Quentin N. Wilson

Wake Forest University

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Magan Wells

Wake Forest University

Ashley Davis

University of Maryland, Baltimore

Christina H. Sherrill

University of North Carolina at Asheville

Kylie Kavanagh

Wake Forest University

Roshonda B. Jones

North Carolina Agricultural and Technical State University

S. Tyler Aycock

Wake Forest University

Gayathriy Balamayooran

Wake Forest University

Nancy D. Kock

Wake Forest University

Hannah Atkins

University of North Carolina at Chapel Hill

David L. Caudell

Wake Forest University

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Wake Forest University

Atrium Health Wake Forest Baptist

University of North Carolina at Chapel Hill

University of California, Los Angeles

University of North Carolina at Charlotte

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University of North Carolina Health Care

Howard Hughes Medical Institute

University of Florida

University of Southern California

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Greater Microbial Translocation and Vulnerability to Metabolic Disease in Healthy Aged Female Monkeys

Scientific Reports (2018)

Quentin N. Wilson Magan Wells Ashley Davis Christina H. Sherrill Matthew C. B. Tsilimigras

Monkeys demonstrate gastrointestinal barrier dysfunction (leaky gut) as evidenced by higher biomarkers of microbial translocation (MT) and inflammation with ageing despite equivalent health status, and lifelong diet and environmental conditions. We evaluated colonic structural, microbiomic and functional changes in old female vervet monkeys (Chlorocebus aethiops sabeus) and how age-related leaky gut alters responses to Western diet. We additionally assessed serum bovine immunoglobulin therapy to lower MT burden. MT was increased in old monkeys despite comparable histological appearance of the ascending colon. Microbiome profiles from 16S sequencing did not show large differences by age grouping, but there was evidence for higher mucosal bacterial loads using qPCR. Innate immune responses were increased in old monkeys consistent with higher MT burdens. Western diet challenge led to elevations in glycemic and hepatic biochemistry values only in old monkeys, and immunoglobulin therapy was not effective in reducing MT markers or improving metabolic health. We interpret these findings to suggest that ageing may lead to lower control over colonization at the mucosal surface, and reduced clearance of pathogens resulting in MT and inflammation. Leaky gut in ageing, which is not readily rescued by innate immune support with immunoglobulin, primes the liver for negative consequences of high fat, high sugar diets.

Immunoglobulin A

Immunosenescence

10.1038/s41598-018-29473-9

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Citations (48)

Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus)

Frontiers in Veterinary Science (2022)

Gayathriy Balamayooran Hannah Atkins Rachel N. Andrews Kristofer T. Michalson A. Robert Hutchison

is a Gram-negative bacterium that typical results in enterocolitis in humans and poses significant worldwide risks to public health. An outbreak of yersiniosis in the Vervet/African green monkey colony at the WFSM during the winter of 2015-2016 accounted for widespread systemic infection with high morbidity and mortality. Most of the cases had extensive necrosis with suppuration and large colonies of bacilli in the large bowel and associated lymph nodes; however, the small intestine, stomach, and other organs were also regularly affected. Positive cultures of

Yersiniosis

Yersinia enterocolitica

Enterocolitis

Vervet monkey

Yersinia Infections

Immunosuppression

10.3389/fvets.2022.922961

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