Shintaro Hashiba

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Noriyuki Takabatake

Obihiro University of Agriculture and Veterinary Medicine

Masashi Okamura

Obihiro University of Agriculture and Veterinary Medicine

Ikuo Igarashi

Obihiro University of Agriculture and Veterinary Medicine

Sabine Bork

Laboratoire National de Santé

Naoaki Yokoyama

Obihiro University of Agriculture and Veterinary Medicine

Yuzuru Ikehara

Chiba University

直横

直明横山

Kazuya Nakamura

Sophia University

郁五

郁男五十嵐

Cooperative Institutions

Obihiro University of Agriculture and Veterinary Medicine

Photonics Electronics Technology Research Association

Kitasato University

University of Sadat City

Qinghai University

Yamagata University

Chiba University

National Institute of Advanced Industrial Science and Technology

Tzu Chi University

NTL Institute for Applied Behavioral Science

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FUCOIDAN INHIBITS THE IN VITRO GROWTH OF BABESIA BOVIS

Journal of protozoology research (2004)

Noriyuki Takabatake Shintaro Hashiba Sabine Bork Masashi Okamura Naoaki Yokoyama

Babesia bovis

Fucoidan

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ASEXUAL GROWTH OF BABESIA BOVIS IS INHIBITED BY SPECIFIC SULFATED GLYCOCONJUGATES

Journal of Parasitology (2007)

Sabine Bork Naoaki Yokoyama Shintaro Hashiba Kazuya Nakamura Noriyuki Takabatake

In the present study, inhibitory effects of several sulfated and nonsulfated glycoconjugates were evaluated on the in vitro asexual growth of Babesia bovis. Among the selected sulfated glycoconjugates, dextran sulfate, heparin, heparan sulfate, fucoidan, and chondroitin sulfate B strongly inhibited the parasitic growth, and all but chondroitin sulfate B induced a significant accumulation of extracellular merozoites in culture. In contrast, chondroitin sulfate A, keratan sulfate, and protamine sulfate, as well as nonsulfated dextran and hyaluronic acid, did not influence the growth. These findings indicate that the asexual growth of B. bovis merozoites is inhibited by specific sulfated glycoconjugates, possibly providing us with an important insight into the molecular interaction(or interactions) during the process of the erythrocyte invasion by B. bovis merozoites.

Babesia bovis

Glycoconjugate

Keratan sulfate

Fucoidan

Protamine sulfate

Chondroitin

10.1645/ge-1166.1

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Citations (4)