Małgorzata Myśliwiec

Gdańsk Medical University

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Agnieszka Szadkowska

Medical University of Lodz

Przemysława Jarosz‐Chobot

Medical University of Silesia

Wojciech Młynarski

Medical University of Lodz

Katarzyna Zorena

Gdańsk Medical University

Jolanta Myśliwska

Gdańsk Medical University

Agnieszka Brandt

Gdańsk Medical University

Maciej T. Małecki

Jagiellonian University

Wojciech Fendler

Medical University of Lodz

Anna Balcerska

Gdańsk Medical University

Leszek Czupryniak

Medical University of Warsaw

Cooperative Institutions

European Atherosclerosis Society

262

Gdańsk Medical University

207

Medical University of Silesia

Medical University of Warsaw

Jagiellonian University

Medical University of Lodz

Medical University of Białystok

Poznan University of Medical Sciences

Istituti di Ricovero e Cura a Carattere Scientifico

University Clinical Centre

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Novel methods of continuous glucose monitoring and telehealth in the improvement of diabetes care: a narrative review

Archives of Medical Science (2021)

Jerzy Hohendorff Leszek Czupryniak Grzegorz Dzida Piotr Fichna Przemysława Jarosz‐Chobot

Standard markers of glycaemic control, such as glycated haemoglobin (HbA1c) and self-measurement of blood glucose (SMBG), have proven insufficient. HbAc1 is an averaged measurement that does not give information about glucose variability. SMBG provides limited, intermittent blood glucose (BG) values over the day and is associated with poor compliance because of invasiveness of the method and social discomfort. In contrast to glucometers, continuous glucose monitoring (CGM) devices do not require finger-stick blood samples, but instead measure BG via percutaneous or subcutaneous sensors. The immediate benefits of CGM include prevention of hypoglycaemia or hyperglycaemia, and automated analysis of long-term glycaemic data enables reliable treatment adjustments. This review describes the principles of CGM and how CGM data have changed diabetes treatment standards by introducing new glycaemic control parameters. It also compares different CGM devices and examines how the convenience of sharing CGM data in telehealth applies to the current coronavirus-19 pandemic.

Telehealth

Blood Glucose Self-Monitoring

Glycated haemoglobin

Pandemic

Blood glucose monitoring

10.5114/aoms/139025

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Citations (1)

Steroid-induced diabetes in the paediatric population

Pediatric Endocrinology Diabetes and Metabolism (2018)

Marcelina Drucis Ninela Irga‐Jaworska Małgorzata Myśliwiec

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Drucis M, Irga-Jaworska N, Myśliwiec M. Steroid-induced diabetes in the paediatric population. Pediatric Endocrinology Diabetes and Metabolism. 2018;24(3):136-139. doi:10.5114/pedm.2018.80995. APA Drucis, M., Irga-Jaworska, N., & Myśliwiec, M. (2018). Steroid-induced diabetes in the paediatric population. Pediatric Endocrinology Diabetes and Metabolism, 24(3), 136-139. https://doi.org/10.5114/pedm.2018.80995 Chicago Drucis, Marcelina, Ninela Irga-Jaworska, and Małgorzata Myśliwiec. 2018. "Steroid-induced diabetes in the paediatric population". Pediatric Endocrinology Diabetes and Metabolism 24 (3): 136-139. doi:10.5114/pedm.2018.80995. Harvard Drucis, M., Irga-Jaworska, N., and Myśliwiec, M. (2018). Steroid-induced diabetes in the paediatric population. Pediatric Endocrinology Diabetes and Metabolism, 24(3), pp.136-139. https://doi.org/10.5114/pedm.2018.80995 MLA Drucis, Marcelina et al. "Steroid-induced diabetes in the paediatric population." Pediatric Endocrinology Diabetes and Metabolism, vol. 24, no. 3, 2018, pp. 136-139. doi:10.5114/pedm.2018.80995. Vancouver Drucis M, Irga-Jaworska N, Myśliwiec M. Steroid-induced diabetes in the paediatric population. Pediatric Endocrinology Diabetes and Metabolism. 2018;24(3):136-139. doi:10.5114/pedm.2018.80995.

10.5114/pedm.2018.80995

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The Impact of Metabolic Memory on Immune Profile in Young Patients with Uncomplicated Type 1 Diabetes

International Journal of Molecular Sciences (2024)

Jolanta Neubauer‐Geryk Melanie Wielicka Małgorzata Myśliwiec Katarzyna Zorena Leszek Bieniaszewski

Metabolic memory refers to the long-term effects of achieving early glycemic control and the adverse implications of high blood glucose levels, including the development and progression of diabetes complications. Our study aimed to investigate whether the phenomenon of metabolic memory plays a role in the immune profile of young patients with uncomplicated type 1 diabetes (T1D). The study group included 67 patients with uncomplicated type 1 diabetes with a mean age of 15.1 ± 2.3 years and a minimum disease duration of 1.2 years. The control group consisted of 27 healthy children and adolescents with a mean age of 15.1 ± 2.3 years. Patients were divided into three groups according to their HbA1c levels at the onset of T1D, and the average HbA1c levels after one and two years of disease duration. The subgroup A1 had the lowest initial HbA1c values, while the subgroup C had the highest initial HbA1c values. Cytokine levels (including TNF-α, IL-35, IL-4, IL-10, IL-18, and IL-12) were measured in all study participants. Our data analysis showed that subgroup A1 was characterized by significantly higher levels of IL-35 and IL-10 compared to all other groups, and significantly higher levels of IL-4 compared to group B. Additionally, a comparative analysis of cytokine levels between the groups of diabetic patients and healthy controls demonstrated that subgroup A1 had significantly higher levels of anti-inflammatory cytokines. The lipid profile was also significantly better in subgroup A1 compared to all other patient groups. Based on our findings, it appears that an inflammatory process, characterized by an imbalance between the pro- and anti-inflammatory cytokines, is associated with poor glycemic control at the onset of diabetes and during the first year of disease duration. These findings also suggest that both metabolic memory and inflammation contribute to the abnormal lipid profile in patients with type 1 diabetes.

Subgroup analysis

Lipid Profile

Metabolic control analysis

10.3390/ijms25063190

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Citations (2)

[Interleukin 12 as an anti-angiogenic mediator in type 1 diabetic children].

PubMed (2007)

Katarzyna Zorena Jolanta Myśliwska Małgorzata Myśliwiec Anna Balcerska Paweł Lipowski

The objective of the study was to analyse levels IL-12 and to relate the findings to the clinical course of type 1 diabetes mellitus (DM1).We examined a group of 102 children with DM1 and 39 healthy children (as the control). All the children with DM1 had their daily urine albumin excretion, HbA1c, C-peptide measured, 24hrs blood pressure monitoring and ophthalmologic examination. In accordance to the ophthalmologic examination and level IL-12 in the serum the diabetic children were divided into 3 groups: group A: IL-12>0 pg/ml; group B: IL-12=0 pg/ml; group C: IL-12=0 pg/ml and IL12>0 pg/ml. Serum levels of IL-12 and TNFalpha were measured by the immunoenzymatic ELISA method, Quan-tikine High Sensitivity Human by R&D Systems (USA).Children of group A were characterized by significantly high level of IL-12 and by the absence of TNFalpha as compared with the children of group B, who had undetectable IL-12 along with high TNFalpha level. Additionally, children of group A had significantly lower urine albumin excretion and had only developed retinopathy. However, the children of group B not only had retinopathy, nephropathy but also arterial hypertension. The patients of group A were also analysed against the children of group C, who were characterized by high IL-12 level and some of them had also detectable TNFalpha, but without retinopathy and nephropathy.The results of our study imply the existence of balance between IL-12 and TNFalpha in type 1 DM children, which seems to warrant the stage of disease without diabetic complications. However, the IL-12 domination tends to prevent or delay nephropathy development but does not protect from retinopathy.

Group B

Group A

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Citations (2)

Analysis of chosen polymorphisms in FoxP3 gene in children and adolescents with autoimmune thyroid diseases

Endocrine Abstracts (2014)

Artur Bossowski Hanna Borysewicz-Sańczyk Natalia Wawrusiewicz‐Kurylonek Mieczysław Szalecki Beata Wikiera

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

10.1530/endoabs.35.p1057

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Citations (5)

Pediatric diabetes care: inpatient care in the Maps of Health Needs of Poland in 2014

Clinical Diabetology (2019)

Artur Myśliwiec Przemysława Jarosz‐Chobot Małgorzata Myśliwiec Krzysztof Strojek Paweł Piątkiewicz

Provision of care to patients with diabetes mellitus is a considerable challenge to health policy due to the increasing number of new cases, both in adults and in children. In Poland, hospital care provided to children with diabetes mellitus is centralised and most services are provided by university and provincial hospitals. In spite of the above the structure of the services provided varies widely from province to province, both in terms of the number of hospitalisations per 100,000 children, net migration rate, length of stay, and percentage of hospitalisations for acute complications.

10.5603/dk.2018.0028

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Cukrzyca typu 1 u dzieci i młodzieży

Analiza Przypadków Pediatria (2021)

Magdalena Ilkowska Anna Wołoszyn‐Durkiewicz Małgorzata Myśliwiec

Czasopismo jest skierowane do pediatrów. W każdym numerze publikowane są bogato ilustrowane opisy przypadków, dokładne analizy postępowania – od diagnozy do efektu terapii – wraz ze wskazaniem błędów, konkretne rozwiązania i wytyczne stosowane i rekomendowane przez praktyków oraz podpowiedzi ekspertów. Opisy przypadków publikowane są w następujących działach: · Stany nagłe · Z praktyki pediatry · Alergie · Szczepienia · Odżywianie, zalecenia dietetyczne · Higiena i pielęgnacja · Prawo, psychologia, dokumentacja

10.53270/app2021.4.004

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Decreased angiogenin concentration in vitreous and serum in proliferative diabetic retinopathy

Microvascular Research (2011)

Natalia Marek-Trzonkowska Krystyna Raczyńska Janusz Siebert Małgorzata Myśliwiec Katarzyna Zorena

Angiogenin

Pathogenesis

10.1016/j.mvr.2011.04.006

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Citations (23)

Genetic variation in C-reactive protein (CRP) gene is associated with retinopathy and hypertension in adolescents with type 1 diabetes

Cytokine (2022)

Bartosz Słomiński Martyna Jankowiak Agata Maciejewska Maciej Studziński Aleksandra Mączyńska

Genetic predisposition

10.1016/j.cyto.2022.156025

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Citations (1)

Modulators of K⁺ Channels in Diabetology

BENTHAM SCIENCE PUBLISHERS eBooks (2012)

Małgorzata Myśliwiec

There is one specific type of K+ channels profoundly involved in regulation of release of hormone insulin and inextricably connected to pathogenesis of diabetes mellitus. It is ATP-sensitive K+ channel (KATP). Recently, along with advances in genetic testing, a growing number of permanent neonatal diabetes (PND) has been diagnosed, which is a monogenic form of diabetes of even earlier onset than maturity onset diabetes of the young (MODY). Neonatal diabetes can result from mutations in Kir6.2 or sulfonylurea receptor (SUR1) subunits of the ATP-sensitive K+ channel. The pathogenesis is based on the mechanism of permanent activation and wide opening of the KATP potassium channel of the β-cells. An important and interesting feature of the disease clinical picture is sustained therapeutic response to sulfonylureas in the treatment of neonatal diabetes caused by mutation in the KCNJ11 and ABCC8 genes. Mechanism of action of this class of medicines involves interaction with the SUR1 subunit of the KATP channel in the β cell. However, there are some types of neonatal diabetes which fail to respond to the sulfonylurea therapy. An example of this is the most severe phenotype of neonatal diabetes accompanied with disorders of the nervous system, muscle weakness and psychomotor development delay, which is a so-called DEND syndrome. Analogs of GLP-1 and antagonist of GLP-1 receptor may provide a new way of treatment in KATP dependent disorders. These hormones may modulate the beta cells response by influencing KATP channels and cAMP independently.

Sulfonylurea receptor

Sulfonylurea

Kir6.2

Pathogenesis

10.2174/978160805235611201010043

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