V. F. Newhouse

National Institute of Allergy and Infectious Diseases

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W. D. Sudia

Center for Disease Control

Willy Burgdorfer

National Institute of Allergy and Infectious Diseases

Joseph E. McDade

Centers for Disease Control and Prevention

Darlene Miller

University of Miami

Roy W. Chamberlain

University of Glasgow

C. H. Calisher

Colorado State University

David B. Lackman

Alaska Department of Health and Social Services

J. Johnston

Sprint (United States)

Lawrence J. D’Angelo

National Hospital

J. A. McKiel

University of Fredericton

Cooperative Institutions

Centers for Disease Control and Prevention

United States Public Health Service

National Institutes of Health

National Center for Infectious Diseases

United States Department of Health and Human Services

National Institute of Allergy and Infectious Diseases

National Security Agency

Center for Disease Control

Alabama Department of Public Health

United States Department of State

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Evidence of Rickettsia Prowazekii Infections in the United States

American Journal of Tropical Medicine and Hygiene (1980)

Joseph E. McDade Charles C. Shepard Martha A. Redus V. F. Newhouse J. David Smith

From January 1976 through January 1979 serum specimens from 1,575 individuals were received at the Center for Disease Control and tested for antibodies to rickettsiae. Of these, sera from eight persons gave serological results indicative of recent infections with epidemic typhus rickettsiae (Rickettsia prowazekii). Five of the persons were from Georgia, and one each was from Tennessee, Pennsylvania and Massachusetts. The illnesses occurred during the winter, chiefly in persons living in a rural environment. The clinical picture was compatible with louse-borne epidemic typhus. There was no apparent contact with human body or head lice, and no cases occurred in patient contacts, indicating that infection was not associated with the classic man-louse-man cycle of epidemic typhus. Two of the eight patients had contact with flying squirrels, suggesting that they became infected from this known extrahuman reservoir of R. prowazekii.

Rickettsia prowazekii

10.4269/ajtmh.1980.29.277

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Citations (87)

Rocky Mountain spotted fever in Georgia, 1961-75: analysis of social and environmental factors affecting occurrence.

PubMed (1986)

V. F. Newhouse K Choi Robert C. Holman S B Thacker Lawrence J. D’Angelo

For the period of 1961 through 1975, 10 geographic and sociologic variables in each of the 159 counties of Georgia were analyzed to determine how they were correlated with the occurrence of Rocky Mountain spotted fever (RMSF). Combinations of variables were transformed into a smaller number of factors using principal-component analysis. Based upon the relative values of these factors, geographic areas of similarity were delineated by cluster analysis. It was found by use of these analyses that the counties of the State formed four similarity clusters, which we called south, central, lower north and upper north. When the incidence of RMSF was subsequently calculated for each of these regions of similarity, the regions had differing RMSF incidence; low in the south and upper north, moderate in the central, and high in the lower north. The four similarity clusters agreed closely with the incidence of RMSF when both were plotted on a map. Thus, when analyzed simultaneously, the 10 variables selected could be used to predict the occurrence of RMSF. The most important variables were those of climate and geography. Of secondary, but still major importance, were the changes over the 15-year period in variables associated with humans and their environmental alterations. Detailed examination of these factors has permitted quantitative evaluation of the simultaneous impacts of the geographic and sociologic variables on the occurrence of RMSF in Georgia. These analyses could be updated to reflect changes in the relevant variables and tested as a means of identifying new high risk areas for RMSF in the State. More generally, this method might be adapted to clarify our understanding of the relative importance of individual variables in the ecology of other diseases or environmental health problems.

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A Comparison of the Complement Fixation, Indirect Fluorescent Antibody, and Microagglutination Tests for the Serological Diagnosis of Rickettsial Diseases

American Journal of Tropical Medicine and Hygiene (1979)

V. F. Newhouse Charles C. Shepard Martha A. Redus T. Tzianabos Joseph E. McDade

Three techniques for the serological diagnosis of Rocky Mountain spotted fever were compared by testing 417 sera from 178 patients who very probably did not have rickettsial infections and 88 sera from 41 patients who very probably had Rocky Mountain spotted fever (SF). The techniques were complement fixation (CF), indirect fluorescent antibody (IFA), and microagglutination (MA). To avoid possible degradation during unnecessary purification, the antigens were prepared by methods that were as simple as possible. In the CF tests of 417 sera from patients with nonrickettsial diseases there was only one titer of 8 and none at higher dilutions, whereas with the IFA and MA tests 4-8% of the sera reacted with SF antigens and 4-20% reacted with murine typhus (MT) antigens; the evidence indicated that these reactions were not caused by specific rickettsial antibody. With the SF sera, it could be seen that the IFA test was the most sensitive and the MA test was the least sensitive at each interval after infection. Moreover, the IFA results showed the least number of confusing cross-reactions with MT antigens and the MA test showed the most. The relative advantages of the three tests in serodiagnosis of rickettsial diseases are discussed.

Complement fixation test

10.4269/ajtmh.1979.28.387

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Citations (76)

Field and laboratory studies on the hosts and vectors of the Snowshoe hare strain of California virus.

Mosquito news (1971)

V. F. Newhouse Willy Burgdorfer D. Corwin

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Snowshoe hare

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Citations (11)

ISOLATION OF CALIFORNIA ENCEPHALITIS VIRUS FROM THE BLOOD OF A SNOWSHOE HARE (LEPUS AMERICANUS) IN WESTERN MONTANA1

American Journal of Epidemiology (1961)

Willy Burgdorfer V. F. Newhouse Leo A. Thomas

Journal Article ISOLATION OF CALIFORNIA ENCEPHALITIS VIRUS FROM THE BLOOD OF A SNOWSHOE HARE (LEPUS AMERICANUS) IN WESTERN MONTANA Get access WILLY BURGDORFER, WILLY BURGDORFER Search for other works by this author on: Oxford Academic PubMed Google Scholar VERNE F. NEWHOUSE, VERNE F. NEWHOUSE Search for other works by this author on: Oxford Academic PubMed Google Scholar LEO A. THOMAS LEO A. THOMAS Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 73, Issue 3, May 1961, Pages 344–349, https://doi.org/10.1093/oxfordjournals.aje.a120193 Published: 01 May 1961 Article history Received: 23 January 1961 Published: 01 May 1961

Snowshoe hare

Isolation

Virus isolation

10.1093/oxfordjournals.aje.a120193

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Citations (35)

California group arbo-viruses: isolations from mosquitoes in North America.

Mosquito news (1971)

W. D. Sudia V. F. Newhouse C. H. Calisher Roy W. Chamberlain

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Citations (65)

DDT Use and the Incidence of Rocky Mountain Spotted Fever: a Hypothesis 1

Environmental Entomology (1979)

V. F. Newhouse Lawrence J. D’Angelo Robert C. Holman

Journal Article DDT Use and the Incidence of Rocky Mountain Spotted Fever: a Hypothesis Get access Verne F. Newhouse, Verne F. Newhouse 2 Research Entomologist, Virology Division, Bureau of Laboratories Search for other works by this author on: Oxford Academic PubMed Google Scholar Lawrence J. D'Angelo, Lawrence J. D'Angelo 3 Epidemic Intelligence Service Officer, Viral Diseases Division, Bureau of Epidemiology Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert C. Holman Robert C. Holman 4 Biostatistician, Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control, Public Health Service, U.S. Department of Health, Education and Welfare, Atlanta, GA 30333 Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 8, Issue 5, 1 October 1979, Pages 777–781, https://doi.org/10.1093/ee/8.5.777 Published: 01 October 1979 Article history Received: 28 February 1979 Published: 01 October 1979

Officer

Atlanta

Disease Control

10.1093/ee/8.5.777

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Citations (4)

Natural History of Rickettsia Rickettsii

Annual Review of Microbiology (1986)

Joseph E. McDade V. F. Newhouse

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More

Rickettsia rickettsii

Coronavirus

Betacoronavirus

Highly pathogenic

10.1146/annurev.mi.40.100186.001443

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Citations (179)

ECOLOGY OF ROCKY MOUNTAIN SPOTTED FEVER IN WESTERN MONTANA

American Journal of Epidemiology (1962)

Willy Burgdorfer V. F. Newhouse Edgar G. Pickens David B. Lackman

Journal Article ECOLOGY OF ROCKY MOUNTAIN SPOTTED FEVER IN WESTERN MONTANA: I.ISOLATION OF RICKETTSIA RICKETTSIIFROM WILD MAMMALS Get access WILLY BURGDORFER, WILLY BURGDORFER From U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Mont Search for other works by this author on: Oxford Academic PubMed Google Scholar VERNE F. NEWHOUSE, VERNE F. NEWHOUSE From U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Mont Search for other works by this author on: Oxford Academic PubMed Google Scholar EDGAR G. PICKENS, EDGAR G. PICKENS From U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Mont Search for other works by this author on: Oxford Academic PubMed Google Scholar DAVID B. LACKMAN DAVID B. LACKMAN From U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Mont Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 76, Issue 3, November 1962, Pages 293–301, https://doi.org/10.1093/oxfordjournals.aje.a120284 Published: 01 November 1962 Article history Received: 19 July 1962 Published: 01 November 1962

10.1093/oxfordjournals.aje.a120284

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Citations (14)

The Culex pipiens complex in southern Indiana.

Mosquito news (1965)

V. F. Newhouse R. E. Siverly

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