Jonathan H. Epstein

EcoHealth Alliance

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Peter Daszak

EcoHealth Alliance

Ariful Islam

Charles Sturt University

Hume Field

EcoHealth Alliance

Kevin J. Olival

EcoHealth Alliance

Stephen P. Luby

Stanford University

James Hughes

EcoHealth Alliance

Emily S. Gurley

Johns Hopkins University

Melinda K. Rostal

EcoHealth Alliance

Lin‐Fa Wang

National University of Singapore

William B. Karesh

EcoHealth Alliance

Cooperative Institutions

EcoHealth Alliance

118

University of California, Davis

106

Centers for Disease Control and Prevention

Columbia University

International Centre for Diarrhoeal Disease Research

Johns Hopkins University

Wildlife Conservation Society

National Institutes of Health

University of Florida

Cornell University

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CIRCULATION OF AVIAN INFLUENZA H5N1 AND H9N2 VIRUS IN DHAMRAI AND SAVAR UPAZILA, BANGLADESH

International Journal of Infectious Diseases (2023)

Ariful Islam Shariful Islam MK Rahman Mohammad Enayet Hossain Mohammed A. Samad

Circulation (fluid dynamics)

10.1016/j.ijid.2023.04.186

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Citations (2)

Bats Are Natural Reservoirs of SARS-Like Coronaviruses

Science (2005)

Wendong Li Zheng‐Li Shi Meng Yu Wuze Ren Craig Smith

Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.

Coronavirus

Nidovirales

Sars virus

Coronaviridae

Betacoronavirus

Natural reservoir

2019-20 coronavirus outbreak

10.1126/science.1118391

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Citations (2,586)

Zoonotic potential of a novel bat morbillivirus

Research Square (Research Square) (2021)

Benhur Lee Satoshi Ikegame Jillian C. Carmichael Heather Wells Robert L. Furler

Bats are significant reservoir hosts for many viruses with zoonotic potential1. SARS-CoV-2, Ebola virus, and Nipah virus are examples of such viruses that have caused deadly epidemics and pandemics when spilled over from bats into human and animal populations2,3. Careful surveillance of viruses in bats is critical for identifying potential zoonotic pathogens. However, metagenomic surveys in bats often do not result in full-length viral sequences that can be used to regenerate such viruses for targeted characterization4. Here, we identify and characterize a novel morbillivirus from a vespertilionid bat species (Myotis riparius) in Brazil, which we term myotis bat morbillivirus (MBaMV). There are 7 species of morbilliviruses including measles virus (MeV), canine distemper virus (CDV) and rinderpest virus (RPV)5. All morbilliviruses cause severe disease in their natural hosts6-10, and pathogenicity is largely determined by species specific expression of canonical morbillivirus receptors, CD150/SLAMF111 and NECTIN412. MBaMV used Myotis spp CD150 much better than human and dog CD150 in fusion assays. We confirmed this using live MBaMV that was rescued by reverse genetics. Surprisingly, MBaMV replicated efficiently in primary human myeloid but not lymphoid cells. Furthermore, MBaMV replicated in human epithelial cells and used human NECTIN4 almost as well as MeV. Our results demonstrate the unusual ability of MBaMV to infect and replicate in some human cells that are critical for MeV pathogenesis and transmission. This raises the specter of zoonotic transmission of a bat morbillivirus.

Morbillivirus

Canine distemper

Mononegavirales

Peste-des-petits-ruminants virus

Rinderpest virus

Vero cell

10.21203/rs.3.rs-926789/v1

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Citations (14)

One Health Investigation of House Crow (Corvus splendens) Mortality Event Linked to the Potential Circulation of H5N1 Virus at Live Bird Markets in Northwestern Bangladesh

International Journal of Infectious Diseases (2022)

Ariful Islam SM Rashed Ul Islam Mohammad Enayet Hossain Md Abdus Samad Motashen Billah

Bird migration

Circulation (fluid dynamics)

10.1016/j.ijid.2021.12.265

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Citations (8)

Enhancement and creation of secondary channel habitat: Review of project performance across a range of project types and settings

AGU Fall Meeting Abstracts (2017)

Jonathan H. Epstein Peter Lind

Source

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Citations (0)

Macacine Herpesvirus 1 in Long-Tailed Macaques, Malaysia, 2009–2011

Emerging infectious diseases (2015)

Mei‐Ho Lee Melinda K. Rostal James Hughes Frankie Thomas Sitam Jimmy Lee

Macacine herpesvirus 1 (MaHV1; B virus) naturally infects macaques (Macaca spp.) and can cause fatal encephalitis in humans. In Peninsular Malaysia, wild macaques are abundant, and translocation is used to mitigate human-macaque conflict. Most adult macaques are infected with MaHV1, although the risk for transmission to persons who handle them during capture and translocation is unknown. We investigated MaHV1 shedding among 392 long-tailed macaques (M. fascicularis) after capture and translocation by the Department of Wildlife and National Parks in Peninsular Malaysia, during 2009-2011. For detection of MaHV1 DNA, PCR was performed on urogenital and oropharyngeal swab samples. Overall, 39% of macaques were shedding MaHV1 DNA; rates of DNA detection did not differ between sample types. This study demonstrates that MaHV1 was shed by a substantial proportion of macaques after capture and transport and suggests that persons handling macaques under these circumstances might be at risk for exposure to MaHV1.

Viral Shedding

10.3201/eid2107.140162

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Citations (25)

Lessons from the pandemic: Responding to emerging zoonotic viral diseases—a Keystone Symposia report

Annals of the New York Academy of Sciences (2022)

Jennifer Cable Anthony S. Fauci William E. Dowling Stephan Günther Dennis A. Bente

Abstract The COVID‐19 pandemic caught the world largely unprepared, including scientific and policy communities. On April 10–13, 2022, researchers across academia, industry, government, and nonprofit organizations met at the Keystone symposium “Lessons from the Pandemic: Responding to Emerging Zoonotic Viral Diseases” to discuss the successes and challenges of the COVID‐19 pandemic and what lessons can be applied moving forward. Speakers focused on experiences not only from the COVID‐19 pandemic but also from outbreaks of other pathogens, including the Ebola virus, Lassa virus, and Nipah virus. A general consensus was that investments made during the COVID‐19 pandemic in infrastructure, collaborations, laboratory and manufacturing capacity, diagnostics, clinical trial networks, and regulatory enhancements—notably, in low‐to‐middle income countries—must be maintained and strengthened to enable quick, concerted responses to future threats, especially to zoonotic pathogens.

Pandemic

2019-20 coronavirus outbreak

10.1111/nyas.14898

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Citations (5)

Contributors

Elsevier eBooks (2023)

Laura Adamovicz Christina A. Ahlstrom Matthew C. Allender Neil Anderson Jon M. Arnemo

10.1016/b978-0-323-82852-9.00116-7

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Citations (0)

Viral maintenance and excretion dynamics of coronaviruses within an Egyptian rousette fruit bat maternal colony: considerations for spillover

Scientific Reports (2023)

Marike Geldenhuys Noam Ross Muriel Dietrich John L. de Vries Marinda Mortlock

Abstract Novel coronavirus species of public health and veterinary importance have emerged in the first two decades of the twenty-first century, with bats identified as natural hosts for progenitors of many coronaviruses. Targeted wildlife surveillance is needed to identify the factors involved in viral perpetuation within natural host populations, and drivers of interspecies transmission. We monitored a natural colony of Egyptian rousette bats at monthly intervals across two years to identify circulating coronaviruses, and to investigate shedding dynamics and viral maintenance within the colony. Three distinct lineages were detected, with different seasonal temporal excretion dynamics. For two lineages, the highest periods of coronavirus shedding were at the start of the year, when large numbers of bats were found in the colony. Highest peaks for a third lineage were observed towards the middle of the year. Among individual bat-level factors (age, sex, reproductive status, and forearm mass index), only reproductive status showed significant effects on excretion probability, with reproductive adults having lower rates of detection, though factors were highly interdependent. Analysis of recaptured bats suggests that viral clearance may occur within one month. These findings may be implemented in the development of risk reduction strategies for potential zoonotic coronavirus transmission.

Coronavirus

Viral Shedding

Natural reservoir

10.1038/s41598-023-42938-w

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Citations (4)

Bringing Conservation Medicine into the Veterinary Curriculum: The Tufts Example

EcoHealth (2004)

GretchenE. Kaufman James G. Else Kristin Bowen Molly Anderson Jonathan H. Epstein

One Health

Specialty

10.1007/s10393-004-0112-8

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Citations (11)