Guilherme Rodolfo Souza de Araújo

Universidade Federal de Sergipe

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Ana Amélia Moreira Lira

Universidade Federal de Sergipe

Víctor Hugo Vitorino Sarmento

Universidade Federal de Sergipe

Rogéria de Souza Nunes

Universidade Federal de Sergipe

Saulo Santos Matos

Universidade Federal de Sergipe

Joyce Kelly Marinheiro da Cunha Gonsalves

Universidade Federal do Vale do São Francisco

Luiz André Santos Silva

Universidade Federal de Sergipe

Adriano Antunes de Souza Araújo

Universidade Federal de Sergipe

A. M. Costa

Universidade Federal de Sergipe

Daiane Caroline Santos Teles

Universidade Federal de Sergipe

Odeanny Vitória Azevedo Lima

Universidade Federal de Sergipe

Cooperative Institutions

Universidade Federal de Sergipe

Universidade Federal de Pernambuco

Universidade Tiradentes

Universidade Federal do Rio Grande do Norte

Instituto de Ciências Farmacêuticas

Universidade Federal do Rio Grande do Sul

Universidade de São Paulo

Instituto de Tecnologia e Pesquisa

Universidade Federal do Rio Grande

Departamento de Ciência e Tecnologia

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Microemulsions formed by PPG-5-CETETH-20 at low concentrations for transdermal delivery of nifedipine: Structural and in vitro study

Colloids and Surfaces B Biointerfaces (2022)

Guilherme Rodolfo Souza de Araújo Givalda Mendonça da Cruz Macieira Dayane Xavier de Oliveira Saulo Santos Matos Quesia Nery dos Santos

Microemulsion

Penetration (warfare)

Lipophilicity

10.1016/j.colsurfb.2022.112474

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Citations (11)

Low-surfactant microemulsion, a smart strategy intended for curcumin oral delivery

Colloids and Surfaces A Physicochemical and Engineering Aspects (2022)

Douglas Dourado Matheus Cardoso de Oliveira Guilherme Rodolfo Souza de Araújo Lucas Amaral-Machado Dayanne Lopes Porto

Microemulsion

10.1016/j.colsurfa.2022.129720

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Citations (9)

Antinociceptive activity of transdermal nanostructured surfactant-based systems containing Duloxetine Hydrochloride

Journal of Drug Delivery Science and Technology (2024)

Karoline Belém Seixas Guilherme Rodolfo Souza de Araújo Alisson Macário de Oliveira Alex José Silveira Filho Arthur Renato Oliveira Fieto Leite

Duloxetine Hydrochloride

Hydrochloride

10.1016/j.jddst.2024.106166

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Citations (0)

The therapeutic properties of Mikania glomerata Spreng. (Asteraceae)

Research Society and Development (2022)

Elane Pereira dos Santos Rafaelle de Jesus Melo Odeanny Vitória Azevedo Lima Daiane Caroline Santos Teles Rosana Moura Andrade

The Mikania glomerata Spreng is a specie found in Europe, Africa, North and South America and is commonly known as “guaco” and “guaco climber”. Many scientific studies confirm the bactericidal, anti-ophidic, antifungal, anti-inflammatory, antimalarial, and bronchodilator pharmacological activities. These studies aim to contribute to new research, report the phytotherapy aspects and describe the therapeutical properties of Mikania glomerata. This study is an integrative review with a descriptive approach. Were found during the study that the guaco therapeutical properties are diverse, such as: antiasthmatic, tonic, antipyretic, expectorant, appetite stimulant, anti-influenza, antirheumatic, soothing, healing, diuretic, emollient, fluidizing, bacterial growth inhibitor, antiallergic, antifungal, antioxidant, anthelmintic. Thereby, the analyzed texts show, besides the properties mentioned above, an expressive performance on duodenal and stomach ulcers, infectious diseases such as tonsillitis and oropharyngeal inflammation, influenzas, and upper airway infections (UAI), usually known as cold. Thus, is essential to highlight the value of the medicinal use of this compound, in a way to accentuate their benefits for the clinical improvement of various conditions that currently affect patients. However, given the data that were shown previously, as well as the limited number of studies, it is fundamental to carry out more research to define more safely the therapeutic properties of the M. glomerata, in addition to showing the long-term effects of the use of your phytotherapic and safe doses, such as side effects.

Expectorant

Siddha

Pharmacopoeia

10.33448/rsd-v11i14.36185

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In situ microemulsion-gel obtained from bioadhesive hydroxypropyl methylcellulose films for transdermal administration of zidovudine

Colloids and Surfaces B Biointerfaces (2019)

Guilherme Rodolfo Souza de Araújo Leandro de Oliveira Porfírio Luiz André Santos Silva Danielle Gomes Santana Paula Ferreira Barbosa

Microemulsion

Dispersity

10.1016/j.colsurfb.2019.110739

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Citations (18)

Hesperetin-Based Hydrogels Protect the Skin against UV Radiation-Induced Damage

AAPS PharmSciTech (2022)

Tatianny de Araújo Andrade Luana Heimfarth Danillo Menezes dos Santos Viviane Martins Rebello dos Santos Ricardo Luiz Cavalcanti de Albuquerque Júnior

Hesperetin

Erythema

Photoaging

10.1208/s12249-022-02323-8

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Citations (8)

Lyotropic liquid crystal mesophases as transdermal delivery systems for lipophilic drugs: A comparative study

International Journal of Pharmaceutics (2023)

Guilherme Rodolfo Souza de Araújo Odeanny Vitória Azevedo Lima João Pedro Barreto Neujahr Saulo Santos Matos Thalisson Amorim de Souza

Small-angle X-ray scattering

Lyotropic liquid crystal

Lyotropic

Polarized light microscopy

10.1016/j.ijpharm.2023.122853

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Citations (7)

Development of Microemulsions Containing Eremanthus Erythropappus Essential Oil for the Topical Treatment of Cutaneous Leishmaniasis

Quesia Nery dos Santos Ana Amélia Moreira Lira Daiane Caroline Santos Teles Guilherme Rodolfo Souza de Araújo Luiz André Santos Silva

This study aimed to develop microemulsions (MEs) containing essential oil of Eremanthus erythropappus (EEEO) for the topical treatment of cutaneous leishmaniasis. Initially, pseudoternary phase diagrams were developed using EEEO as the oil phase, Eumulgin® CO 40 as the surfactant, Olivem® 300 or Polymol® HE as the co-surfactant, and distilled water as the aqueous phase. It selected and characterized the transparent liquid systems (TLS) containing 5% of EEEO obtained with the lowest concentrations of surfactant, one formulation of each diagram. As a result, the selected formulations showed isotropy, Newtonian behavior, pH ranging from 6.5 to 6.9, and electrical conductivity from 269 to 519 µS. The formulations also presented droplet size and polydispersity index below 25 nm and 0.3, respectively, confirming the obtainment of MEs. The MEs achieved a 2.5-fold increase in the flux and skin-permeated amount of bisabolol. According to the data obtained from growth inhibition (IC50) of promastigotes, MEs showed higher activity against L. amazonensis, L. brasiliensis, and L. major compared to EEEO alone. MEs also showed antileishmanial activity against intracellular amastigotes of L. amazonensis, with IC50 50 times lower than free EEEO and high selectivity index up to 15. Therefore, the systems obtained are favorable to topical administration, with significant antileishmania activity against promastigotes and amastigotes, promising for the CL treatment.

Microemulsion

10.2139/ssrn.4425463

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Microemulsion systems to enhance the transdermal permeation of ivermectin in dogs: A preliminary in vitro study

Research in Veterinary Science (2020)

Micheline Machado Isabella Lima Dantas Juliana Gouveia Galvão Alyne Dantas Lima Joyce Kelly Marinheiro da Cunha Gonsalves

Microemulsion

Isopropyl myristate

10.1016/j.rvsc.2020.08.009

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Citations (11)

Evaluation of the influence of calcium chloride on the behavior of phases of nanosystems applied in the larvicidal control of Aedes aegypti

Research Society and Development (2022)

Adriana de Jesus Santos Nathália Araújo Macêdo Marcos Rafael das Chagas Mendonça Sócrates Cabral de Holanda Cavalcanti Víctor Hugo Vitorino Sarmento

Systems stabilized by surfactants in order to incorporate different substances at their interfaces, such as hydrophilic polymers and active compounds, are systems capable of establishing vector control of Aedes aegypti. The system was obtained through the surface tension of PPG-5-CETETH-20/calcium chloride dispersion at concentrations of 0.2%, 0.4%, 0.8%, 1% and 2%, determining the CMC of each sample. Then, a binary study was performed and the system structures were evaluated by Polarized Light Microscopy (PLM) and rheological analysis. Biological analysis was performed to assess the mean lethal concentration (LC50) against Aedes aegypti larvae and toxicity to non-target organisms in Artemia salina. In this sense, the objective of this work was to evaluate the influence of calcium chloride on the behavior of phases and on the biological activity of formulations based on the self-aggregation of surfactants, an alternative larval insecticide to be used as a replacement for larval insecticides already on the market.

Artemia salina

10.33448/rsd-v11i3.26115

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Citations (0)