Grape seed extracts were more cytotoxic than grape peel extracts. Methanol and 70% methanol extracts of grape seed selectively killed two human oral tumor cell lines, more efficiently than human gingival fibroblasts. ESR spectroscopy revealed that these extracts produced radicals under alkaline conditions and enhanced the radical intensity of sodium ascorbate at higher concentrations. On the other hand, lower concentration of these extracts slightly reduced the radical intensity of sodium ascorbate, and scavenged superoxide anion, generated by hypoxanthine and xanthine oxidase reaction. These properties of grape seed extracts suggest their possible application for cancer prevention.

Sodium ascorbate

Grape seed extract

Hypoxanthine

Hydroxyl radical

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Citations (34)

Both NUP98/TOP1 and TOP1/NUP98 transcripts are detected in a de novo AML with t(11;20)(p15;q11)

Genes Chromosomes and Cancer (2003)

Satsuki Iwase Nobutake Akiyama Tetsuaki Sekikawa Shinobu Saito Yasuhiro Arakawa

Abstract The NUP98 gene is involved in several chromosomal abnormalities associated with acute leukemia. The recurrent t(11;20)(p15;q11) chromosomal translocation results in generation of the NUP98/TOP1 chimeric gene. This abnormality has been observed primarily in therapy‐related leukemias, and TOP1/NUP98 transcripts have not been demonstrated. We describe a case of de novo acute myeloid leukemia with t(11;20)(p15;q11), with no known history of exposure to chemicals. The translocation occurred in intron 13 of NUP98 and intron 7 of TOP1 , as in the three previously reported cases. The breakpoint in NUP98 was exactly the same as that found in a previously reported case. In addition, a reciprocal TOP1/NUP98 transcript was detected for the first time in our patient. © 2003 Wiley‐Liss, Inc.

Breakpoint

10.1002/gcc.10239

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Citations (18)

Cytostatic concentrations of anticancer agents do not affect telomerase activity of leukaemic cells in vitro

European Journal of Cancer (1999)

Masaharu Akiyama Junko Horiguchi‐Yamada Shinobu Saito Y Hoshi Osamu Yamada

Daunorubicin

Propidium iodide

K562 cells

10.1016/s0959-8049(98)00365-7

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Citations (45)

A Case of Hemochromatosis in which Laparoscopy was Useful for Differentiation from a Hepatocellular Tumor

Digestive Endoscopy (1994)

Susumu Shiomi Tetsuo Kuroki Tadashi Ueda Hiroki Sakaguchi Shuhei Nishiguchi

Abstract: The case of a 54‐year‐old man with hemochromatosis who developed cirrhosis of the liver and hepatocellular tumor is discussed. Before laparoscopy, the possibility of hepatocellular carcinoma was not ruled out by imaging tests only. Laparoscopy revealed a tumor, 60 mm in diameter, protruding from the lower portion of the left lobe of the liver. The tumor was biopsied during laparoscopy, and tentatively identified as a regeneration nodule. Laparoscopy is useful for the definite diagnosis of hepatocellular tumors.

Nodule (geology)

10.1111/j.1443-1661.1994.tb00377.x

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Abnormal Wrist Sagittal Kinematics in Gymnasts With Dorsal Wrist Pain: A New Syndrome

The American Journal of Sports Medicine (2024)

Takahiro Sekiguchi Shinobu Saito Takahiro Ogura Akihiro Tsuchiya Hideaki Shiratsuchi

Background: The pathology of dorsal wrist pain in gymnasts without abnormal radiographic findings remains unclear. Purpose/Hypothesis: The purpose of this study was to identify abnormal wrist sagittal kinematics in gymnasts with dorsal wrist pain. It was hypothesized that gymnasts with dorsal wrist pain would show abnormal sagittal kinematics with reversible hypermobility of the intercarpal joint. Study Design: Controlled laboratory study. Methods: Participants included 19 wrists in male gymnasts with dorsal wrist pain, 18 wrist in male gymnasts without wrist pain, and 20 adult men without a history of wrist pain. Magnetic resonance imaging (T2-weighted sagittal images) findings at 0°, 30°, 60°, and 90° of wrist extension were used in kinematic analysis. The angles and translations of the radiolunate, capitolunate, and third carpometacarpal joint were measured and compared between the 3 groups. Results: At 90° of wrist extension, gymnasts with dorsal wrist pain had a significantly lower radiolunate joint angle (28.70°± 6.28° vs 36.19°± 7.81°; P = .020) and a significantly higher capitolunate joint angle (57.99°± 6.15° vs 50.50°± 6.98°; P = .004) and distal translation (1.17 ± 0.50 mm vs 0.46 ± 0.62 mm; P = .002) than gymnasts without dorsal wrist pain. Conclusion: Gymnasts with dorsal wrist pain showed abnormal wrist sagittal kinematics. These novel findings may facilitate understanding of dorsal wrist pain, which can be recognized as a new syndrome termed “gymnast’s lunate dyskinesia.”

Wrist pain

10.1177/03635465231204361

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Radial head dislocation with ulnar plastic deformation in children: An osteotomy within the middle third of the ulna

Journal of Shoulder and Elbow Surgery (2008)

Sakae Sano Tomoyuki Rokkaku Katsumi Imai Shinobu Saito Yoshihiro Abe

Ulnar deviation

Kirschner wire

10.1016/j.jse.2008.03.007

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Citations (9)

Effect of Administration of Sairei-to on Painful Muscle Cramps in Patients with Chronic Liver Disease, Especially with Cirrhosis of the Liver.

Kampo Medicine (1993)

Masahiro Nakao Tokan HIRANO Sadahiko Hiratani Masayoshi Fujisawa Shinobu Saito

慢性肝疾患とくに肝硬変にみられる硬直性有痛性筋痙攣 (こむら返り) に対して柴苓湯5.4～8.1g/日の投与を行った。筋痙攣が全く消失した3例を含めて7例中6例において筋痙攣の頻度の明らかな減少と, 筋痙攣に伴う疼痛の程度の改善を認めた。なお, 有効例においては, いずれも, 柴苓湯投与後2週以内に十分な効果の発現をみている。有効例中著効を示した一例を呈示する。腹部から下肢に至る強い筋痙攣を頻発する71歳, 女性の肝硬変例に柴苓湯の投与を行った。投与開始翌日には, 筋痙攣の消失をみた。その後, 患者自身の判断で服薬を中止したところ, 再び筋痙攣が出現した。柴苓湯の服用を再開すると, 投与再開翌日には筋痙攣は消失した。これらの成績より, 柴苓湯の効果は疑う余地がなく, 慢性肝疾患とくに肝硬変にみられる筋痙攣に対する柴苓湯の投与が非常に有効なことがわかった。

Muscle cramp

Chronic liver disease

Liver disease

10.3937/kampomed.43.539

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Citations (3)

[The relationship between the amount of hepatitis C virus quantified by multi-cyclic RT-PCR (MRT-PCR) and several stage of the chronic liver diseases].

PubMed (1992)

Narihiro Ishiyama Kazuhiko Katayama Norikuni Ishimi Shuhei Takahashi Hisayoshi Igarashi

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