Ziyu Yuan

Abstract Background Preliminary evidence suggests that several headache disorders may be associated with glymphatic dysfunction. However, no studies have been conducted to examine the glymphatic activity in migraine chronification. Purposes To investigate the glymphatic activity of migraine chronification in patients with episodic migraine (EM) and chronic migraine (CM) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method. Methods In this cross-sectional study, patients with EM, CM, and healthy controls (HCs) were included. All participants underwent a standard brain magnetic resonance imaging (MRI) examination. Bilateral DTI-ALPS indexes were calculated for all participants and compared among EM, CM, and HC groups. Correlations between the DTI-ALPS index and clinical characteristics were analyzed. Results A total of 32 patients with EM, 24 patients with CM, and 41 age- and sex-matched HCs were included in the analysis. Significant differences were found in the right DTI-ALPS index among the three groups ( p = 0.011), with CM showing significantly higher values than EM ( p = 0.033) and HCs ( p = 0.015). The right DTI-ALPS index of CM group was significantly higher than the left DTI-ALPS index ( p = 0.005). And the headache intensity was correlated to DTI-ALPS index both in the left hemisphere ( r = 0.371, p = 0.011) and in the right hemisphere ( r = 0.307, p = 0.038), but there were no correlations after Bonferroni correction. Conclusions Glymphatic system activity is shown to be increased instead of impaired during migraine chronification. The mechanism behind this observation suggests that increased glymphatic activity is more likely to be a concomitant phenomenon of altered vascular reactivity associated with migraine pathophysiology rather than a risk factor of migraine chronification.

Glymphatic System

10.1186/s10194-023-01673-3

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High expression of type I inositol 1,4,5-trisphosphate receptor in the kidney of rats with hepatorenal syndrome

World Journal of Gastroenterology (2018)

Jingbo Wang Ye Gu Mingxiang Zhang Shun Yang Yan Wang

To detect the expression of type I inositol 1,4,5-trisphosphate receptor (IP

Galactosamine

Acute tubular necrosis

10.3748/wjg.v24.i29.3273

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Disrupted properties of functional brain networks in major depressive disorder during emotional face recognition: an EEG study via graph theory analysis

Frontiers in Human Neuroscience (2024)

Chaolin Teng Lin Cong Wei Wang Shan Cheng Min Wu

Previous neuroimaging studies have revealed abnormal brain networks in patients with major depressive disorder (MDD) in emotional processing. While any cognitive task consists of a series of stages, little is yet known about the topology of functional brain networks in MDD for these stages during emotional face recognition. To address this problem, electroencephalography (EEG)-based functional brain networks of MDD patients at different stages of facial information processing were investigated in this study. First, EEG signals were collected from 16 patients with MDD and 18 age-, gender-, and education-matched normal subjects when performing an emotional face recognition task. Second, the global field power (GFP) method was employed to divide group-averaged event-related potentials into different stages. Third, using the phase transfer entropy (PTE) approach, the brain networks of MDD patients and normal individuals were constructed for each stage in negative and positive face processing, respectively. Finally, we compared the topological properties of brain networks of each stage between the two groups using graph theory approaches. The results showed that the analyzed three stages of emotional face processing corresponded to specific neurophysiological phases, namely, visual perception, face recognition, and emotional decision-making. It was also demonstrated that depressed patients showed abnormally decreased characteristic path length at the visual perception stage of negative face recognition and normalized characteristic path length in the stage of emotional decision-making during positive face processing compared to healthy subjects. Furthermore, while both the MDD and normal groups’ brain networks were found to exhibit small-world network characteristics, the brain network of patients with depression tended to be randomized. Moreover, for patients with MDD, the centro-parietal region may lose its status as a hub in the process of facial expression identification. Together, our findings suggested that altered emotional function in MDD patients might be associated with disruptions in the topological organization of functional brain networks during emotional face recognition, which further deepened our understanding of the emotion processing dysfunction underlying MDD.

Neurophysiology

10.3389/fnhum.2024.1338765

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Citations (2)

Efficacy and Safety of Basiliximab Versus Daclizumab in Kidney Transplantation: A Meta-Analysis

Transplantation Proceedings (2015)

Zejia Sun Xiangying Du Lulu Su X.-D. Zhang Wei Wang

Daclizumab

Basiliximab

10.1016/j.transproceed.2015.08.009

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Citations (11)