Ryszard Gołda

Kazimierz Wielki University in Bydgoszcz

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Grzegorz Przybylski

Nicolaus Copernicus University

Jerzy Pyskir

Collegium Medicum in Bydgoszcz

Magdalena Pasińska

Nicolaus Copernicus University

Wojciech Jóźwicki

Nicolaus Copernicus University

Aleksandra Gadzińska

Nicolaus Copernicus University

Marta Pilaczyńska-Cemel

Nicolaus Copernicus University

W. Krumrych

Kazimierz Wielki University in Bydgoszcz

Anita Dąbrowska

University of Gdańsk

Małgorzata Pyskir

Collegium Medicum in Bydgoszcz

Małgorzata Bannach

Nicolaus Copernicus University

Cooperative Institutions

Nicolaus Copernicus University

Collegium Medicum in Bydgoszcz

University of Bydgoszcz

Pediatric Nephrology of Alabama

Charles University

University Medical Center

Medical University of Warsaw

Jagiellonian University

University of Zagreb

Renal Research Institute

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Decreased Hypoxia-Inducible Factor-1α in Gastrocnemius Muscle in Rats with Chronic Kidney Disease

Kidney & Blood Pressure Research (2012)

Mariusz Flisiński Andrzej Brymora I Bartłomiejczyk Ewa Wiśniewska Ryszard Gołda

Background/Aims: Hypoxia-inducible factor (HIF)-1α is responsible for increased expression of genes engaged in angiogenesis. Our previous study indicated capillary rarefaction and atrophy of glycolytic fibers, mainly in locomotor muscles of uremic animals. Perhaps these changes are secondary to disturbances of HIF-1α in skeletal muscles. Methods: Expression of HIF-1α at mRNA and protein levels, as well as mRNA of vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS), in gastrocnemius muscle (MG) and longissimus thoracic muscle (ML) were measured by RT-PCR and Western blot. Rats were randomized to subtotal nephrectomy (CKD5/6), uninephrectomy (CKD1/2) or sham operation (controls). Results: For CKD5/6 versus controls, mRNA levels for HIF-1α, VEGF-A, VEGFR-1 and VEGFR-2 were significantly reduced only in MG, while eNOS was significantly decreased and iNOS was significantly increased only in ML. Western blot analysis indicated significantly increased HIF-1α protein levels in MG and ML from CKD1/2 animals versus controls, whereas in the CKD5/6 group, the level of HIF-1α protein decreased significantly in MG and increased significantly in ML versus controls and CKD1/2. Conclusion: The reduced expression of HIF-1α mRNA and protein in locomotor muscle from CKD5/6 animals may be involved in the pathogenesis of uremic myopathy. Increased expression of iNOS in the postural muscles may act as a protective factor through HIF-1α stabilization.

Endothelial NOS

Hypoxia-Inducible Factors

Hypoxia

Muscle Atrophy

10.1159/000339706

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The presence and structure of circulating immune complexes in patients with prostate tumors.

PubMed (2004)

Ryszard Gołda Zbigniew Wolski Małgorzata Wyszomirska-Gołda K Madaliński Jacek Michałkiewicz

The detection, measurement and characterization of circulating immune complexes (CICs) in tumor patients has shown both good and poor correlation with progression of the disease. The origin of the antigens making up the immune complexes in the sera of the cancer patients examined is unknown. They are perhaps antigens specific to the cancer's progress.The levels and molecular weights of circulating immune complexes were estimated in the sera of 48 patients with adenocarcinoma (grades G-1, G-2, and G-3) and 21 patients with benign prostate hyperplasia (BPH) by means of the polyethylene glycol (PEG) precipitation test.The results were compared with those of a group of 45 healthy blood donors. Elevated levels of CICs were observed in 66.7% of the patients with adenocarcinoma and in 38% of those with BPH. No seropositivity for CICs was observed in the control group. Increased seropositivity for CICs was observed in patients with the highness grade of adenocarcinoma: the proportion of seropositive patients in the group of patients with the G-1 phase of disease was 50%, with G-2 75%, and with G-3 71.3%. The molecular weights of the CIC proteins were determined by SDS/PAGE. The serum CICs of both BPH and prostate cancer patients consisted of proteins absent in the CICs of the sera of healthy persons.Determination and analysis of atypical proteins in CICs resulting from carcinogenesis may by useful in improving the diagnosis.

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[Passive smoking at teenager's home suffering from asthma bronchiale and control at the disease with Asthma Control Test].

Przegląd Lekarski (2007)

Grzegorz Przybylski Jerzy Pyskir Magdalena Pasińska Piotr Kopiñski Ryszard Gołda

Allergies of the respiratory system are very often at children. Passive smoking may predispose to allergies. The last news shows that smoking at home increases incidence of asthma. It's concerned passive smokers, especially children. Analysis of controlling asthma, exacerbations was made with ACT test. The larger amount of points in ACT test was obtain the better control of asthma was ascertain. Parents were smokers. In this research 164 children and teenagers between 12 and 18 years old from Swiecie and Bydgoszcz, patients Allergologic Outpatients Clinic in 2005-2006, took part. Asthma Control Test was made after the treatment was started. This results show that there is a strong dependence between smoking at home and controlling asthma bronchiale. The correct score--25 points (means that asthma was controlled properly) was at 75% of patients with no smoking at home. At smoker's home every second child has controlled the disease properly. In families where parents smoke a lot every fifth child has no control of the disease. In families, where parents didn't smoke it was only 3%. This analysis shows that there is a strong dependence between frequency of smoking and amounts of points in ACT test. In families where parents smoke rarely children received maximum score in ACT test than in families where patients smoke a lot. There is also dependence between the age of the members of the household and smoking. It is terrifying that there are far more smoking parents at the age of 35 and younger. In this study the ACT was recognized as useful test to control asthma. If smoking parents undergo antinicotine therapy treatment of asthma will be improved.

Passive smoking

Tobacco smoke

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[Anti-nicotine education applied in relation of parents of the diseased children on chronic allergic diseases of respiratory system].

PubMed (2006)

Grzegorz Przybylski Ryszard Gołda Jerzy Pyskir Magdalena Pasińska Grzegorz Ludwikowski

The allergies of respiratory system are at children the frequent illnesses. Among favorable them factors, risk on passive smoking tobacco can be also. Passive smoking is defined as risk non-smoking on tobacco smoke in environment. Recent reports represent that smoking in home environment tobacco increase on passive smokers' asthma morbidity, especially children in school age. It in it was report the necessity of leadership of anti-nicotine education was underlined in the face of smoking parents. It bets that she should motivate she better parents to cessation smoking, using authority of doctor and love parental. Acting we decided with these principles to analyze effectiveness two year anti-nicotine education which be applied in the face of all treated smoking parents of children with reason of chronic allergic diseases of respiratory system in out-patients. The study comprised parents of 146 children at the Allergy out-Patients clinic, who were diagnosed and cured in years 2003-2005. Generally were 292 persons. The children be treated with reason of bronchial asthma and allergic rhinitis. It the data on subject of smoking of tobacco were collected was on basis of interview got from parents during visits at information bureau on beginning the treatment the children, in his track as well as after two years of education. The anti-nicotine education was applied by whole period of observation during routine medical visits. In moment beginning of treatment in studied group the parents' and education children (n = 292) it 79 the parents' couple did not smoke. Smoking parents among remaining 67 steams were. From among them parents 13 children smoked both, only father in 36 cases smoked and mother in remaining 18 parents' couple smoked. 80 parents smoked with generally. 63 persons after two years of anti-nicotine education the nonsmoking committed one from group smoking. 22 persons among them were from among 24 fathers and 17 mothers' peer in which smoked both parents. Remaining smoking and non-smoking parents granted that children tried to restrain to minimum stay in environment smoking. We on basis of received results to affirm that child's disease has on parents' behaviour essential influence can. It in child was affirmed was all analyzed situations characteristic decrease number with diseased child of smokers' families. Recapitulating anti-nicotine education of the children's parents diseased on chronic allergic diseases of respiratory system is very good restrictive agent their exposition on smoking the tobacco. Contemporaneously in effective way influences on decisions of adults about cessation smoking and the healthy style of life promotes.

Tobacco smoke

Passive smoking

Quit smoking

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Effect of physical exercise on cortisol concentration and neutrophil oxygen metabolism in peripheral blood of horses

Annals of Animal Science (2017)

W. Krumrych Ryszard Gołda Marcin Gołyński H Markiewicz Mateusz Buzała

Abstract The aim of the study was to evaluate the effect of regular physical exercise on cortisol concentration and oxygen-dependent bactericidal activity of neutrophils in peripheral blood in recreational and competitive sport horses (racehorses - Ra, trotters - T, jumping horses - J, driving horses - D). The study was conducted on 55 clinically healthy horses. Blood samples were collected from the external jugular vein three times: before exercise, immediately after exercise, and after 30-min rest. Blood samples were subjected to haematological examination, cortisol concentration was determined by radioimmunoassay (RIA) and neutrophil oxygen metabolism of neutrophils was determined using a chemiluminescence method. The analysis showed that cortisol concentration was significantly higher (P<0.05) post-exercise only in the blood of sport horses. This finding, along with a significant correlation (P<0.00005) with the heart and respiratory rates, suggests that the magnitude of cortisol secretion is associated with the intensity and duration of exercise. The relatively small post-exercise increase in cortisol concentration during different exercises of horses resulted in a transient increase of chemiluminescence activity of neutrophils, mainly in D (P<0.00001) and J horses (P<0.01). In the studied groups analysis of the correlation between cortisol concentration and other parameters showed significant correlation only in the case of the CL total in T (P<0.02) and D horses (P<0.004). It is therefore apparent that in a limited concentration, this hormone may stimulate the activity of these cells, although the effect of other neurohormonal factors cannot be excluded. This result confirms that regular and moderate training loads have a beneficial effect on the immunological status of horses.

Jugular vein

10.1515/aoas-2017-0019

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[Analysis of spreading of smoking habit among pregnant women admitted to the Prenatal Outpatient Clinic in 2005-2006].

Grzegorz Przybylski Magdalena Pasińska Jerzy Pyskir Ryszard Gołda Piotr Kopiński

A harmful influence smoking on health is well known and documented. Smoking during pregnancy has negative influence not only on mothers but also on embryos. In spite of pregnancy is a very good reason to stop smoking only every third pregnant stop smoking during pregnancy. Nicotine, carbon monoxide and cyanide, components of smoke, are very toxic. They have negative influence on immunological mechanisms, and may cause some abnormalities. The aim of this article was to analyse smoking among pregnant, patients of Prenatal Outpatient Clinic where risk of abnormalities and defects during pregnancy is very high. 1088 pregnant, admitted to the prenatal clinic during 2005-2006, was analysed. 288 women were smokers, which made 26% of all patients. There was 23.2% high educated and 43.3% with basic education. Despite of the fact that smoking has negative influence on embryos, pregnant still are smokers. That's why antinicotine therapy should be used during pregnancy.

Outpatient clinic

Prenatal Care

Nicotine replacement therapy

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Migracja polska a choroby układu oddechowego, głównie gruźlica

Grzegorz Przybylski Małgorzata Pyskir Jerzy Pyskir Małgorzata Bannach Ryszard Pujszo

Migration has probably become one of the most important determinants of global health and social development. Poland has been an emigration country for few centuries now. Emigration from Poland used to be predominantly of long-term or permanent character. In the last 20 years it has gained characteristics of a shuttle or circular migration. Historically, human migration has had a major impact on the spread of tuberculosis (TB). According to a recent estimate, more than 150 million people are long-term residents of a country other than their country of birth. This paper aims to give an influence of the migration mainly for work on the respiratory diseases mainly tuberculosis as health problem in Poland. Wholesome problems are happened at recurring for abroad, particularly important in the range of the lung diseases often. Work and the magnitude of duties the growth of these diseases causes, already seen after the return to the country particularly. One can not skip this problem in the aspect of tuberculosis.

Emigration

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Analysis of the environmental risk factors in patients with bronchial asthma, allergic to molds in second year observation

Grzegorz Przybylski Aleksandra Gadzińska Ryszard Gołda Anita Dąbrowska

Mold is a common yet significant allergen. Approximately 5% of people with allergies are subjected to allergic reactions of the respiratory tract which may be caused by mold. It seems that although mold frequently occurs in the outdoor environment, it often happens that indoor exposure must be taken into account in diagnostic procedure. To decrease the risk of mold allergy development or aggravation, indoor mold growth in patient9s closest environment should be prevented. In case of mold colonization at home, school or office, humidity source, which supports its growth, should be found so as to identify it and remove as quickly as possible. From January 2009 to December 2010, 421 subjects were recruited from among outpatients visiting the Allergy Outpatients, Poland. Among them, in 166 patients positive mold allergy tests were obtained. These were patients with symptoms of bronchial asthma. All examined patients were subjected to interview concerning environmental exposure to mold allergens. For this purpose a questionnaire was used concerning demographic factors, living conditions, determination of the age of the building, presence of moisture in the place of living, and active or passive tobacco smoking environment. It seems that exposure to environmental factors such as damp flat, old housing plus tobacco smoking, especially in flats of large concentration, may all be favourable to the occurrence of environmental mold allergy and be the cause of the rise of allergy symptoms as well as invoking exacerbations.

Passive smoking

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Analiza poziomu wybranych parametrów stanu zapalnego, krążących kompleksów immunologicznych oraz związanych z nimi wskaźników (neutrofi l/limfocyt, płytki/limfocyt, CRP/KKI) w raku płuc

Marta Pilaczyńska-Cemel Ryszard Gołda Anita Dąbrowska Grzegorz Przybylski

10.34697/2451-0858-pis-2019-4-001

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Mastitis u bydła mięsnego

H Markiewicz W. Krumrych Ryszard Gołda F. Markiewicz

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